Navigation Links
University of Utah chemists use nanopores to detect DNA damage
Date:6/18/2012

SALT LAKE CITY, June 18, 2012 Scientists worldwide are racing to sequence DNA decipher genetic blueprints faster and cheaper than ever by passing strands of the genetic material through molecule-sized pores. Now, University of Utah scientists have adapted this "nanopore" method to find DNA damage that can lead to mutations and disease.

The chemists report the advance in the week of June 18 online edition of the journal Proceedings of the National Academy of Sciences.

"We're using this technique and synthetic organic chemistry to be able to see a damage site as it flies through the nanopore," says Henry White, distinguished professor and chair of chemistry at the University of Utah and senior coauthor of the new study.

Strands of DNA are made of "nucleotide bases" known as A, T, G and C. Some stretches of DNA strands are genes.

The new method looks for places where a base is missing, known as an "abasic site," one of the most frequent forms of damage in the 3-billion-base human genome or genetic blueprint. This kind of DNA damage happens 18,000 times a day in a typical cell as we are exposed to everything from sunlight to car exhaust. Most of the damage is repaired, but sometimes it leads to a gene mutation and ultimately disease.

By combining nanopore damage-detection with other chemical ways of altering DNA, the researchers hope to make this new technique capable of detecting other kinds of DNA damage by converting the damage to a missing base, says the study's other senior coauthor, Cynthia Burrows, a distinguished professor of chemistry at the University of Utah.

She adds: "Damage to the bases of DNA contributes to many age-related diseases, including melanoma; lung, colon and breast cancers; Huntington's disease; and atherosclerosis."

A patent is pending on the new method of doing chemistry on DNA that allows damage sites to be found using nanopore technology.

White a
'/>"/>

Contact: Lee Siegel
lee.siegel@utah.edu
801-581-8993
University of Utah
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology technology :

1. Stevenage Bioscience Catalyst to Welcome Cambridge University Researchers
2. RayBiotech, Inc. and the University of Oslo Enter into Antibody Array Services Collaboration
3. Northeastern University Nanomanufacturing Center Director Ahmed Busnaina to Present Webinar on “The Democratization of Manufacturing”
4. Syracuse University researchers use nanotechnology to harness power of fireflies
5. University of Florida physicists set new record for graphene solar cell efficiency
6. CEM President and CEO Delivers Commencement Address at the 2012 University of Texas at Austin Chemistry and Biochemistry Department Graduation
7. IntelliCell BioSciences Announces Collaborative Agreement with the University of Florida on Stem Cell and Tissue Repair Research
8. Intellect Neurosciences Enters Collaboration Agreement with Leading Alzheimers Research Group at University of California Irvine to Test First in Class Dual Target Vaccine
9. Oxitec Responds to University of Panamas Forum on Transgenic Mosquitoes
10. Valkee and University of Oulu Publish the First Clinical Trial on Bright Light Therapy Channeled via ear Canals in Seasonal Depression
11. EUR 1.0 Million Grant Awarded to Exosome Diagnostics and Ludwig Maximilian University from German Federal Ministry for Education and Research to Develop Biofluid-Derived Exosome Diagnostics
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
University of Utah chemists use nanopores to detect DNA damage
(Date:9/18/2014)... (PRWEB) September 18, 2014 Pipette.com ... include Sartorius/Biohit, Socorex, Capp, and AccuPet brand of ... of 100 uL or less and are a ... forensic applications. , The micropipette promotions were ... and economic alternative products to help customers find ...
(Date:9/17/2014)... SAN FRANCISCO , Sept. 17, 2014 /PRNewswire/ ... patients receiving accelerated partial breast irradiation (APBI) via ... and those with positive lymph nodes could be ... for Radiation Oncology (ASTRO) guidelines place these patients ... an abstract at the 2014 ASTRO meeting, Beaumont ...
(Date:9/17/2014)... SAN DIEGO and PRINCETON, N.J. ... Inc. (NASDAQ: OTCQB:AEMD), the pioneer in developing targeted therapeutic ... conditions, and its diagnostic subsidiary, Exosome Sciences, Inc. (ESI), ... the 2014 Exosomes & SingleCell Analysis Summit. ... of Exosome Sciences will give a presentation entitled: "Exosomes: ...
(Date:9/17/2014)... 17, 2014 JH Technologies ... located in Irvine. JH Technologies, a leader in ... recently announced an expanded partnership with Leica Microsystems into ... and image analysis solutions will be featured at the ... The new showroom facility is located within the JH ...
Breaking Biology Technology:Major Pipette Distributor Pipette.com Announces Promotions on Sartorius/Biohit, Socorex, Capp, and AccuPet Micropipettes 2Major Pipette Distributor Pipette.com Announces Promotions on Sartorius/Biohit, Socorex, Capp, and AccuPet Micropipettes 3Partial Breast Irradiation With Interstitial Brachytherapy Appears Appropriate For Women Previously Considered Unsuitable 2Partial Breast Irradiation With Interstitial Brachytherapy Appears Appropriate For Women Previously Considered Unsuitable 3Partial Breast Irradiation With Interstitial Brachytherapy Appears Appropriate For Women Previously Considered Unsuitable 4Aethlon Medical and Exosome Sciences To Present at the Exosomes & SingleCell Analysis Summit 2Aethlon Medical and Exosome Sciences To Present at the Exosomes & SingleCell Analysis Summit 3JH Technologies displays newest microscope imaging technology at Southern California showroom grand opening 2JH Technologies displays newest microscope imaging technology at Southern California showroom grand opening 3
... , Prepare DNA from blood, cultured cells, or bacteria: ... for 1530 min, then , boil for 8 min. ... , substrate for PCR amplification. , ... Use whole blood samples that are frozen, refrigerated, or collected fresh. , ...
... Genomic DNA Isolation Kit , Catalog #732-6340 , ... Method , Cell ... cerebrospinal fluid, plasma, saliva, serum, , sputum, synovial fluid, urine, whole ... 5 ml cell lysis solution. Pipet up and down several times , ...
... Ph.D. , MJ Research, Inc., South San Francisco, ... Abstract , We present a ... and quantitation of soy genetically modified to be resistant to the herbicide , ... of the genetically modified organism (GMO) specific sequences as ...
Cached Biology Technology:InstaGene Matrix: Prepare DNA Templates for PCR With No Phenol/Chloroform Extractions and No Deproteinization Steps, Rev C 2Genomic DNA Isolation From 1 ml of Body Fluid 2Detection of Genetically Modified Soybean in Processed Foods Using Real-Time Quantitative PCR with SYBR Green I Dye on the DNA Engine Opticon 2 System 2Detection of Genetically Modified Soybean in Processed Foods Using Real-Time Quantitative PCR with SYBR Green I Dye on the DNA Engine Opticon 2 System 3Detection of Genetically Modified Soybean in Processed Foods Using Real-Time Quantitative PCR with SYBR Green I Dye on the DNA Engine Opticon 2 System 4Detection of Genetically Modified Soybean in Processed Foods Using Real-Time Quantitative PCR with SYBR Green I Dye on the DNA Engine Opticon 2 System 5Detection of Genetically Modified Soybean in Processed Foods Using Real-Time Quantitative PCR with SYBR Green I Dye on the DNA Engine Opticon 2 System 6Detection of Genetically Modified Soybean in Processed Foods Using Real-Time Quantitative PCR with SYBR Green I Dye on the DNA Engine Opticon 2 System 7Detection of Genetically Modified Soybean in Processed Foods Using Real-Time Quantitative PCR with SYBR Green I Dye on the DNA Engine Opticon 2 System 8
(Date:9/17/2014)... at UTSouthwestern Medical Center have found that the most ... apoE3, helps repair the lining of blood vessels. Individuals ... benefit of this repair, putting them at higher risk ... identified one mechanism by which apoE3 promotes a healthy ... detrimental," said Dr. Philip Shaul , Professor of ...
(Date:9/17/2014)... decline, grasses have returned to some once-denuded patches of ... those places seems healthy again, but a new study ... coastal protection remains diminished. , "We,ve got ... back," said ecologist Mark Bertness, professor of biology at ... journal Biological Conservation . "The metric of a ...
(Date:9/17/2014)... United Kingdom forms a new crime unit designed to ... last year over horse meat being passed off as ... for detecting meat adulteration. They describe their approach, which ... Journal of Agricultural and Food Chemistry . , ... a major global economic problem. But they also say ...
Breaking Biology News(10 mins):Protein variant may boost cardiovascular risk by hindering blood vessel repair 2Cape Cod saltmarsh recovery looks good, falls short 2Cape Cod saltmarsh recovery looks good, falls short 3
... Like a kindergarten or a busy airport where cold ... places where pollinators such as bees and butterflies can pick ... benign as the sniffles or as debilitating as influenza. ... pollinators are transmitted at flowers," postdoctoral researcher Scott McArt and ...
... are more positive than negative now with regards to the ... way to go." Considerable progress has been made in ... continues to generate smoke from the open mine. Fire ... there are still "weeks of firefighting ahead" according to Craig ...
... New research from Plymouth State University and the ... horseshoe crabs for biomedical purposes causes short-term changes in ... population decline in parts of the east coast. ... blue blood from almost half a million living horseshoe ...
Cached Biology News:As hubs for bees and pollinators, flowers may be crucial in disease transmission 2Biomedical bleeding affects horseshoe crab behavior 2Biomedical bleeding affects horseshoe crab behavior 3
... 2000 instrument can be used as a ... Data Manager Software provides the means to ... the instrument. These data can then be ... such as Microsoft Excel or Lotus 123, ...
... Gasket slide kit (1x 22K gasket/slide) G2534-60003 ... or Gasket slide kit (2x 11K ... slides offered in either 11K or 22K microarray feature ... gaskets are carefully fabricated and batch tested to ensure ...
... is a new product number, ... product number. If showing no ... the old Sigma-Aldrich number (Z71,346-5) ... assistance. ID clarifier: box holds ...
... description: self locking design in ice/water ... new product number, created to easily ... no availability yet, please order under ... contact customer service for assistance. ID ...
Biology Products: