Navigation Links
University of Colorado Cancer Center Review Shows Long-term Side-effects of New, Targeted Therapies in Pediatric Cancer Patients
Date:2/7/2013

Aurora, COLO (PRWEB) February 07, 2013

A University of Colorado Cancer Center review published this week in the journal Lancet Oncology describes possible long-term side-effects of new, targeted therapies in pediatric cancer patients: what we don’t know may hurt us.

“As pediatricians who treat kids with cancer, we expect the side-effects of traditional chemotherapies: low white blood count, infections, even long-term heart trouble or infertility. But there’s the impression that these new, molecularly targeted agents are much less toxic. That may be true, especially in adult patients, but until we have more information about the long-term effects of these therapies in children, we need to be careful about how and when we prescribe them,” says Chris Porter, MD, CU Cancer Center investigator and assistant professor of Pediatrics at the University of Colorado School of Medicine.

Already we know that molecularly targeted therapies may stunt the growth of pediatric patients, delay puberty or speed the onset of diabetes. And researchers are just now starting to ask about additional, sometimes unforeseen side-effects, potentially including more subtle issues such as neurocognitive, balance and motor defects.

“The growth of cancer cells isn’t that different than the growth of a 7-pound baby into a 210-pound teenage linebacker. Now, you shut down these growth pathways in an adult and it might not be a big deal, but you shut down these same pathways at a critical time in childhood development and you can have real problems,” says Lia Gore, MD, CU Cancer Center investigator and associate professor of Pediatrics and Medical Oncology at the CU School of Medicine.

The practical problem is this: FDA approval of many of these drugs for adult use allows physicians to prescribe the same drugs for pediatric use. Many are pills – orally administered, outpatient treatments that make it difficult to recognize and track p
'/>"/>

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Page: 1 2

Related biology technology :

1. Elsevier and Kanazawa University in Japan Collaborate to Map Universitys Research Performance
2. Two University of Colorado Cancer Center Studies Show that Silibinin, Found in Milk Thistle, Protects Against UV-Induced Skin Cancer
3. WaferGens MyDesign Open Platform Facilitates Rapid Development of a Proprietary Prostate Cancer Diagnostic Panel in the Lab of Dr. Arul Chinnaiyan at the University of Michigan Cancer Center
4. NextBio Teams With Emory University and the Aflac Cancer Center to Improve Outcomes for Children with Medulloblastoma
5. Notre Dame to be part of $194 million university research center network
6. University of Minnesota awarded $28 million grant to lead microelectronics development
7. Krishagni Enables University of New South Wales (Australia) to Adopt caTissue Plus
8. University of Colorado Cancer Center Study Finds That Body's Ibuprofen, SPARC, Reduces Inflammation and Thus Bladder Cancer Development and Metastasis
9. Rice University discovers that graphene oxide soaks up radioactive waste
10. Carin Grings remains identified by researchers at Uppsala University
11. Nanonex Delivered Advanced Nanoimprint Tool NX-B200 to Swinburne University of Technology, Australia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/26/2014)... 26, 2014 In keeping with the ... a bevy of last-minute Thanksgiving savings. The company is ... across all product lines this holiday weekend as well ... Black Friday, and Cyber Monday are right around the ... to both loyal customers and those looking to explore ...
(Date:11/26/2014)... Nov. 26, 2014 The Alliance ... a survey of European physicians at the "1 ... and Biological Therapies" at the Spanish Ministry of ... by EuropaBio and the Spanish Bioindustry Association (ASEBIO), ... physicians from Spanish oncology and rheumatology societies, representatives ...
(Date:11/26/2014)... 26, 2014 PMG Research, Inc. ... Research is a network of sites that provide clinical research ... 2 million patient lives through its partnerships with large physician ... 11 hub site locations in the Southeastern United States and ... of the board will be held by: Dr. ...
(Date:11/26/2014)... Silicon Valley Electronic Data Capture (EDC) ... Alliance , provider of clinical research and data management ... addition to its CRO Partnership Program, Clinovo expands ... India. , “We have found Clinovo’s ClinCapture to ... platform which is both user friendly and easy to ...
Breaking Biology Technology:DNA Spectrum Offers Last Minute Thanksgiving Coupons 2DNA Spectrum Offers Last Minute Thanksgiving Coupons 3ASBM Presents European Physicians Survey at Spanish Ministry of Health 2PMG Research Names Medical Advisory Board 2PMG Research Names Medical Advisory Board 3RPM Alliance Joins Clinovo’s CRO Partnership Program, Further Strengthening Its Presence in Southern California and India 2
... a subsidiary of MGT Capital Investments, Inc. (NYSE Alternext ... of Computer-Aided Detection (CAD) and image analysis software which ... is pleased to announce it has launched ColonCAD API ... today at the European Congress of Radiology (ECR 2009) ...
... All amounts are in US dollarsQUEBEC CITY, March ... AEZS ; TSX: AEZ), a global biopharmaceutical ... announced the signing of a development, commercialization and ... SNY ) for the development, registration and ...
... in the two years since its discovery, has spread to ... half a million bats. Now researchers have suggested the first ... bats: providing localized heat sources to the hibernating animals. ... says Justin Boyles, a graduate student in biology at Indiana ...
Cached Biology Technology:Medicsight Unveils New Version of ColonCAD(TM) at ECR 2009 2Medicsight Unveils New Version of ColonCAD(TM) at ECR 2009 3AEterna Zentaris and Sanofi-Aventis Sign a Development, Commercialization and Licensing Agreement for Cetrorelix in Benign Prostatic Hyperplasia 2AEterna Zentaris and Sanofi-Aventis Sign a Development, Commercialization and Licensing Agreement for Cetrorelix in Benign Prostatic Hyperplasia 3AEterna Zentaris and Sanofi-Aventis Sign a Development, Commercialization and Licensing Agreement for Cetrorelix in Benign Prostatic Hyperplasia 4AEterna Zentaris and Sanofi-Aventis Sign a Development, Commercialization and Licensing Agreement for Cetrorelix in Benign Prostatic Hyperplasia 5Ecologists propose first prevention for white-nose syndrome death in bats 2Ecologists propose first prevention for white-nose syndrome death in bats 3
(Date:11/4/2014)... (Philadelphia, PA) – Temple University School of Medicine ... Explorations winner, an initiative funded by the Bill ... MPH, Professor of Obstetrics, Gynecology and Reproductive Sciences; ... at Temple University School of Medicine will pursue ... titled "Maternal Blood Biomarkers to Assess Fetal Neurodevelopment.", ...
(Date:11/4/2014)... 2014   3D ... Fuel3D , a developer of 3D scanning ... totaling $6.4 million (£4 million). This funding builds on the ... year and paves the way for the commercial launch of ... funding round was led by Chimera Partners and will be ...
(Date:11/3/2014)... Research and Markets has announced the addition of ... Companies" to their offering. This report ... already started to play an important role in the practice ... fashioned bone marrow transplants. Role of cells in drug discovery ... part of medical practice. Stem cells are discussed ...
Breaking Biology News(10 mins):Temple University School of Medicine receives Grand Challenges Explorations grant 2Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 2Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 3
... February 23, 2009 - A new study by ... Panel on Climate Change (IPCC) 2001 Third Assessment Report ... average global temperatures due to greenhouse gas emissions could ... concern. The study, published in the Proceedings of ...
... California Institute of Technology (Caltech) and the University of ... theoretical modeling and Caltech experimental data to show just ... functional proteins. Their insights were recently published in ... the National Academy of Sciences (PNAS). The ...
... Maybe. A team of European scientists have finally solved a ... gray. Despite the notion that gray hair is a sign of ... The FASEB Journal ( http://www.fasebj.org ) that wisdom has ... massive build up of hydrogen peroxide due to wear and tear ...
Cached Biology News:Lower increases in global temps could lead to greater impacts than previously thought, study finds 2Lower increases in global temps could lead to greater impacts than previously thought, study finds 3Caltech and UCSD researchers shed light on how proteins find their shapes 2No longer a gray area: Our hair bleaches itself as we grow older 2
Recombinant Ovine (Sheep) Prolactin, Ultra Pure...
Human SCP3 Affinity Purified Polyclonal Ab Keywords: Spermatogenesis, meiosis Protein Family: Cell Cycle...
Homo sapiens alcohol dehydrogenase 5 (class III), chi polypeptide (ADH5), mRNA....
Human Rad1 MAb (Clone 33)...
Biology Products: