Navigation Links
Use it or lose it? Researchers investigate the dispensability of our DNA
Date:10/3/2008

October 2, 2008 Our genome contains many genes encoding proteins that are similar to those of other organisms, suggesting evolutionary relationships; however, protein-coding genes account for only a small fraction the genome, and there are many other DNA sequences that are conserved across species. What are these sequences doing, and do we really need them at all? In a study published online today in Genome Research (www.genome.org), researchers have delved into this mystery and found that evolution has actively kept them in our genome.

Before the human genome was sequenced, researchers estimated the genome might contain upwards of 140,000 protein-coding genes, but surprisingly, sequencing revealed only about 20,000, accounting for less than 2% of the entire genome. Previously, Dr. Gill Bejerano of Stanford University found that lurking within the other 98% of the genome are stretches of sequences, known as ultraconserved elements, which are identical between humans and animals such as rodents and chickens, even though hundreds of millions of years of independent evolution separates them.

Other evidence has suggested that ultraconserved sequences can harbor critical functions, such as regulation of the activity of certain genes. Yet research in this field has produced laboratory results that are seemingly in disagreement: some ultraconserved elements can be deleted from the mouse genome and produce no observable effect on mice. Bejerano cautions that laboratory experiments such as these may not be able to detect slow evolutionary forces at work. "With this in mind, we set out to examine the genomic data, much as someone would examine archaeological data, in search of similar deletion events that have happened naturally, and more importantly, were retained in the wild."

"An analogy I like to entertain is that of plate tectonics: a fraction of the phenomena may be strong enough to be dir
'/>"/>

Contact: Peggy Calicchia
calicchi@cshl.edu
516-422-4012
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Researchers improve ability to write and store information on electronic devices
2. Long-awaited international ethical guidelines for biobank researchers
3. CU researchers shed light on light-emitting nanodevice
4. Stevens researchers provide new information about mass spectrometry
5. Researchers measure carbon nanotube interaction
6. Researchers underscore limitations of genetic ancestry tests
7. ASU researchers improve memory devices using nanotech
8. UD researchers race ahead with latest spintronics achievement
9. Researchers outline structure of largest nonvirus particle ever crystallized
10. Ames Laboratory researchers solve fuel-cell membrane structure conundrum
11. Researchers use magnetism to target cells to animal arteries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... (PRWEB) October 22, 2014 According ... Market by Service Type (Consulting, Integration, Deployment & ... by Deployment Model (Public, Private, Others (Hybrid & ... MarketsandMarkets, defines and segments the Cloud Professional Services ... and forecasting of revenues. It also identifies the ...
(Date:10/22/2014)... and HONG KONG , Oct. 22, ... therapeutics enterprise, announced today that rare disease expert ... vice president, research. Dr. McKew brings more than two ... positions at the National Institutes of Health, Wyeth Research ... Wyeth). Dr. McKew will lead aTyr,s efforts to expand and ...
(Date:10/20/2014)... , Oct. 20, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ... million which brings Q3 orders to $5.8 million and provides a ... projects in North America and one in ... to bid new projects at record levels," said Peter Bruijns ... higher at the end of Q3 than they have been for ...
(Date:10/20/2014)... Earle Martin , Chief Executive ... Ellen Teplitzky, an experienced attorney specializing in business ... has joined the firm as Director of Legal ... NDA Partners provides legal services, including research, ... top law firms and their clients in cases ...
Breaking Biology Technology:Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 4Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 5aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2
... (NYSE: DGX ), the world,s leading provider ... for the fourth quarter ended December 31, 2011, adjusted ... per diluted share, compared to $179 million, or $1.03 ... of 2011, reported income from continuing operations was $190 ...
... Lieber, the Mark Hyman Jr. Professor of Chemistry, ... A pioneer in the synthesis of a wide ... unique physical properties of those materials, and the ... Lieber has demonstrated the use of nanoscale materials ...
...  A recent Van Andel Research Institute (VARI) study published in ... function of an essential plant hormone could profoundly change our ... to the development of new drugs for a variety of ... by the same team of investigators at VARI that was ...
Cached Biology Technology:Quest Diagnostics Reports Fourth Quarter 2011 Financial Results; Provides Guidance for 2012 2Quest Diagnostics Reports Fourth Quarter 2011 Financial Results; Provides Guidance for 2012 3Quest Diagnostics Reports Fourth Quarter 2011 Financial Results; Provides Guidance for 2012 4Quest Diagnostics Reports Fourth Quarter 2011 Financial Results; Provides Guidance for 2012 5Quest Diagnostics Reports Fourth Quarter 2011 Financial Results; Provides Guidance for 2012 6Quest Diagnostics Reports Fourth Quarter 2011 Financial Results; Provides Guidance for 2012 7Quest Diagnostics Reports Fourth Quarter 2011 Financial Results; Provides Guidance for 2012 8Quest Diagnostics Reports Fourth Quarter 2011 Financial Results; Provides Guidance for 2012 9Quest Diagnostics Reports Fourth Quarter 2011 Financial Results; Provides Guidance for 2012 10Quest Diagnostics Reports Fourth Quarter 2011 Financial Results; Provides Guidance for 2012 11Quest Diagnostics Reports Fourth Quarter 2011 Financial Results; Provides Guidance for 2012 12Quest Diagnostics Reports Fourth Quarter 2011 Financial Results; Provides Guidance for 2012 13Quest Diagnostics Reports Fourth Quarter 2011 Financial Results; Provides Guidance for 2012 14Quest Diagnostics Reports Fourth Quarter 2011 Financial Results; Provides Guidance for 2012 15Quest Diagnostics Reports Fourth Quarter 2011 Financial Results; Provides Guidance for 2012 16Quest Diagnostics Reports Fourth Quarter 2011 Financial Results; Provides Guidance for 2012 17Quest Diagnostics Reports Fourth Quarter 2011 Financial Results; Provides Guidance for 2012 18Quest Diagnostics Reports Fourth Quarter 2011 Financial Results; Provides Guidance for 2012 19Quest Diagnostics Reports Fourth Quarter 2011 Financial Results; Provides Guidance for 2012 20Quest Diagnostics Reports Fourth Quarter 2011 Financial Results; Provides Guidance for 2012 21Quest Diagnostics Reports Fourth Quarter 2011 Financial Results; Provides Guidance for 2012 22Quest Diagnostics Reports Fourth Quarter 2011 Financial Results; Provides Guidance for 2012 23Quest Diagnostics Reports Fourth Quarter 2011 Financial Results; Provides Guidance for 2012 24Quest Diagnostics Reports Fourth Quarter 2011 Financial Results; Provides Guidance for 2012 25Quest Diagnostics Reports Fourth Quarter 2011 Financial Results; Provides Guidance for 2012 26Quest Diagnostics Reports Fourth Quarter 2011 Financial Results; Provides Guidance for 2012 27Quest Diagnostics Reports Fourth Quarter 2011 Financial Results; Provides Guidance for 2012 28Van Andel Research Institute Study Provides New Details of Fundamental Cellular Process 2
(Date:10/16/2014)... constantly wages war on the human body. Battles ... stalemate. In pancreatic cancer, this stalemate—known as tumor ... aggressively malignant, a phenomena that is poorly understood. ... the laboratory of Salvatore Torquato, a Professor of ... conditions surrounding tumor dormancy and the switch to ...
(Date:10/16/2014)... tract infections and worldwide claims the lives of ... Ghent University have succeeded in developing a promising ... , Xavier Saelens (VIB/UGent): "We discovered a ... the development of a novel approach to vaccination ... numerous small children and elderly people." , ...
(Date:10/15/2014)... is a non-traditional biophysics textbook and it describes how ... journey of discovery into biological systems and provides an ... It is about how our genes make proteins that ... of cells in an organism. It quantifies the principles ... can be found on both large and small scales. ...
Breaking Biology News(10 mins):Modeling tumor dormancy 2New perspectives for development of an RSV vaccine 2New book about life as seen from physics 2
... help scientists "build" new biological systems, Princeton University scientists ... enable the growth of living cells. The team ... nature, and the scientists showed that they can produce ... as proteins produced by nature,s own toolkit. ...
... ATHENS, Ohio (Jan. 6, 2011) Ohio University ... the bioengineering profession,s highest honor, the Fritz J. and ... Hood of Seattle, Washington, for his discoveries related to ... president and co-founder of the Institute for Systems Biology, ...
... at the University of Connecticut Health Center have identified a ... a predictor of heart attack. Their research, led by ... Cardiology Center, is published in the Jan. 11 issue of ... It found heart attack patients had elevated levels of the ...
Cached Biology News:Princeton scientists construct synthetic proteins that sustain life 2Princeton scientists construct synthetic proteins that sustain life 3DNA sequencing pioneer receives 2011 Russ Prize 2DNA sequencing pioneer receives 2011 Russ Prize 3
Biotin d anti-mouse Tim-1...
Mouse monoclonal [1-N-14] to Adenovirus Type 7 hexon C11 Immunogen: Purified Adenovirus type 7 Specificity: This antibody is specific for Adenovirus type 7 hexon C11....
Request Info...
... is the main excitatory neurotransmitter in the ... considered to act only on the ligand-gated ... that are involved in the fast excitatory ... to regulate enzymes producing second messengers via ...
Biology Products: