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University of Colorado Cancer Center Study Finds That Body's Ibuprofen, SPARC, Reduces Inflammation and Thus Bladder Cancer Development and Metastasis
Date:1/16/2013

seems that surrounding healthy tissue may respond to a growing tumor by increasing SPARC production, which it hopes will mute the tumor. Thus high SPARC that is in fact an attempt at tumor suppression can be coincidentally associated with aggressive tumors when the entire tumor is examined.

Healthy tissue turns up SPARC to mute tumors. Aggressive cancers turn down SPARC to promote tumors.

Then Theodorescu and colleagues turned to animal models without the ability to manufacture SPARC. Not only was bladder cancer quicker to develop in these models, but the cancer was also more likely to travel to invade lung tissue. When SPARC was added to these models, tumor growth and metastasis was reduced.

"This is a comprehensive portrait of SPARC function using human and murine bladder cancer as a model, and the first to clearly distinguish between the role of SPARC generated in the tumor and the role of the protein generated in the surrounding tissue," says Theodorescu. "We hope this provides the rational basis for further exploring manipulation of SPARC as a therapeutic intervention."

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This study was supported in part by NIH grant CA143971

The CU Cancer Center is headquartered on the University of Colorado Anschutz Medical Campus and is a consortium of three state universities (Colorado State University, University of Colorado Boulder and University of Colorado Denver) and six health delivery institutions: University of Colorado Health System (including University of Colorado Hospital, Poudre Valley Hospital and Medical Center of the Rockies), Children’s Hospital Colorado, Denver Health, Denver VA Medical Center, National Jewish Health and Kaiser Permanente Colorado.

Read the full story at http://www.prweb.com/releases/2013/1/prweb10330748.htm.


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