Navigation Links
University of Toronto chemistry technology promises more effective prescription drug therapies
Date:5/5/2011

TORONTO, ON Scientists at the University of Toronto, Stanford and Columbia Universities have developed a way to measure the action and function of candidate prescription drugs on human cells, including the response of individual cells, more quickly and on a larger scale than ever before.

The researchers say their "mass cytometry" technology has the potential to transform the understanding of a variety of diseases and biologic actions, and will provide a better tool to understand how a healthy cell becomes diseased. Clarifying the underlying biochemistry of cells may enable earlier detection of illness and ultimately advance personalized medicine, notably for cancer and HIV treatments, by offering more and less aggressive options for treatment.

"We've shown that drug response is specific to certain sub-populations of cells, and gained insight into the signaling cascade that defines that response" says Scott Tanner of U of T's Department of Chemistry, who led the development of the technology used in research to be published this week in Science. "We've also shown that a drug can activate or suppress multiple response pathways simultaneously, and that these responses are modified when a combination of drugs are administered."

"Together, this suggests that the technology will be of significant value in the development and validation of rational drugs to target particular pathogens a quantum step towards the provision of personalized medicine," says Tanner.

Mass cytometry allows simultaneous measurement of as many as 100 biomarkers specific physical traits of cells used to measure or indicate the effects or progress of a disease, illness, or condition in single cells, at 1000 cells per second. It applies the analytical capabilities of atomic mass spectrometry used to measure the number and type of atoms that comprise a sample to the technique of flow cytometry, which is a method of examining thousands of microscopic particle
'/>"/>

Contact: Sean Bettam
s.bettam@utoronto.ca
416-946-7950
University of Toronto
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. University of Maryland School of Medicine publishes scientific paper on 2001 anthrax attacks
2. The University of Maryland Baltimore (UMB) and Paragon Bioservices, Inc. Announce the Formation of a Public-Private Stem Cell Technology Consortium
3. CureFAKtor Pharmaceuticals Featured at University of Florida Innovation Showcase 2011
4. Tomophase Announces First Sale of Its OCT Imaging System (OCTIS™) for Research Use to the University of Texas
5. Nanocrystal doping developed by Hebrew University researchers enhances semiconductor nanocrystals
6. Selexis SA and the University of Lausanne Announce the Complete Sequencing of the Selexis SURE CHO-M Genome
7. China PharmaHub In-Licenses Universal Donor Red Blood Cells Technology Exclusively From University of California, San Diego
8. Mtech Announces Semifinalists for University of Maryland $75K Business Plan Competition
9. University of Maryland School of Medicine publishes scientific paper on 2001 anthrax attacks
10. Queens University professor uses nanotechnology to prolong machine and engine life
11. Binghamton University nanoscientist chosen for the Air Forces Young Investigator Research Program
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
University of Toronto chemistry technology promises more effective prescription drug therapies
(Date:8/22/2014)... particles are intensively investigated for application as ... agents and components in photonics and molecular ... fundamental for understanding physical and chemical properties, ... University, USA, have demonstrated that high-resolution electron ... three-dimensional structure in which all gold atoms ...
(Date:8/22/2014)... -- Research and Markets has announced the ... & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market ... The global molecular biology enzymes market ... expected to grow at a CAGR of 13.74% to ... & reagents find applications in a large number of ...
(Date:8/22/2014)... 22, 2014 “Our nation's healthcare ... a national disgrace. Furthermore, every governmental and professional ... current, deplorable state of unorganized dysfunction shares in ... to merely serve as a device to use ... colossal failure(s) that have accumulated through the years ...
(Date:8/21/2014)... international research team including DESY scientists has observed tiny ... team reports in the journal Science that ... inside the nanodroplets. It is the first time that ... larger samples of what is known as superfluid helium, ... our best expectations," says Andrey Vilesov of the University ...
Breaking Biology Technology:A breakthrough in imaging gold nanoparticles to atomic resolution by electron microscopy 2Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 2Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 35 Great Mistakes in Healthcare and How to Fix Them by Dr. Ira Williams 2Scientists observe quantum vortices in cold helium droplets 2
... , SOUTH SAN FRANCISCO, Calif., July 23 Anesiva, ... its Current Report on Form 8-K filed with the Securities and ... on April 1, 2009, a letter from the NASDAQ Stock Market ... not in compliance with Marketplace Rule 4450(a)(3) (which has since been ...
... , , ANAHEIM, Calif., ... will showcase a wide spectrum of new and updated products that ... the products on display will be a new version of the ... the product,s speed, precision, and clinical flexibility. The new software ...
... , , SUNNYVALE, ... development of endovascular devices for the treatment of chronic total occlusions ... of Chief Operating Officer. Chris previously held the position of Executive ... of experience in Medical Devices including the last 2 years at ...
Cached Biology Technology:Anesiva Receives NASDAQ Delisting Staff Determination Letter 2Anesiva Receives NASDAQ Delisting Staff Determination Letter 3Varian Medical Systems to Showcase a Wide Spectrum of New and Updated Products That Improve Radiotherapy Treatment Processes at 2009 AAPM Meeting 2Varian Medical Systems to Showcase a Wide Spectrum of New and Updated Products That Improve Radiotherapy Treatment Processes at 2009 AAPM Meeting 3Varian Medical Systems to Showcase a Wide Spectrum of New and Updated Products That Improve Radiotherapy Treatment Processes at 2009 AAPM Meeting 4FlowCardia, Inc. Appoints Chris Barys to Chief Operating Officer 2
(Date:8/21/2014)... Algae might seem easy to ignore, but they are ... animals depend upon. Humans are increasingly dependent on algae, ... atmosphere and sink it to the bottom of the ... and laboratory experiments, researchers have evidence showing that viruses ... the algae,s blooms, even when all else stays essentially ...
(Date:8/21/2014)... researchers from Beth Israel Deaconess Medical Center (BIDMC ) ... Most Influential Scientific Minds 2014," a comprehensive list ... web resource for science metrics and research performance analysis. ... most influential "are performing and publishing work that their ... science," according to a Thomson Reuters statement. Researchers were ...
(Date:8/21/2014)... 2014 , WHERE: , San Diego Convention ... 92101 , WHAT: , Invited and platform ... research in human genetics. Examples of sessions include: ... rare genetic variants in health and disease, the ... sensitivity (Saturday, Oct. 18, 5:30-7:30 pm) , Crowdsourced ...
Breaking Biology News(10 mins):Viruses take down massive algal blooms, with big implications for climate 2BIDMC researchers named among 'the most influential scientific minds' 2BIDMC researchers named among 'the most influential scientific minds' 3American Society of Human Genetics 2014 Annual Meeting 2
... A new report launched today by the International Osteoporosis ... Pharmaceutical Industry Associations (EFPIA) reveals that the burden of ... concludes that in Europe,s five largest countries and Sweden ... occurred in 2010 the equivalent of 280 fractures ...
... better ways of encapsulating medicine so that it can reach ... for the first time living human cells to ... agents. The report appears in ACS, journal Nano Letters ... that the human body is very efficient at getting rid ...
... CHICAGO (June 15, 2011) A study of Canadian home-care ... ongoing medical care at home. The study, published in the ... the journal of the Society for Healthcare Epidemiology of America, ... in home-care patients to avoid misuse that could decrease the ...
Cached Biology News:Landmark report reveals immense burden of osteoporotic fractures in Europe 2Study hints at antibiotic overuse in home-care patients 2
... Immunogen: Synthetic peptide derived from the C-terminal ... growth factor D iris-expressed growth factor spinal ... mouse and rat by one amino acid ... kDa human mouse and rat PDGF-D proteins. ...
Antibodies were affinity purified using epitopes specific to USP33 immobilized on solid support....
...
... Fd. ELISA Specificity: (4) ,human IgG subclass 1 ... subclass 3 100% ,human IgG subclass 4 ... 100% ... 0.04% ,human IgG Fab ...
Biology Products: