Navigation Links
University of Utah chemists use nanopores to detect DNA damage
Date:6/18/2012

SALT LAKE CITY, June 18, 2012 Scientists worldwide are racing to sequence DNA decipher genetic blueprints faster and cheaper than ever by passing strands of the genetic material through molecule-sized pores. Now, University of Utah scientists have adapted this "nanopore" method to find DNA damage that can lead to mutations and disease.

The chemists report the advance in the week of June 18 online edition of the journal Proceedings of the National Academy of Sciences.

"We're using this technique and synthetic organic chemistry to be able to see a damage site as it flies through the nanopore," says Henry White, distinguished professor and chair of chemistry at the University of Utah and senior coauthor of the new study.

Strands of DNA are made of "nucleotide bases" known as A, T, G and C. Some stretches of DNA strands are genes.

The new method looks for places where a base is missing, known as an "abasic site," one of the most frequent forms of damage in the 3-billion-base human genome or genetic blueprint. This kind of DNA damage happens 18,000 times a day in a typical cell as we are exposed to everything from sunlight to car exhaust. Most of the damage is repaired, but sometimes it leads to a gene mutation and ultimately disease.

By combining nanopore damage-detection with other chemical ways of altering DNA, the researchers hope to make this new technique capable of detecting other kinds of DNA damage by converting the damage to a missing base, says the study's other senior coauthor, Cynthia Burrows, a distinguished professor of chemistry at the University of Utah.

She adds: "Damage to the bases of DNA contributes to many age-related diseases, including melanoma; lung, colon and breast cancers; Huntington's disease; and atherosclerosis."

A patent is pending on the new method of doing chemistry on DNA that allows damage sites to be found using nanopore technology.

White a
'/>"/>

Contact: Lee Siegel
lee.siegel@utah.edu
801-581-8993
University of Utah
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology technology :

1. Stevenage Bioscience Catalyst to Welcome Cambridge University Researchers
2. RayBiotech, Inc. and the University of Oslo Enter into Antibody Array Services Collaboration
3. Northeastern University Nanomanufacturing Center Director Ahmed Busnaina to Present Webinar on “The Democratization of Manufacturing”
4. Syracuse University researchers use nanotechnology to harness power of fireflies
5. University of Florida physicists set new record for graphene solar cell efficiency
6. CEM President and CEO Delivers Commencement Address at the 2012 University of Texas at Austin Chemistry and Biochemistry Department Graduation
7. IntelliCell BioSciences Announces Collaborative Agreement with the University of Florida on Stem Cell and Tissue Repair Research
8. Intellect Neurosciences Enters Collaboration Agreement with Leading Alzheimers Research Group at University of California Irvine to Test First in Class Dual Target Vaccine
9. Oxitec Responds to University of Panamas Forum on Transgenic Mosquitoes
10. Valkee and University of Oulu Publish the First Clinical Trial on Bright Light Therapy Channeled via ear Canals in Seasonal Depression
11. EUR 1.0 Million Grant Awarded to Exosome Diagnostics and Ludwig Maximilian University from German Federal Ministry for Education and Research to Develop Biofluid-Derived Exosome Diagnostics
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
University of Utah chemists use nanopores to detect DNA damage
(Date:1/22/2015)... Jan. 22, 2015   GenoSpace , a precision medicine software ... enable the broad use of genomic, imaging and other biomedical ... of Michelle Munson , CEO of Aspera, an IBM ... Logo - http://photos.prnewswire.com/prnh/20150122/170713 "We are ...
(Date:12/24/2014)... NEW YORK , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, ... in critical areas, announced the closing of an underwritten public ... purchase up to an aggregate 3,500,000 shares of common stock, ... per warrant.  The warrants have a per share exercise price ...
(Date:12/24/2014)... 2014 GMO corn cases filed across the ... the process of being consolidated in a Kansas federal court ... AG MIR 162 Corn Litigation, MDL No. 2591 in the ... of the Syngenta GMO corn multidistrict litigation (MDL) has been ...
(Date:12/24/2014)... Long Island, New York (PRWEB) December 23, 2014 ... , and the Long Island Affiliate of ITRA Global, the ... economy’s slow but steady recovery. This is evidenced by ... and the strong stock market. Low energy costs have ...
Breaking Biology Technology:GenoSpace Expands Board with Appointment of Michelle Munson 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3
... , ... , Chairman of Tech Coast Angels (TCA), the nation,s largest ... program of increased entrepreneur support, communication and mentoring will be overseen by ... constrained economy, entrepreneurs need easier access to viable sources of help and ...
... , Jan. 26 Medical & ... Osaka University, has successfully generated several fully human monoclonal ... by utilizing blood samples from volunteers who were inoculated with ... at the Department of Virology, Research Institute for Microbial Diseases, ...
... , TUALATIN, Ore. , Jan. 26 ... company dedicated to the acquisition, development, and commercialization of ... an agreement with British-based Ingenion Design Ltd. ("Ingenion") to ... Measurement Device (GasPT2). , The GasPT2, designed by GL ...
Cached Biology Technology:Sudek of Tech Coast Angels Announces Network's Increased Commitment to Entrepreneurship and Innovation Through New Easy-Access Programs 2Sudek of Tech Coast Angels Announces Network's Increased Commitment to Entrepreneurship and Innovation Through New Easy-Access Programs 3Sudek of Tech Coast Angels Announces Network's Increased Commitment to Entrepreneurship and Innovation Through New Easy-Access Programs 4Generation of Fully Human Monoclonal Antibodies Neutralizing Influenza Virus - Use of SPYMEG as a novel human lymphocyte fusion partner 2Generation of Fully Human Monoclonal Antibodies Neutralizing Influenza Virus - Use of SPYMEG as a novel human lymphocyte fusion partner 3Waytronx Announces Agreement for Development and Production of Its GASPT2 Device With UK-Based Ingenion Design Limited 2Waytronx Announces Agreement for Development and Production of Its GASPT2 Device With UK-Based Ingenion Design Limited 3Waytronx Announces Agreement for Development and Production of Its GASPT2 Device With UK-Based Ingenion Design Limited 4
(Date:12/17/2014)... 15, 2014 Research and Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ... Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology ... http://photos.prnewswire.com/prnh/20130307/600769 Based on a ... introduces for the first time a fingerprint sensor in ...
(Date:12/17/2014)... fundamentally transforming the travel experience and nowhere is this ... decade, ePassports, biometric readers, and secure document scanners have ... via eGates and Automated Passport Control (APC) Kiosks at ... across the globe. According to ...
(Date:12/11/2014)... PAUL, Minn. , Dec. 10, 2014  Data ... physiologic monitoring, has released a new series of ... of preclinical toxicology researchers. M series, part of ... toxicologists collect the best possible physiologic data when ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2New telemetry implants expected to change how large animal toxicology studies are conducted 2
... The Institute for Research in Biomedicine (IRB Barcelona) has ... two European health research projects, as part of the ... makes IRB Barcelona a leader in European projects in ... all, Spanish centres will be heading ten projects. The ...
... think twice about spending money on a commercial flame ... your tree in a container of fresh wateris probably ... healthy. Researchers have determined that some flame retardants don,t ... cases the chemical retardants sped up the drying process ...
... say "shade grown, please" when you order your morning ... under a canopy of multiple tree species, not only ... also maintain genetic diversity of native tree species and ... The finding comes from a study published by ...
Cached Biology News:IRB Barcelona to coordinate two European projects on biomedicine 2IRB Barcelona to coordinate two European projects on biomedicine 3Flame retardants prove ineffective on fresh-cut Christmas trees 2Shade coffee benefits more than birds 2Shade coffee benefits more than birds 3
Mouse/Rat WNK1 Affinity Purified Polyclonal Ab...
RayBio L Series 507: RayBio Label-based Antibody Array I (2 membranes) Class: Antibody Array Products Product Group: Antibody Array...
... The SYBR Safe photographic filter ... Gels and Blots) is ideal for ... the SYBR Safe DNA gel stain, ... that the SYBR Safe photographic filter ...
Mature rat whole blood (Sprague-Dawley, averaging 7-8 weeks of age, either sex) is collected at the time of slaughter and processed within 45 minutes. It is then filtered through gauze, pooled in an ...
Biology Products: