Navigation Links
University of Toronto chemistry technology promises more effective prescription drug therapies
Date:5/5/2011

TORONTO, ON Scientists at the University of Toronto, Stanford and Columbia Universities have developed a way to measure the action and function of candidate prescription drugs on human cells, including the response of individual cells, more quickly and on a larger scale than ever before.

The researchers say their "mass cytometry" technology has the potential to transform the understanding of a variety of diseases and biologic actions, and will provide a better tool to understand how a healthy cell becomes diseased. Clarifying the underlying biochemistry of cells may enable earlier detection of illness and ultimately advance personalized medicine, notably for cancer and HIV treatments, by offering more and less aggressive options for treatment.

"We've shown that drug response is specific to certain sub-populations of cells, and gained insight into the signaling cascade that defines that response" says Scott Tanner of U of T's Department of Chemistry, who led the development of the technology used in research to be published this week in Science. "We've also shown that a drug can activate or suppress multiple response pathways simultaneously, and that these responses are modified when a combination of drugs are administered."

"Together, this suggests that the technology will be of significant value in the development and validation of rational drugs to target particular pathogens a quantum step towards the provision of personalized medicine," says Tanner.

Mass cytometry allows simultaneous measurement of as many as 100 biomarkers specific physical traits of cells used to measure or indicate the effects or progress of a disease, illness, or condition in single cells, at 1000 cells per second. It applies the analytical capabilities of atomic mass spectrometry used to measure the number and type of atoms that comprise a sample to the technique of flow cytometry, which is a method of examining thousands of microscopic particles per second by suspending them in a stream of fluid or gas and passing them through an electronic detection apparatus. The two very disparate disciplines previously had no reason to be combined.

The U of T scientists developed the chemistry and methods of attaching the metal atoms necessary for the detection of the vanishingly rare biomolecules of interest at the individual cell level, where personal therapeutic response is defined. They also developed a unique instrument to simultaneously measure a large number of these diagnostic signals for individual cells at a high analysis rate. Garry Nolan, a professor of microbiology and immunology at Stanford University and lead investigator of the research presented in this paper, adapted and expanded his earlier work in flow cytometry to take advantage of the much higher power that mass cytometry provides.

Nolan and his colleagues at Stanford, with collaborators at Columbia, used the U of T technology to monitor 34 different substances found inside and on the surface of different cell types produced in human bone marrow, the place where all immune and blood cells, as well as blood disorders such as leukemia, originate. They were able not only to correctly categorize over a dozen different immune cell types but, at the same time, to peer inside the cells and learn how various internal processes differed from one cell type to the next. "We can tell not only what kind of cell it is but what it's thinking, and what it may become," says Nolan.


'/>"/>

Contact: Sean Bettam
s.bettam@utoronto.ca
416-946-7950
University of Toronto
Source:Eurekalert  

Related biology technology :

1. University of Maryland School of Medicine publishes scientific paper on 2001 anthrax attacks
2. The University of Maryland Baltimore (UMB) and Paragon Bioservices, Inc. Announce the Formation of a Public-Private Stem Cell Technology Consortium
3. CureFAKtor Pharmaceuticals Featured at University of Florida Innovation Showcase 2011
4. Tomophase Announces First Sale of Its OCT Imaging System (OCTIS™) for Research Use to the University of Texas
5. Nanocrystal doping developed by Hebrew University researchers enhances semiconductor nanocrystals
6. Selexis SA and the University of Lausanne Announce the Complete Sequencing of the Selexis SURE CHO-M Genome
7. China PharmaHub In-Licenses Universal Donor Red Blood Cells Technology Exclusively From University of California, San Diego
8. Mtech Announces Semifinalists for University of Maryland $75K Business Plan Competition
9. University of Maryland School of Medicine publishes scientific paper on 2001 anthrax attacks
10. Queens University professor uses nanotechnology to prolong machine and engine life
11. Binghamton University nanoscientist chosen for the Air Forces Young Investigator Research Program
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
University of Toronto chemistry technology promises more effective prescription drug therapies
(Date:12/8/2016)... Dec. 8, 2016  OncoSec Medical Incorporated ("OncoSec") ... DNA-based intratumoral cancer immunotherapies, today announced financial results ... "We are delivering on our commitment to ... ImmunoPulse® IL-12. We are pleased with the early ... trial, and we are focused on advancing our ...
(Date:12/8/2016)...  Renova™ Therapeutics, a biotechnology company developing gene ... 2 diabetes, announced that it has obtained a ... vector developed in the laboratory of Professor ... The company plans to use this vector in ... "Early research has shown promise ...
(Date:12/8/2016)... Oxford Gene Technology ... Palette an anpassbaren SureSeq™ NGS-Panels mit dem Start ... ein schnelles und kostengünstiges Studium der Varianten bei ... Erkennung von Einzel-Nukleotid-Variationen (Single Nucleotide Variation, SNV) und ... Panel und ermöglicht eine individuelle Anpassung durch die ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... commercial launch of flexible packaging for their exceptionally efficient human mesenchymal stem/stromal ... extends RoosterBio’s portfolio of bioprocess media products engineered to radically streamline culture ...
Breaking Biology Technology:
(Date:12/7/2016)... , Dec. 7, 2016   Avanade ... successful Formula One teams in history, exploit biometric data ... stop performance and maintain the competitive edge against their ... 2016. Avanade has worked with Williams ... range of biometric data (heart rate, breathing rate, temperature ...
(Date:12/6/2016)... RALEIGH, N.C. , Dec. 6, 2016 ... technology, announced today it has seen a third consecutive ... biometric sensor technology in 2016 with a 360 ... over last year. This increase was driven by sales ... well as robust interest in its technology for hearables ...
(Date:12/2/2016)... , December 1, 2016 ... type (Fingerprint, Voice), Future Technology (Iris Recognition System), ... Region - Global Forecast to 2021", published by ... 442.7 Million in 2016, and is projected to ... a CAGR of 14.06%.      (Logo: ...
Breaking Biology News(10 mins):