Navigation Links
Upsher-Smith Presents Favorable Phase I Data For USL261, A Novel Formulation Of Intranasal Midazolam, At 65th Annual Meeting Of The American Academy Of Neurology
Date:3/19/2013

Division Chair, University of Wisconsin, "The data presented at AAN from the development program for USL261 support the safety profile and favorable pharmacokinetics/pharmacodynamics of USL261 in healthy volunteers.  These findings support the further development of USL261 for seizure rescue in patients with intermittent bouts of increased seizure activity, a population for which few treatment options are currently available."

USL261 (Intranasal Midazolam) Data  

USL261 data presented at AAN 2013 examined the pharmacokinetics, pharmacodynamics, safety, and tolerability of USL261 in healthy volunteers.  In this study, increasing USL261 doses corresponded with an apparent linear increase in midazolam exposure, with all doses demonstrating rapid time to maximal plasma concentration (10 – 15 min).  Researchers concluded that USL261 dosed up to 7.5 mg was generally well tolerated and did not result in excessive or prolonged sedation or psychomotor impairment.  Further, when compared with an equivalent dose of injectable midazolam delivered intranasally, USL261 demonstrated improved midazolam bioavailability with similar pharmacodynamic effects and safety/tolerability profiles.  

Abstracts of the poster presentations can be found online at: http://www.aan.com 

  • Safety and Pharmacodynamics of USL261, a Novel Formulation of Midazolam Optimized for Intranasal Administration
    P02.211. Session P02:  Epilepsy:  Novel Therapeutics and Basic Science
  • Pharmacokinetics of USL261, a Novel Formulation of Intranasal Midazolam
    P02.212. Session P02:  Epilepsy:  Novel Therapeutics and Basic Science

About Epilepsy

Epilepsy is a medical condition that causes seizures affecting a variety of cognitive and physical functions.  More than two million
'/>"/>

SOURCE Upsher-Smith Laboratories, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related biology technology :

1. Upsher-Smith Currently Recruiting People With Epilepsy To Evaluate Investigational Rescue Treatment For Seizure Clusters
2. Upsher-Smith Launches B-Nexa® Prescription Prenatal Vitamin With B Vitamins and Ginger for Nausea and Vomiting of Pregnancy
3. Assemblyman Levine Presents Resolution Recognizing Rare Disease Day at Capitol
4. Drogueria Americana, a Honduran Affiliate of GeneCell International, Presents to a Panel of More Than 100 Leading Dentist on Dental Pulp Stem Cells
5. Cellular Biomedicine Group President Presents Keynote Address at New York Stem Cell Summit
6. Bluestar Silicones Presents Soft Silicone Advantages At Medical Design And Manufacturing (MD&M) West Show
7. Oracle’s Value Chain Summit San Francisco: Track Sponsor NexInfo presents more industry specific solutions
8. Fertility Associates of Memphis, World-Renowned Expert in Infertility, Presents Findings to European Conference
9. BCA Represents Independent Blood Centers at Phacilitate Cell & Gene Therapy Forum
10. HealthEconomics.Com Presents Top News Stories in Pharma Reimbursement and Pricing from this Week's Newsletter
11. NKT Therapeutics Presents Data on Potential Antibody Treatment for Sickle Cell Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2015)... , May 27, 2015 Research ... of Jain PharmaBiotech,s new report "Cell Therapy ... offering. This report describes and evaluates ... started to play an important role in the ... replacing the old fashioned bone marrow transplants. Role ...
(Date:5/28/2015)... May 28, 2015 The Academy of Model ... Aviation Day on August 15, 2015. National Model Aviation Day ... and to introduce model flying to the general public. , ... clubs to participate in the celebration by hosting events in ... host National Model Aviation Day events. View our online ...
(Date:5/28/2015)... Calif. , May 28, 2015 ... today announced a study published in Ultrasound ... Panorama single-nucleotide polymorphism (SNP)-based non-invasive prenatal test (NIPT) ... first trimester. A study based ... complete molar pregnancies occur in about 1 in ...
(Date:5/28/2015)... BioNorth Texas (BioNorthTX), an independent, ... life sciences industry in northern region of Texas, ... The Foundry in Dallas on April 27, 2015. ... a broad spectrum of biotech professionals from the ... successes in partnering with key life sciences organizations ...
Breaking Biology Technology:Global Cell Therapy Market 2015-2020 - Technologies, Markets and Companies 2Model flying pilots celebrate the Academy of Model Aeronautics Foundation’s Third Annual National Model Aviation Day 2First Confirmed Detection of a Complete Molar Pregnancy with Cell-Free DNA Test 2First Confirmed Detection of a Complete Molar Pregnancy with Cell-Free DNA Test 3BioNorthTX Holds Inaugural Board of Directors Meeting 2BioNorthTX Holds Inaugural Board of Directors Meeting 3
... This Thursday, the 17th annual SBIR/STTR Conference will be ... at the Crowne Plaza in Madison, 4402 E. Washington. ... Business Innovation Research (SBIR) and Small Business Technology Transfer ... billion federal dollars available to small businesses for technological ...
... Corporation, a growth company of ... its Cequent Transportation Accessories Group ... provider of zinc plating services. ... Wis. and has been a ...
... worldwide leader in e-document delivery ... and VSI-FAX(R) product families, announces ... This new solution allows Lotus ... efficiently, effectively, and economically with ...
Cached Biology Technology:Annual Conference Honors Tech Grant Winners 2
(Date:5/11/2015)... , May 11, 2015  Through a well-rounded UAS ... had a strong showing at AUVSI,s Unmanned 2015 ... representatives of Ohio,s UAS industry met ... abroad from all points along the UAS ecosystem. ... Coalition,s (DDC) Vice President for Aerospace Rich Knoll . ...
(Date:5/6/2015)... , May 6, 2015 LifeBEAM, a developer ... helmet producer, announced today that they will expand their ... world,s first bio-sensing cycling helmet and the first joint ... two new colors in order to give cyclists more ... In addition, LifeBEAM and Lazer announced their plan to ...
(Date:4/21/2015)... April 21, 2015 High ... policies are boosting access control systems market in ... to a recently published report by TechSci Research " ... the access control systems market in Saudi ... by 2020.The access control systems market in the Kingdom ...
Breaking Biology News(10 mins):Ohio Flies High at Unmanned '15, Sets Stage for Ohio UAS Conference 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3
... thought that interactions between plants and pollinating insects hasten ... show that some interactions between plants and pollinators are ... in some instances, reduce it. Findings, published in ... local populations of one of the most distinctive plants ...
... of salmonella caused by infected eggs resulted in thousands ... Now, University of Missouri researchers have created a new ... produce faster and more accurate results than most currently ... contaminated eggs from being shipped to stores. ...
... from the Harvard School of Public Health (HSPH) finds that ... a problem of the rich. The findings suggest that the ... already happened in wealthier countries has not yet happened in ... of the American Journal of Clinical Nutrition and ...
Cached Biology News:The puzzle of biological diversity 2MU scientist develops salmonella test that makes food safer, reduce recalls 2Overweight primarily a problem among wealthier women in low- to middle-income countries 2
... acid analysis standard is a ... salts; molecular weights range from ... is provided for use with ... the organic acid analysis kit ...
... demonstrated that oxidative stress is involved in ... stress is the condition in which an ... exist leading to the damage of a ... stress is through several antioxidant systems4 that ...
... Versatile affinity matrix for the extraction ... proteins or other macromolecules, Applications: ,Reducing ... of the interaction of pure β-adrenergic ... Removing residual SDS in 6 M ...
Values of steady state parameters for enzyme activities are determined....
Biology Products: