Navigation Links
USDA scientists discover how foot-and-mouth disease virus begins infection in cattle
Date:12/14/2010

This release is available in Spanish.

U.S. Department of Agriculture (USDA) scientists have identified the primary site where the virus that causes foot-and-mouth disease (FMD) begins infection in cattle. This discovery could lead to development of new vaccines to control and potentially eradicate FMD, a highly contagious and sometimes fatal viral disease of cloven-hoofed animals that is considered the most economically devastating livestock disease in the world.

The discovery was made by scientists with the Agricultural Research Service (ARS) Foreign Animal Disease Research Unit at the Plum Island Animal Disease Center at Orient Point, N.Y. ARS is USDA's principal intramural scientific research agency, and this research supports the USDA priority of promoting international food security.

Veterinary medical officer Jonathan Arzt, research leader Luis Rodriguez and microbiologist Juan Pacheco found that after just six hours of exposure to the FMD virus through the cow's nasal passages, the virus selectively infects epithelial cells in the nasopharynx, a specific region of the back of the cow's throat.

"Because we have determined the actual route the FMD virus takes in infected cattle, we can now begin to target the virus-host interaction in an effort to develop better vaccines and biotherapeutic countermeasures against the disease," Arzt said.

Although the United States has not had an FMD outbreak since 1929, the disease is still considered a serious threat. Epidemics in other countries have resulted in the slaughter of millions of infected and uninfected animals to prevent the virus from spreading. Outbreaks of this disease in previously FMD-free countries could cause billions of dollars in economic losses related to eradication efforts and trade bans.

Vaccines that offer temporary immunity for livestock have been developed, but there is no universal FMD vaccine against the disease. Because there are seven different types of FMD viruses and more than 60 subtypes, vaccines must be highly specific, matched to the type and subtype present in the area of an outbreak, to protect animals against developing clinical signs of disease. Blocking the initial site of infection may be the most effective way to achieve complete protection.

The research was published in the November issue of Veterinary Pathology and featured on the cover of that issue.

The findings have allowed Arzt and his colleagues to answer some basic, yet long-standing mysteries regarding how the FMD virus first invades and propagates in susceptible cattle. The scientists now are conducting further research to answer questions about why the particular epithelial cells are susceptible, and how the initial infection site can be blocked.

"The answers to these questions will result in a new era of FMD prevention in which highly effective vaccines will provide rapid and long-lasting immunity to even the most virulent strains of FMD virus," Arzt said.


'/>"/>

Contact: Sandra Avant
Sandra.Avant@ars.usda.gov
301-504-1627
United States Department of Agriculture -- Research, Education and Economics
Source:Eurekalert

Related biology technology :

1. Clemson scientists put a (nano) spring in their step
2. City of Hope Helps KGI Launch New Management Training Program for Scientists
3. University of Pennsylvania scientists move optical computing closer to reality
4. Scientists grow nanonets able to snare added energy transfer
5. The National Cancer Institute Joins the Global Community of Scientists Now Using BIOMARKERcenter From Thomson Reuters
6. Scientists peel away the mystery behind golds catalytic prowess
7. SACHEM Launches 2-D HPLC e-Learning Program : New e-Learning Program Teaches Scientists How to Better Analyze and Prove Product Purity Through Greater Sensitivity and Precision in Identification of Trace Components
8. Vermillion and Stanford Scientists Receive Best Research Award From the PAD Coalition
9. Brewing better beer: Scientists determine the genomic origins of lager yeasts
10. Tengion Scientists Publish Positive Preclinical Findings With Neo-Organ Demonstrating Long-term Durability and Growth With Skeletal Maturation
11. CU scientists create worlds thinnest balloon -- just one atom thick
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... 5, 2016 On Thursday, February 11, ... for community, health and disaster services, and the ... to enhance care coordination and service delivery for the ... need and to better connect service providers to the ... San Diego has handled more than ...
(Date:2/5/2016)... , Feb. 5, 2016 Australian-US drug discovery and ... today the appointment of a new Chairman, Mr John ... , effective immediately. James Garner , has ... Director and former Acting CEO, Mr Iain Ross , ... Director. --> James Garner , has also been ...
(Date:2/4/2016)... -- - New FDA action date of July ... date of July 22, 2016   --> ... 2016   - Lifitegrast has the potential ... the treatment of signs and symptoms of dry eye disease in ... be the only product approved in the U.S. in the past decade indicated for the ...
(Date:2/4/2016)... ... February 04, 2016 , ... Shimadzu ... quad LC-MS, host live demos and poster sessions, and present on the analysis ... conference takes place March 6 to 10 at the Georgia World Congress Center ...
Breaking Biology Technology:
(Date:2/1/2016)... Fla. , Feb. 1, 2016  Wocket® smart wallet ( www.wocketwallet.com ... and television personality, Joey Fatone . Las Vegas ... greet fans. --> Las Vegas , where ... --> The new video ad was filmed at the Consumer ... appeared at the Wocket booth to meet and greet fans. ...
(Date:1/27/2016)... 2016  Rite Track, Inc. a leading semiconductor equipment ... Chester, Ohio announced today the acquisition of PLUS ... in Austin, Texas , will significantly ... modifications, installations and technical support offerings for TEL Track ... commented, "PLUS has provided world class service including refurbishment, ...
(Date:1/25/2016)... , Jan. 25, 2016  Glencoe Software, the ... pharma and publication industries, will provide the data management ... Centre (NPSC). ... Phenotypic analysis measures ... whole organisms, allowing comparisons between states such as health ...
Breaking Biology News(10 mins):