Navigation Links
UTSA/UTHSCSA publish results on bio-threat agent

San Antonio (June 30, 2008) Researchers at The University of Texas at San Antonio (UTSA) South Texas Center for Emerging Infectious Diseases and The University of Texas Health Science Center at San Antonio (UTHSCSA) have identified a cell type believed to play a role in controlling the early infectious process against Francisella tularensis, a respiratory pathogen and bioterrorism agent that is the cause of tularemia. The findings will be released this week in a journal article in the Proceedings of the National Academy of Sciences.

The organism is considered to be a life-threatening bioterrorism agent by the Centers for Disease Control. Tularemia is an illness caused primarily by bites or scratches from rabbits, rodents and hares. In most cases, the bacterium causes relatively benign fever, chills and headaches that can be treated with antibiotics. However, when spread by aerosol, the organism can cause severe respiratory illness and systemic infections and is associated with a 30-40 percent mortality rate.

"We have found that mast cells, historically associated with allergic conditions and asthma, may also be involved in priming innate and adaptive immunity against tularemia," said Bernard Arulanandam, UTSA College of Sciences immunologist and associate professor of biology. "Our studies show that mast cells can interact with other cells and control the number of bacteria that replicate. This opens up a new dimension into how we look at mast cells against this organism, Francisella tularensis."

In 2005, the Department of Health and Human Services awarded UTSA's South Texas Center for Emerging Infectious Diseases a five-year $6.4 million grant to study tularemia.

Collaborators in the published study include Jyothi Ketavarapu, Annette Rodriguez, Karl Klose, Neal Guentzel, Thomas Forsthuber, Jieh-Juen Yu, Yu Cong, Ashlesh Murthy, and Bernard Arulanandam at UTSA, and Mike Berton with The UTHSCSA.

"I think this journal article shows the quality of the researchers that we have managed to attract to UTSA and we should be proud that important research is taking place on our campus as opposed to at a medical school someplace else," said Karl Klose, executive director of the South Texas Center for Emerging Infectious Diseases. "This is really a move in the right direction towards developing this university into a premier research institution."


Contact: Marianne Lewis
University of Texas at San Antonio

Related biology technology :

1. UTSA/UTHSCSA publish results on bio-threat agent
2. UTSA/UTHSCSA publish results on bio-threat agent
3. Tengion Scientists Publish Positive Preclinical Findings With Neo-Organ Demonstrating Long-term Durability and Growth With Skeletal Maturation
4. Sigma-Aldrich(R) Becomes First Life Science Company to Publish in Peer-Reviewed Video Journal JoVE
5. Sigma-Aldrich(R) Becomes First Life Science Company to Publish in PubMeds Peer-Reviewed Video Journal JoVE
6. More Evidence Published That Epidemics of Childhood Obesity, Type 2 Diabetes and Metabolic Syndrome are Linked to Immunization
7. PTC124 Shows Promising Activity in Cystic Fibrosis; Phase 2 Proof-of-Concept Data Published in the Lancet
8. The Scientific Business of Thomson Reuters Publishes Its 2008 Liquent Regulatory Affairs Trends Survey Results
9. Results of Study in Pre-School Children Published in Clinical Pediatrics Adds to Support for Importance of Dietary DHA Intake
10. The Protein Tomography(TM) Award Now Published on Sidecs Homepage
11. Regado Biosciences REG1 Anticoagulation System Study Results Published in the Journal of Thrombosis and Haemostasis
Post Your Comments:
(Date:11/24/2015)... , ... November 24, 2015 , ... Whitehouse Laboratories is ... The new stand-alone facility will be strictly dedicated to basic USP 61, USP ... existing clients the chance to have complete chemistry and micro testing performed by one ...
(Date:11/23/2015)... Nov. 23, 2015 China Cord Blood Corporation ... leading provider of cord blood collection, laboratory testing, hematopoietic ... announced its preliminary unaudited financial results for the second ... September 30, 2015. --> ... , Revenues for the second quarter of fiscal 2016 ...
(Date:11/23/2015)... and PISCATAWAY, New Jersey , ... Crystallographic Data Centre (CCDC) announces the launch ... Database (CSD) and the CSD-System, now complemented by ... CSD-Discovery to support the discovery of new molecules, ... CSD-Enterprise, the complete set of the CCDC,s applications ...
(Date:11/23/2015)... , Nov. 23, 2015  Oxis Biotech, Inc. ... Inc. [OTC: OXIS] and [Euronext Paris: OXI.PA] announced ... Masonic Cancer Center received notification from the U.S. ... proceed with their planned combination Phase 1/Phase 2 ... rights to develop and commercialize OXS-1550, a novel ...
Breaking Biology Technology:
(Date:11/17/2015)... , Nov. 17, 2015  Vigilant Solutions announces ... joined its Board of Directors. --> ... after recently retiring from the partnership at TPG Capital, ... companies with over $140 Billion in revenue.  He founded ... across all the TPG companies, from 1997 to 2013.  ...
(Date:11/12/2015)...   Growing need for low-cost, easy to ... paving the way for use of biochemical sensors ... in clinical, agricultural, environmental, food and defense applications. ... medical applications, however, their adoption is increasing in ... emphasis on improving product quality and growing need ...
(Date:11/9/2015)... Nov. 9, 2015  Synaptics Inc. (NASDAQ: SYNA ... announced broader entry into the automotive market with a ... the pace of consumer electronics human interface innovation. Synaptics, ... ideal for the automotive industry and will be implemented ... Europe , Japan , ...
Breaking Biology News(10 mins):