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Urologists Debunk Misleading, Grossly Inaccurate Prostate Cancer Biopsy Study
Date:4/13/2012

e based on biopsies of 12 parts of the prostate gland.

Numerous international organizations including the National Comprehensive Cancer Network, the American Urological Association and the Canadian Urologic Association have issued practice guidelines recommending the use of extended (10-12 core) biopsy protocols to improve cancer detection rates. Of note is that these guidelines were based on literature that was published before the study period, all facts that Mitchell completely ignores in her work.

For more than a decade, the peer review literature has been clear:

  • The detection of clinically significant prostate cancer is improved with increased number of cores.
  • Staging and grading of cancer is substantially improved with increased number of cores.
  • The need for repeat prostate biopsy is reduced when more cores are initially taken.
  • Complication rates are not increased with increased number of cores.

The data on this is so overwhelming, even the pathology organization that funded the study was forced to acknowledge the recommendation of the National Comprehensive Cancer Network's guidelines on Prostate Cancer Early Detection, and commercial labs routinely provide 12 or more vials for specimen collection in their prostate biopsy kits.

Mitchell further states, "There is no clinical rationale for placing each core in a separate jar." This again ignores prevailing standards of care; to map the location of prostate cancer requires separating the cores into individual containers. This provides information about laterality of disease, volume of cancer in each location, along with Gleason scoring of each core – all of which are of profound importance to planning both surgical and radiation therapy treatments.

Mitchell hand selected 11 counties out of more than 3,100 in the United States, reviewing only 9,976 biopsies in urology groups with in‐
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SOURCE Large Urology Group Practice Association
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