Navigation Links
University of Western Ontario researchers investigate stress and breast cancer

It's a common belief that there's a link between chronic stress and an increased risk of cancer. In new research published online by the International Journal of Cancer, scientists at The University of Western Ontario have taken a step toward confirming that belief.

Research led by Dwayne Jackson of the Departments of Medical biophysics and Biomedical Engineering has identified a particular neurotransmitter released in response to stress, that stimulates both cancer cell growth and migration in breast cancer.

Working with Ph.D candidate Philip Medeiros, Jackson looked at a branch of the nervous system called the sympathetic nervous system, and how it "talks" to cells in various organs throughout the body. When the sympathetic nervous system is activated, like it is during stress, it communicates with receptors on cells through the release of neurotransmitters called norepinephrine and neuropeptide Y or NPY. This is a normal response that prepares the body for "fight or flight".

"We have all heard anecdotally that stress causes cancer. Our lab is particularly interested in how chronic stress may cause increases in the release of NPY and whether that may contribute to the progression of breast cancer," explains Jackson, an Assistant Professor at Western's Schulich School of Medicine & Dentistry. "It has been shown that women with a familial history of breast cancer exhibit greater physiological stress responses to normal everyday stressors. Since there is a very dense supply of sympathetic nerves in the female breast, it would be reasonable to suspect that NPY may be released in greater amounts in the breasts of those at risk for breast cancer. Thus, we postulated if cancer cells are present and they respond to NPY, then this neuropeptide and its receptors would form a functional link between stress and breast cancer progression."

"Once we had established that breast cancer cells express the receptors for NPY, then we went through a set of experiments that looked at the functional consequences of activating them. We found NPY greatly accelerates cell growth as well as cell migration and these are two important steps in primary tumour growth, as well as in metastasis," concludes Medeiros.

Contact: Kathy Wallis
519-661-2111 x81136
University of Western Ontario

Related biology technology :

1. SanBio Announces Site Opening of Phase 1/2a Clinical Trial of Novel Cell Therapy in Stable Stroke Patients at University of Pittsburgh Medical Center
2. HUYA Bioscience International Forms Alliance With Zhejiang Chinese Medical University Life Science College
3. Swedish University Hospital Improves Monitoring of Treatment Efficacy in Multiple Sclerosis With Synthetic MRI Innovation
4. University of Houston receives NSF grant for high school teachers program
5. New nanoscale parameter by Aalto University resolves dilemmas on silicon property
6. University of Muenster Bridges 1st Patient to Transplant with SynCardias Total Artificial Heart
7. Elsevier and the National University of Singapore Announce Winners of 24-Hour Hackathon
8. The Human Brain is Sensitive to Light, Breakthrough Findings From Valkee and the University of Oulu
9. CEM President and CEO Delivers Commencement Address at the University of Texas at Austin Chemistry and Biochemistry Department Graduation
10. Computerized system to prevent SIDS developed by Ben-Gurion University students
11. University of Dayton Study Overturns 250-Year-Old Belief About Effects of Age, Repeated Injury on Tissue Regeneration
Post Your Comments:
(Date:12/1/2015)... Dec. 1, 2015  Symic, a clinical-stage biotherapeutics company ... matrix (ECM), today announced that it has secured $25 ... company,s pipeline, including its lead candidates SB-030 and SB-061. ... the participation by all existing major investors, as well ... total capital raised by Symic to over $43 million ...
(Date:12/1/2015)... ... ... Matthew “Tex” VerMilyea, PhD, HCLD, has joined Texas Fertility Center as its ... procedures as well as continue his research efforts into the emerging technologies of embryo ... Zealand to bring home a High Complexity Clinical Laboratory Director named Tex,” says ...
(Date:11/30/2015)... ... , ... Global Stem Cells Group today announced ... Marriott. The Global Stem Cells Group GMP facility is equipped with the most ... researchers and practitioners, experienced in administering stem cell protocols using highly manipulated cells. ...
(Date:11/30/2015)... Partnership includes an MPP ... the u niversity , s Solid Drug Nanoparticle ... cale - up through cost ... , where licensees based anywhere in the world will have the right to ... Africa , where licensees based anywhere in the world will have the ...
Breaking Biology Technology:
(Date:11/12/2015)... CAMBRIDGE, Mass. , Nov. 12, 2015 /PRNewswire/ ... Broad Institute of MIT and Harvard for use ... chemical discovery information management tools. The partnership will ... share both biological and chemical research information internally ... tools will be used for managing the Institute,s ...
(Date:11/9/2015)... 09, 2015 ... the "Global Law Enforcement Biometrics Market ... --> ) has announced the ... Biometrics Market 2015-2019" report to their ... ( ) has announced the addition ...
(Date:10/29/2015)... Calif. , Oct. 29, 2015  The J. ... new report titled, "DNA Synthesis and Biosecurity: Lessons Learned ... the Department of Health and Human Services guidance for ... in 2010. --> ... it also has the potential to pose unique biosecurity ...
Breaking Biology News(10 mins):