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University of Toronto chemistry technology promises more effective prescription drug therapies
Date:5/5/2011

s per second by suspending them in a stream of fluid or gas and passing them through an electronic detection apparatus. The two very disparate disciplines previously had no reason to be combined.

The U of T scientists developed the chemistry and methods of attaching the metal atoms necessary for the detection of the vanishingly rare biomolecules of interest at the individual cell level, where personal therapeutic response is defined. They also developed a unique instrument to simultaneously measure a large number of these diagnostic signals for individual cells at a high analysis rate. Garry Nolan, a professor of microbiology and immunology at Stanford University and lead investigator of the research presented in this paper, adapted and expanded his earlier work in flow cytometry to take advantage of the much higher power that mass cytometry provides.

Nolan and his colleagues at Stanford, with collaborators at Columbia, used the U of T technology to monitor 34 different substances found inside and on the surface of different cell types produced in human bone marrow, the place where all immune and blood cells, as well as blood disorders such as leukemia, originate. They were able not only to correctly categorize over a dozen different immune cell types but, at the same time, to peer inside the cells and learn how various internal processes differed from one cell type to the next. "We can tell not only what kind of cell it is but what it's thinking, and what it may become," says Nolan.


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Contact: Sean Bettam
s.bettam@utoronto.ca
416-946-7950
University of Toronto
Source:Eurekalert  

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