Navigation Links
Vaccinex, Inc. Initiates Clinical Trial of Novel Therapeutic Antibody in Cancer Patients With Advanced Solid Tumors
Date:1/4/2011

ROCHESTER, N.Y., Jan. 4, 2011 /PRNewswire/ -- Vaccinex, Inc. announced today that it has received clearance from FDA and will initiate a Phase 1 clinical trial to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of therapeutic antibody candidate VX15/2503 in cancer patients with advanced solid tumors.

(Logo: http://photos.prnewswire.com/prnh/20101101/NY92716LOGO)

VX15/2503 is a novel humanized antibody that blocks the activity of semaphorin 4D (SEMA4D).  It is the first of two of the Company's therapeutic antibodies expected to begin clinical trials this year. "Advancing VX15 into the clinical stage of development is an exciting achievement for Vaccinex, and a testament to the experience and outstanding capabilities of our research and development teams," said Ray Watkins, Senior Vice President and Chief Operating Officer of the company.

"SEMA4D is an exciting therapeutic target with remarkable biological properties relevant to several disease processes," said Dr. Maurice Zauderer, President and Chief Executive Officer of Vaccinex.  As reflected in its name, semaphorin, the molecule guides the activation and movement of different cell types in different ways.  For example, SEMA4D promotes migration of tumor cells that metastasize to new locations as well as the outgrowth of cells that form new blood vessels required to provide nutrients and energy to tumors.  It is anticipated that, by blocking this signal, the anti-SEMA4D antibody will both inhibit the growth of primary tumors and limit metastases to new sites.  "This is important," Dr. Zauderer said, "because if tumors did not metastasize, then surgeons could cure cancer."  In other tissues and disease processes, for example damage to neurons in demyelinating diseases such as multiple sclerosis (MS)
'/>"/>

SOURCE Vaccinex, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2

Related biology technology :

1. Vaccinex, Inc. Awarded Three Qualifying Therapeutic Discovery Project (QTDP) Grants Under the Patient Protection and Affordable Care Act of 2010 (PPACA)
2. Tolerx Initiates Phase 1 Clinical Trial of TRX518, a First-in-Class anti-GITR Antibody for the Treatment of Cancer
3. Pfizer Stops Clinical Trials of Thelin® and Initiates Voluntary Product Withdrawal in the Interest of Patient Safety
4. GeNO LLC Initiates Phase 2 Trial For Nitric Oxide Delivery System
5. SPECTRAL INITIATES U.S. PIVOTAL TRIAL OF TORAYMYXIN™ IN SEPTIC SHOCK
6. Circassia Initiates Phase II Trials of Novel Grass and Ragweed Allergy Therapies and Advances Phase III Plans for cat Allergy T-Cell Vaccine
7. Cylene Initiates Phase I Trial in Multiple Myeloma With CX-4945 Inhibitor of CK2 and Closes Accompanying Financing
8. Xenon Pharmaceuticals Initiates a Phase 2 Clinical Trial in Post Herpetic Neuralgia (PHN) for Topical XEN402.
9. Pieris Initiates Phase I Clinical Trial for Lead Anticalin Compound
10. Onyx Pharmaceuticals Initiates Phase 1 Study of Oral Proteasome Inhibitor in Advanced Solid Tumors
11. NewLink Initiates Pivotal Phase 3 Clinical Trial of HyperAcute(R)-Pancreas Immunotherapy for Resected Pancreatic Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... -- Research and Markets  has announced the addition of the ... report to their offering. This report analyzes ... Thousands by the following Product Segments: Media, Sera, and Reagents. ... Canada , Japan , ... Latin America . Annual estimates and forecasts are provided for ...
(Date:8/19/2014)... Cellgen Diagnostics today launched ... a corporate lab for its genetic-based medical testing ... a critical component in the move from today’s ... of personalized medicine – a more predictive, preventive, ... contributions will support Cellgen’s intent to develop the ...
(Date:8/19/2014)... 19, 2014 Robin Williams’ passing is ... take on an individual. Symptoms range from slowness ... problems swallowing and severe depression. Parkinson’s disease progressively ... of dopamine producing neurons of the brain. As ... that slowly and progressively gets worse, they look for ...
(Date:8/19/2014)... 19, 2014 Research and ... the "Spectroscopy Equipment and Accessories - ... their offering. This report ... and Accessories in US$ Thousands by the ... Raman Spectrometers, NMR-EPR Spectrometers, Near Infrared (NIR) ...
Breaking Biology Technology:Global Cell and Tissue Culture Supplies - Strategic Business Report 2014 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 3As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 2As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 3Global Spectroscopy Equipment and Accessories - Strategic Business Report 2014 2
... trails national averages in venture capital availability, but the ... detailed in a new report, NorthStar Guide to ... Inc. The report is subtitled, A sourcebook to growth ... Technology Network received an advance copy of the 60-page ...
... An Inquiry Into the Nature and Causes of The Wealth ... was the 18th century equivalent of todays (sanitized) bumper sticker: ... annual revenue of the society as great as he can, ... promote the public interest, nor knows how much he is ...
... joined Green Bays Nsight Telservices (www.nsighttel.com) in 2001 as ... action-packed stint as Chief Technical Officer (CTO) of Chicago ... Local Nsight, NET Cable, and NetNet and heads up ... Services (LMDS) deployment. , , WTN: How did ...
Cached Biology Technology:Growing Venture Capital in Wisconsin 2Growing Venture Capital in Wisconsin 3Wisconsin Economic Summits have given a hand to states progress 2Wisconsin Economic Summits have given a hand to states progress 3Interview: WTN Gets Real with Appletons Brad Hansen - Dot-Com Experience helps Executive to Spot Trends 2Interview: WTN Gets Real with Appletons Brad Hansen - Dot-Com Experience helps Executive to Spot Trends 3
(Date:8/19/2014)... . Taking ... activity in children,Today the Canadian Society of Exercise Physiology ... activity and published their position and recommendations in the ... APNM ). This position stand provides an important ... physical activity for children and suggests both practical guidelines ...
(Date:8/19/2014)... 9- and 10-year-olds finds that those who are more ... in the brain than their peers who are less ... carry nerve signals from one brain region to another. ... more efficient nerve activity. , The team reports ... Neuroscience. , "Previous studies suggest that children with ...
(Date:8/18/2014)... Fish species native to a major Arizona watershed ... by 2050 as surface water flow is reduced by ... Most of these fish species, found in the Verde ... relies on easy access to various resources throughout the ... speckled dace (Rhinichthys osculus), roundtail chub (Gila robusta) and ...
Breaking Biology News(10 mins):Taking a stand: Balancing the BENEFITS and RISKS of physical activity in children 2Taking a stand: Balancing the BENEFITS and RISKS of physical activity in children 3Physically fit kids have beefier brain white matter than their less-fit peers 2Physically fit kids have beefier brain white matter than their less-fit peers 3Climate change will threaten fish by drying out Southwest US streams, study predicts 2Climate change will threaten fish by drying out Southwest US streams, study predicts 3
... at the Institute of Food Research have detected subtle changes ... of tumours. With support from the Food Standards ... are investigating whether diet could control these changes and delay ... changes in 18 genes that play a role in the ...
... heavy metal contaminant levels in dolphins from Port Phillip ... levels may be a contributing factor to dolphin deaths. ... have confirmed levels of mercury found in the dolphins ... and mental effects and were higher than mercury levels ...
... breath-freshening strips, a Temple University researcher has developed ... Greg Smutzer, director of the Laboratory of ... College of Science and Technology ( http://www.temple.edu/biology ), ... but these edible strips contain one of the ...
Cached Biology News:'Addicted' cells provide early cancer diagnosis 2Mercury contamination found in stranded Victorian dolphins 2Taking a cue from breath fresheners, researcher develops new method for taste testing 2Taking a cue from breath fresheners, researcher develops new method for taste testing 3
... TriEx Sf9 Cells and TriEx Insect Cell ... pTriEx baculovirus constructs. This cell/medium combination has ... growth and high protein expression levels observed ... vectors. Please note that our Ready-Plaque Sf9 ...
...
...
...
Biology Products: