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Under the Microscope: 'Micro IVF'

MDs Debate Effectiveness of 'Micro IVF,' also referred to as 'Mini IVF' or 'Minimal Stimulation IVF' at

LOS ANGELES, April 28 /PRNewswire/ -- Several esteemed reproductive endocrinologists are now weighing in at on the subject of the new "Micro IVF," also called "Mini IVF" or "Minimal Stimulation IVF." FertilityTies is the only comprehensive online community and social network providing 24-7-365 support on fertility matters, connecting members with peers as well as accredited medical professionals. The physicians who have expressed their opinions discuss the effectiveness of a procedure that was designed to be recession-savvy because it cuts down on time and medication costs required for conventional IVF.

Micro IVF can be described as taking only oral fertility medications with or without minimal use of injectable gonadotropins when going through In Vitro fertilization. The process then proceeds in similar fashion to conventional IVF with egg retrieval, fertilization, embryo culture and embryo transfer. This new protocol is said to not only cut down on costs, but to diminish risks of multiple births.

Following are the opinions expressed by Reproductive Endocrinologists at, (It should be noted that FertilityTies does not promote specific fertility treatment but provides information from all sides so members can be informed):

I. Dr. Rudy Quintero, M.D., F.A.C.O.G. (on the CON side of the debate) Founder and Medical Director of C.A.R.E. Fertility in Los Angeles, CA.

"IVF over the past twenty years has evolved and been optimized from a point where pregnancy rates were at best quoted to be 10% back then to about 50% today. We have become better with stimulation protocols and techniques over this time period. Nevertheless, this success has unintended consequences including the possibility of embryo overproduction and multiple births.

Minimal Stimulation IVF is currently being touted as a solution for this, and we all hope that it soon will be. However, we lack sufficient data from clinical trials to support its use. In one of the better trials to date from Pelinck et al (Netherlands), an 8% pregnancy rate was noted, with a 20.8% pregnancy rate after three attempts with Minimal Stimulation IVF. Some authors have published success rates of up to 40% using Minimal Stimulation IVF, but percentages may be influenced by bias and other study errors due to their retrospective design.

More data needs to become available to truly assess the success of this protocol for different types of patients."

II. Dr. David Kreiner, MD, F.A.C.O.G. (PRO Micro IVF), Medical Director of East Coast Fertility in NYC.

"Micro IVF is a great way to assist patients with achieving their goal of having a single baby while minimizing their risk of complications such as multiple pregnancy, hyper-stimulation syndrome or producing financial hardship. Its lower cost and risk should outweigh diminished pregnancy rate which for young high responders and older poor responders will be minimal. The reason these groups would see a minimal decrease in success is that the younger high responders have a higher implantation rate per embryo and do not need as many embryos to produce the healthy one that will result in a baby. The older poor responders do not make extra embryos with aggressive stimulation and have nothing to gain by adding gonadotropins in a conventional IVF cycle."

III. Dr. Eva Littman, M.D., F.A.C.O.G. (CON)

Founder & Medical Director of Red Rock Fertility in Las Vegas.

"My biggest fear is that this procedure will be misused by couples and patients who require conventional IVF, but because of the economy they opt for the lower price and subsequently, the lower chance of success. It worries me that in order to try to save money, patients may fall for a 'gimmick' and use up funds that could have gone towards a real chance at success."

For more information about "Micro IVF" and the debate surrounding the new protocol, visit Those interested in attending FertilityTies' June 6th convention at The Hilton New York Hotel, where more information about "Micro IVF" and other timely topics (including Infertility Treatments & Ethics in the Wake of the Octuplets, The Controversy of "Designer Babies," Effectiveness of Egg Freezing, Pre-Implantation Genetic Diagnostic/embryo screening, and Benefits of Acupuncture & Herbal Medicines for Fertility) will be discussed, can sign up at the web site.

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