Navigation Links
UO-Berkeley Lab unveil new nano-sized synthetic scaffolding technique
Date:9/2/2014

EUGENE, Ore. -- Scientists, including University of Oregon chemist Geraldine Richmond, have tapped oil and water to create scaffolds of self-assembling, synthetic proteins called peptoid nanosheets that mimic complex biological mechanisms and processes.

The accomplishment -- detailed this week in a paper placed online ahead of print by the Proceedings of the National Academy of Sciences -- is expected to fuel an alternative design of the two-dimensional peptoid nanosheets that can be used in a broad range of applications. Among them could be improved chemical sensors and separators, and safer, more effective drug-delivery vehicles.

Study co-author Ronald Zuckermann of the Molecular Foundry at Lawrence Berkeley National Laboratory (LBNL) first developed these ultra-thin nanosheets in 2010 using an air-and-water combination.

"We often think of oil on water as something that is environmentally bad when, in fact, my group over the past 20 years has been studying the unique properties of the junction between water and oil as an interesting place for molecules to assemble in unique ways -- including for soaps and oil dispersants," said Richmond, who holds a UO presidential chair. "This study shows it is also a unique platform for making nanosheets."

Lead authors on the project were Ellen J. Robertson, a doctoral student in Richmond's lab at the time of the research, and Gloria K. Oliver, a postdoctoral researcher at LBNL. Robertson is now a postdoctoral researcher at LBNL.

Work in Richmond's lab helped to identify the mechanism behind the formation of the nanosheets at an oil-water interface.

"Supramolecular assembly at an oil-water interface is an effective way to produce 2D nanomaterials from peptoids because that interface helps pre-organize the peptoid chains to facilitate their self-interaction," said Zuckermann, a senior scientist at LBNL's Molecular Foundry in a news release. "This increased understanding of the peptoid assembly mechanism should enable us to scale-up to produce large quantities, or scale- down, using microfluidics, to screen many different nanosheets for novel functions."

Zuckermann and Richmond are the corresponding authors on the paper. Additional co-authors are Menglu Qian and Caroline Proulx, both of LBNL.

Like natural proteins, synthetic proteins fold and conform into structures that allow them to do specific functions. In his earlier work, Zuckermann's team at LBNL's Molecular Foundry discovered a technique to synthesize peptoids into sheets that were just a few nanometers thick but up to 100 micrometers in length. These were among the largest and thinnest free-floating organic crystals ever made, with an area-to-thickness equivalent of a plastic sheet covering a football field.

"Peptoid nanosheet properties can be tailored with great precision," Zuckermann says, "and since peptoids are less vulnerable to chemical or metabolic breakdown than proteins, they are a highly promising platform for self-assembling bio-inspired nanomaterials."

To create the new version of the nanosheets, the research team used vibrational sum frequency spectroscopy to probe the molecular interactions between the peptoids as they assemble at the oil-water interface. The work showed that peptoid polymers adsorbed to the interface are highly ordered in a way that is influenced by interactions between neighboring molecules.

The substitution of oil in place of air creates a raft of new opportunities for the engineering and production of peptoid nanosheets, the researchers said. The oil phase, for example, could contain chemical reagents, serve to minimize evaporation of the aqueous phase or enable microfluidic production.


'/>"/>

Contact: Jim Barlow
jebarlow@uoregon.edu
541-346-3481
University of Oregon
Source:Eurekalert

Related biology technology :

1. A 50-year quest to isolate the thermoelectric effect is now over: Magnon drag unveiled
2. MedTRACK Unveils Partnering Tool for J.P. Morgan Healthcare Conference
3. Wake Forest Baptist Medical Center Unveils Historic World-Class Biotech Research & Innovation Center in Downtown Winston-Salems Growing Piedmont Triad Research Park
4. SPYru™ unveils "The Uberwater"
5. Founder of National Childrens Leukemia Unveiled Non-Embryonic Stem Cell Treatment Promising Cure for Cancer at GIL 2012: Europe
6. Synteract Unveils New Branding at DIA 2012 to Support Enhanced Commercial Strategy
7. ScaleMatrix Leads the Way Unveiling the Industry’s First Transparent Pricing Tool in Private Cloud Offerings
8. UBM Conferences Unveils Details for Upcoming Generics and Biosimilars Conference
9. Opedix® Kinetic Health Gear Unveils New KNEE-Tec™ Knee Support Tights Shown to Reduce Quadriceps Muscle Fatigue and Knee Pain
10. Opedix® Joint Support Compression Apparel Unveils New CORE-Tec™ Shorts, Tested to Improve Core Stability, and Offer Support for Low Back Pain during Athletic Activities
11. Microsoft Unveils Dynamics GP 2013 – A Landmark Release to the ERP Solution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... , ... Researchers at the Universita Politecnica delle Marche in Ancona combed medical ... mesothelioma. Their findings are the subject of a new article on the Surviving Mesothelioma ... in the blood, lung fluid or tissue of mesothelioma patients that can help point ...
(Date:6/23/2016)... 2016 A person commits a crime, and the ... track the criminal down. An outbreak of foodborne ... Administration (FDA) uses DNA evidence to track down the bacteria ... far-fetched? It,s not. The FDA has increasingly used a complex, ... foodborne illnesses. Put as simply as possible, whole genome sequencing ...
(Date:6/23/2016)... 2016   EpiBiome , a precision microbiome engineering ... debt financing from Silicon Valley Bank (SVB). The financing ... advance its drug development efforts, as well as purchase ... "SVB has been an incredible strategic partner to us ... bank would provide," said Dr. Aeron Tynes Hammack ...
(Date:6/23/2016)... NEWPORT BEACH, Calif. , June 23, 2016 /PRNewswire/ ... offering new biological discoveries to the medical community, has ... and co-founder Matthew Nunez . "We ... provide us with the capital we need to meet ... funding will essentially provide us the runway to complete ...
Breaking Biology Technology:
(Date:6/22/2016)... On Monday, the Department of Homeland Security ... solutions for the Biometric Exit Program. The Request for ... (CBP), explains that CBP intends to add biometrics to ... United States , in order to deter visa ... Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
(Date:6/20/2016)... , June 20, 2016 Securus Technologies, ... technology solutions for public safety, investigation, corrections and ... prisons involved, it has secured the final acceptance ... facilities for Managed Access Systems (MAS) installed. Furthermore, ... facilities to be installed by October, 2016. MAS ...
(Date:6/15/2016)... , June 15, 2016 ... market report titled "Gesture Recognition Market by Application Market - Global ... 2016 - 2024". According to the report, the  global ... billion in 2015 and is estimated to grow ... 48.56 billion by 2024.  Increasing application ...
Breaking Biology News(10 mins):