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UNC-led team tests commonly used antibodies
Date:12/6/2010

If a strand of your DNA was stretched out completely, it would be more than six feet long. It's hard to imagine that it can fit inside the nucleus of one of your cells, but that's exactly how it works.

For much of the last century, scientists have been busy figuring out how DNA is packaged in cells, and have found strong indications that the packaging is integral to how DNA works. The packaging comprised mostly of an amino acid molecule called a histone influences the on and off switches of different genes that regulate cellular function and play a role in human diseases ranging from cancer to genetic disorders. Scientists study histones by using antibodies to specific "flavors" of histones that are only very slightly different from one another. The antibodies help to pinpoint what DNA is being packaged by a certain kind of "flavor" of histone, and how that affects gene regulation. Different flavors affect genes differently.

"And this is where it gets complicated," says Jason Lieb, PhD, who led the project. "Many companies make these antibodies that we scientists use in our labs but there are so many different kinds of histones and types of tests we do that it's just not feasible for the companies to anticipate every single way that a given antibody can be used."

This is a problem, explains Lieb, who is a professor of biology at UNC-Chapel Hill and member of UNC Lineberger Comprehensive Cancer Center, since scientists can't be absolutely certain that the antibody is recognizing a specific "flavor" of histone, or one that is very closely related.

"Histones are essentially the key to the DNA library. They tell you which 'shelves' of that library or areas of the genome are open or closed to information moving in and out. But since the differences between the different 'flavors' of histones are often extremely small, and it's likely that an antibody may react with more than one histone or in different ways dependin
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Contact: Ellen de Graffenreid
edegraff@med.unc.edu
919-962-3405
University of North Carolina School of Medicine
Source:Eurekalert

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