Navigation Links
Use it or lose it? Researchers investigate the dispensability of our DNA
Date:10/3/2008

October 2, 2008 Our genome contains many genes encoding proteins that are similar to those of other organisms, suggesting evolutionary relationships; however, protein-coding genes account for only a small fraction the genome, and there are many other DNA sequences that are conserved across species. What are these sequences doing, and do we really need them at all? In a study published online today in Genome Research (www.genome.org), researchers have delved into this mystery and found that evolution has actively kept them in our genome.

Before the human genome was sequenced, researchers estimated the genome might contain upwards of 140,000 protein-coding genes, but surprisingly, sequencing revealed only about 20,000, accounting for less than 2% of the entire genome. Previously, Dr. Gill Bejerano of Stanford University found that lurking within the other 98% of the genome are stretches of sequences, known as ultraconserved elements, which are identical between humans and animals such as rodents and chickens, even though hundreds of millions of years of independent evolution separates them.

Other evidence has suggested that ultraconserved sequences can harbor critical functions, such as regulation of the activity of certain genes. Yet research in this field has produced laboratory results that are seemingly in disagreement: some ultraconserved elements can be deleted from the mouse genome and produce no observable effect on mice. Bejerano cautions that laboratory experiments such as these may not be able to detect slow evolutionary forces at work. "With this in mind, we set out to examine the genomic data, much as someone would examine archaeological data, in search of similar deletion events that have happened naturally, and more importantly, were retained in the wild."

"An analogy I like to entertain is that of plate tectonics: a fraction of the phenomena may be strong enough to be directly measured by our instruments, but to appreciate its full magnitude we must dig into the geological record," said Bejerano. "This digging into the genomic record is what our current work was all about."

Bejerano and graduate student Cory McLean studied the genomes of six mammals, investigating ultraconserved elements that are shared between primates and closely related mammals, were present in the ancestor of modern rodents, but have been lost in the rodent lineage more recently. The researchers found that the genomic evidence supports an important biological role for ultraconserved elements, as well as thousands of other non-coding elements that are resistant to deletion. "The functional importance of ultraconserved elements is reinforced by the observation that the elements are rarely lost in any species," said McLean. "In fact, they are over 300-fold less likely to be lost than genomic loci which evolve neutrally in our genome."

Bejerano explained that while loss of some elements may have a significant impact on the fitness of a species and the loss of other elements might be harder to detect in the laboratory, nearly all changes to these regions are picked up by evolution and swept out of the population.

"Perhaps our most striking observation is one of sheer magnitude," Bejerano said. "Our work highlights how essential these dozens of thousands of regions are to the natural evolution of a species even as their actual functions remain, at large, a mystery."


'/>"/>

Contact: Peggy Calicchia
calicchi@cshl.edu
516-422-4012
Cold Spring Harbor Laboratory
Source:Eurekalert

Related biology technology :

1. Researchers improve ability to write and store information on electronic devices
2. Long-awaited international ethical guidelines for biobank researchers
3. CU researchers shed light on light-emitting nanodevice
4. Stevens researchers provide new information about mass spectrometry
5. Researchers measure carbon nanotube interaction
6. Researchers underscore limitations of genetic ancestry tests
7. ASU researchers improve memory devices using nanotech
8. UD researchers race ahead with latest spintronics achievement
9. Researchers outline structure of largest nonvirus particle ever crystallized
10. Ames Laboratory researchers solve fuel-cell membrane structure conundrum
11. Researchers use magnetism to target cells to animal arteries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2017)... (PRWEB) , ... June 20, 2017 , ... ... to immediately determine the adulterants which pose the most likely threat to their ... 28 of this year. , IFT's annual food expo attracts over 20,000 ...
(Date:6/20/2017)... (PRWEB) , ... June 20, 2017 , ... ... for discovery of antibody therapeutics from millions-diverse immune repertoires, announces launch of its ... San Diego, California. Dave Johnson, PhD, CEO of GigaGen, will present on Surge ...
(Date:6/19/2017)... ... June 19, 2017 , ... A colony of healthy honey bees is ... by delivering pollen and nectar containing nutrients necessary for growth and survival. Better nutrition ... Many recent indicators point to a decline in honey bee health. Sick and weakened ...
(Date:6/15/2017)... ... June 15, 2017 , ... New resistant soybean and cotton ... managing Palmer amaranth and other broadleaf weeds resistant to glyphosate. But scientists with ... herbicides are known to drift and to cause harm to sensitive, off-target broadleaf ...
Breaking Biology Technology:
(Date:4/11/2017)... , April 11, 2017 NXT-ID, Inc. ... technology company, announces the appointment of independent Directors Mr. ... to its Board of Directors, furthering the company,s corporate governance ... Gino ... we look forward to their guidance and benefiting from their ...
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... anticipated to expand at a CAGR of 25.76% during ... diseases is the primary factor for the growth of ... report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global ... product, technology, application, and geography. The stem cell market ...
(Date:3/30/2017)... HONG KONG , March 30, 2017 ... developed a system for three-dimensional (3D) fingerprint identification by adopting ground ... technology into a new realm of speed and accuracy for use ... applications at an affordable cost. ... ...
Breaking Biology News(10 mins):