Navigation Links
USC researchers derive first embryonic stem cells from rats
Date:12/24/2008

nd to develop animals with conditions that mimic important human diseases.

The first ES cell lines were established from mice in 1981 by Martin Evans of Cardiff University, UK, who was last year awarded the Nobel Prize in Medicine or Physiology. Researchers have long been working on establishing rat ES cells, but faced technical hurdles because the conventional methods developed for the derivation of mouse cells did not work in rats.

Building on recent research into how ES cells are maintained, the USC researchers found that rat ES cells can be efficiently derived and grown in the presence of the "3i medium," which consists of molecules that inhibit three specific gene signaling components (GSK3, MEK and FGF receptor kinase). This approach insulates the stem cell from signals that would normally cause it to differentiate, or turn into specialized types of body cells. By blocking these signals, Ying and colleagues found that stem cells from rats, which have previously failed to propagate at all, could be grown indefinitely in the laboratory in the primitive embryonic state.

An accompanying study led by researchers at the University of Cambridge, U.K., reported similar findings, independently verifying that authentic ES cells can be established from rats. Both papers will be published in the upcoming issue of Cell.

"The development of rat embryonic stem cells, long sought by researchers around the world, is a major advance in biomedical science," says Martin Pera, Ph.D., director of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC. "These new stem cell lines will make a huge contribution to basic and applied research and drug development, by providing a technology platform for facile genetic manipulation of a mammalian species that is widely used in academic and industrial labs studying physiology, pathology and pharmacology."

Until now, authentic ES cells have never been establis
'/>"/>

Contact: Sara Reeve
sara.reeve@keck.usc.edu
323-442-2473
University of Southern California
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Clemson researchers advance nanoscale electromechanical sensors
2. Duke researchers coax bright white light from unexpected source
3. Pitt researchers create nontoxic clean-up method for potentially toxic nano materials
4. USC researchers print dense lattice of transparent nanotube transistors on flexible base
5. J. Craig Venter Institute Researchers Publish Significant Advance in Genome Assembly Technology
6. Virginia Tech researchers discover how mosquitoes avoid succumbing to viruses they transmit
7. Alfred Mann Foundation for Biomedical Engineering Launches New Web Site Designed to Help University Researchers Bring Biomedical Advances to Market
8. 2010 Japan Prize to Honor Scientists and Researchers in Industrial Production/Production Technology and Biological Production/Environment Fields
9. Clemson researchers advance nanoscale electromechanical sensors
10. Researchers discover method for mass production of nanomaterial graphene
11. VAP(R) Cholesterol Test Helps Researchers Identify Treatment Effects of Combination Therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 Date: ... p.m. , Location: Warrington Country Club, 1360 Almshouse Road, Warrington, ... only national nonprofit organization solely dedicated to finding a cure ... those affected worldwide, will host its annual Crystal Ball on ...
(Date:1/14/2014)... 2014 Histogen, Inc., a regenerative medicine ... grown under simulated embryonic conditions, today announced that they ... Medical, Inc. for physician-dispensed aesthetic products containing Histogen’s proprietary ... agreement is an amendment to the existing license between ...
(Date:1/14/2014)... As pet owners drew up their lists of New Year,s resolutions ... care of my furry companion." Nowadays there are pet salons, dog ... to take the little canine or feline darlings along wherever mommy ... some pricey toys at the pet store. But anyone who has ...
(Date:1/14/2014)... 14, 2014 The largest international professional organization ... and therapeutic derivatives thereof has endorsed an educational ... about the challenges of adulterated herb and botanical ... The Society for Medicinal Plant and ...
Breaking Biology Technology:Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8
... Emphasis on Drug Development and Recent ... Private Equity ... (Nasdaq: LXRX ) announced several changes to the,composition of ... and the completion of a major strategic financing,with Invus, LP. ...
... Sept. 25 NanoBio(R) Corporation, a,biopharmaceutical company developing ... prevent serious infections, today announced,the addition of four ... Lyou-fu Ma, PharmD, Ph.D.; Susan Ciotti, Ph.D.; Robert ... NanoBio in developing and commercializing,its novel topical anti-infectives ...
... SeqWright, Inc., an international,leader in the field ... Applied Biosystems (ABI) to purchase ABI,s next generation,SOLiD(TM) ... to offer commercial access to the latest in ... between,SeqWright and ABI that grows stronger with time. ...
Cached Biology Technology:Lexicon Appoints Judith Swain, M.D. to Board of Directors 2Lexicon Appoints Judith Swain, M.D. to Board of Directors 3Lexicon Appoints Judith Swain, M.D. to Board of Directors 4NanoBio Expands Drug Development Team for Its Anti-Infective Products 2NanoBio Expands Drug Development Team for Its Anti-Infective Products 3SeqWright Unveils ABI SOLiD(TM) Next Generation Genetic Analysis System 2
(Date:4/23/2014)... the Indiana University School of Public Health-Bloomington has bolstered ... by finding a strong association between heme iron, found ... , The study found that heme iron consumption increased ... while no association was found between nonheme iron, which ... heart disease. , The study was published online ahead ...
(Date:4/23/2014)... available in French and Spanish . ... April 2014Today, the CEC released its Conservation Assessment for ... to Conservation, which identifies 29 priority conservation areas in ... 11 different protected areas in the states of Texas, ... arid and semi-arid habitats inhabited by rare and endangered ...
(Date:4/23/2014)... evidence that the source of a unique rhythmic sound, ... the "bio-duck," is the Antarctic minke whale ( Balaenoptera ... in the 1960s who thought it sounded like a ... locations in the Southern Ocean, but its source has ... an international team of researchers deployed acoustic tags on ...
Breaking Biology News(10 mins):Study: Iron consumption can increase risk for heart disease 2Conservation priorities released for several protected areas along US-Mexico border 2Conservation priorities released for several protected areas along US-Mexico border 3Scientists identify source of mysterious sound in the Southern Ocean 2Scientists identify source of mysterious sound in the Southern Ocean 3
... another reason why you should listen to your mother ... a chemical present at high levels in a precursor ... etc.), helps prevent the severe blistering and skin breakage ... disease epidermolysis bullosa simplex (EBS). The researchers treated ...
... Colorado at Boulder team excavating an ancient Maya village in ... has discovered an ancient field of manioc, the first evidence ... The manioc field was discovered under roughly 10 feet ... been directing the excavation of the ancient village of Ceren ...
... Researchers from Boston University School of Medicine (BUSM) ... HIV disease progression in HIV-infected persons. The study ... Journal of Acquired Immune Deficiency Syndromes., Alcohol use ... on HIV disease progression has been examined in ...
Cached Biology News:Natural chemical found in broccoli helps combat skin blistering disease 2CU-Boulder team discovers first ancient manioc fields in Americas 2CU-Boulder team discovers first ancient manioc fields in Americas 3Study shows link between alcohol consumption and hiv disease progression 2
Mouse monoclonal [1-N-14] to Adenovirus Type 7 hexon C11 Immunogen: Purified Adenovirus type 7 Specificity: This antibody is specific for Adenovirus type 7 hexon C11....
... epitope is specific for Kir2.1 and ... known protein.,SPECIES REACTIVITIES: The immunogen ... porcine and guinea pig. It is ... (17/19 residues) and chick (15/19 residues). ...
Request Info...
... is the main excitatory neurotransmitter in the ... considered to act only on the ligand-gated ... that are involved in the fast excitatory ... to regulate enzymes producing second messengers via ...
Biology Products: