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VAP(R) Cholesterol Test Helps Researchers Identify Treatment Effects of Combination Therapy
Date:11/10/2008

s with mixed hyperlipidemia were randomized to one of four treatment groups: placebo; ezetimibe/simvastatin (10/20 mg/d); fenofibrate (160 mg/d); or ezetimibe/simvastatin (10/20 mg/d) + fenofibrate (160 mg/d) for 12 weeks. The primary efficacy endpoint of the trial was percent change in LDL-C from baseline to study endpoint after treatment with ezetimibe/simvastatin + fenofibrate versus fenofibrate alone.

Detailed evaluation of the effects of ezetimibe/simvastatin and fenofibrate both as monotherapy and in coadministration was achieved by examining their effects on individual lipoprotein subclasses. Cholesterol associated with very low density lipoprotein (VLDL), intermediate density lipoprotein (IDL), LDL and HDL subfractions was quantified using the Vertical Auto Profile method. LDL particle size was determined using segmented gradient gel electrophoresis (S3GGE(TM) Berkeley Heart Lab).

A key feature of the comprehensive VAP Test is the identification of the major lipid components of residual risk leading to proper individualized therapy. The VAP Test provides researchers and medical professionals with direct measurement of LDL, HDL and all relevant subclasses, and includes non-HDL, a highly accurate determination of apoB, and emerging risk factors such as Lp(a), remnants and small dense LDL.

"We're pleased that the VAP Test was essential in helping investigators identify an optimal combination of therapies for the treatment of mixed hyperlipidemia," said James Ehrlich, M.D., Atherotech's chief medical officer. "Examining in detail the effect of these therapies on lipoprotein subclasses should lead to improved treatment of at-risk individuals exhibiting elevated LDL, triglycerides and non-high density lipoprotein (HDL) cholesterol plus low HDL."

Researchers reported that ezetimibe/simvastatin and fenofibrate, both as separate therapy and in coadministration, produced beneficial changes in the distribution of lipoprotein subclasses withi
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SOURCE Atherotech, Inc.
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