Navigation Links
UNC-led team tests commonly used antibodies
Date:12/6/2010

If a strand of your DNA was stretched out completely, it would be more than six feet long. It's hard to imagine that it can fit inside the nucleus of one of your cells, but that's exactly how it works.

For much of the last century, scientists have been busy figuring out how DNA is packaged in cells, and have found strong indications that the packaging is integral to how DNA works. The packaging comprised mostly of an amino acid molecule called a histone influences the on and off switches of different genes that regulate cellular function and play a role in human diseases ranging from cancer to genetic disorders. Scientists study histones by using antibodies to specific "flavors" of histones that are only very slightly different from one another. The antibodies help to pinpoint what DNA is being packaged by a certain kind of "flavor" of histone, and how that affects gene regulation. Different flavors affect genes differently.

"And this is where it gets complicated," says Jason Lieb, PhD, who led the project. "Many companies make these antibodies that we scientists use in our labs but there are so many different kinds of histones and types of tests we do that it's just not feasible for the companies to anticipate every single way that a given antibody can be used."

This is a problem, explains Lieb, who is a professor of biology at UNC-Chapel Hill and member of UNC Lineberger Comprehensive Cancer Center, since scientists can't be absolutely certain that the antibody is recognizing a specific "flavor" of histone, or one that is very closely related.

"Histones are essentially the key to the DNA library. They tell you which 'shelves' of that library or areas of the genome are open or closed to information moving in and out. But since the differences between the different 'flavors' of histones are often extremely small, and it's likely that an antibody may react with more than one histone or in different ways dependin
'/>"/>

Contact: Ellen de Graffenreid
edegraff@med.unc.edu
919-962-3405
University of North Carolina School of Medicine
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry
2. QIAGEN and Abbott Enter Into Agreement on Molecular Tests for HIV, HCV and HPV
3. Prototype Software from Elektas Research Group Takes First Place in Two Autosegmentation Contests at MICCAI 2010
4. New York State Licenses Personalized Prescribing DNA Tests
5. FDA Approves First-of-Its-Kind HIV Test Which Can Detect HIV Days Earlier Than Current U.S. Tests
6. QIAGEN Acquires Comprehensive Portfolio of Molecular Food Safety Tests
7. Updated Online Tutorial for GeneTests
8. bj-diagnostik Renforce le Conseil-client Pour les Tests ADN de Fratrie et de Paternit
9. Peoria Clinical Research Center Tests Investigational Drug to Treat Painful Menstrual Cramps
10. New technology could boost disease detection tests speed and sensitivity
11. 23andMe Tests NFL Players DNA for Athletic Genetic Factors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... 1, 2015 The Dohmen Company today ... Ph.D., MBA as Chief Science Officer (CSO) of ... created role, Dr. Floyd will lead Dohmen,s growing ... of pre-commercial and post approval outsourced services in ... communications.  Dr. Floyd brings decades of experience leading ...
(Date:9/1/2015)... ... 01, 2015 , ... Industry leader iLab Solutions recently announced ... newly-created position, Gibbs will lead iLab’s business operations in the region, with an ... entails not only introducing iLab to potential partners but support and management of ...
(Date:9/1/2015)... 1, 2015 Shire plc (LSE: SHP, ... Mathew to its Board of Directors as a Non-Executive ... Compliance & Risk Committee of the Shire Board. Both appointments ... Sara previously served as Chairman, President and Chief Executive Officer ... During her 12-year tenure at D&B, she helped drive the ...
(Date:8/31/2015)... -- MabVax Therapeutics Holdings, Inc. (OTCQB: MBVX) aclinical stage ... antibody, HuMab 5B1, will be garnering major attention as ... World Molecular Imaging Congress (WMIC) being held in ... the Department of Radiology at Memorial Sloan Kettering Cancer ... MabVax,s lead antibody as a PET imaging agent and ...
Breaking Biology Technology:Dohmen Life Science Services Appoints Eric Floyd, Ph.D. as Chief Science Officer 2Dohmen Life Science Services Appoints Eric Floyd, Ph.D. as Chief Science Officer 3iLab Solutions Hires Gerard Gibbs, Director of Business Development, Asia Pacific 2iLab Solutions Hires Gerard Gibbs, Director of Business Development, Asia Pacific 3Shire Appoints Sara Mathew to Board of Directors 2MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 2MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 3MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 4
... Inc.,(Nasdaq: RDEA ) announced today that Barry D. Quart, PharmD, ... UBS Global Life Sciences Conference, Date: ... Time Location: Grand Hyatt, New York ... Focus Conference, Date: Tuesday, October 7, 2008 ...
... Serve Growing Highly-Potent and Cytotoxic ... ... Pharmatek -- a,pharmaceutical chemistry development organization supporting the,pharmaceutical industry -- ... in San Diego., The 18,000 sq. ft. facility includes ...
... the use of sensors or barcodes at the nanoscale, North ... tiny organic particles, when heated to the proper temperature, bob ... film and then can reversibly recede below the surface when ... of particles to a surface and then sinking them back ...
Cached Biology Technology:Ardea Biosciences to Present at the UBS Global Life Sciences Conference and the Third Annual JMP Securities Healthcare Focus Conference 2Pharmatek Announces Official Opening of New Highly-Potent & Cytotoxic Development and Manufacturing Facility 2NC State engineers discover nanoparticles can break on through 2
(Date:9/1/2015)... MOUNTAIN VIEW, Calif. , Sept. 1, 2015 ... interaction with travelers during airport passenger screening. This ... which the passenger screening process will become unintrusive. ... and pre-clearance based on voluntary background investigations will ... analysis from Frost & Sullivan, Global Airport ...
(Date:8/31/2015)... 31, 2015 Growing need for ... government digitization projects to drive India ... TechSci Research report, " India Biometrics Market Forecast & Opportunities, ... is projected to grow at a CAGR of over 35% ... on account of extensive use of biometric technology in the ...
(Date:8/31/2015)... Research and Markets ( http://www.researchandmarkets.com/research/st5b3m/saudi_arabia ) has announced the ... - Growth, Trends & Forecasts (2014-2020)" report to ... Sensors market is estimated at $0.23 billion by 2018 ... The near future will bring biomedical sensors ... individual. These sensors can be set to trigger alerts ...
Breaking Biology News(10 mins):The Future of Airport Security: Passenger Screening Transitioning Into an Invisible Process 2The Future of Airport Security: Passenger Screening Transitioning Into an Invisible Process 3The Future of Airport Security: Passenger Screening Transitioning Into an Invisible Process 4India Biometrics Market to Grow at Over 35% Through 2020, Says TechSci Research 2India Biometrics Market to Grow at Over 35% Through 2020, Says TechSci Research 3Saudi Arabia Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts (2014-2020) 2
... 03, 2010, Seoul, S. Korea Institut Pasteur Korea ... the chemical compound collection of Novartis Institute for Tropical ... IP-K,s PhenomicScreen is a high-throughput, high-content visual screening ... Over the past year, PhenomicScreen has been used to ...
... Intense, individually tailored dietary treatment for acutely hospitalized elderly ... new study by researchers at Ben-Gurion University of the ... prestigious Journal of the American Geriatric Society ... percent) of the control group compared to the intervention ...
... Several of the most promising technological research projects at ... infusion of federal cash to help them through the ... the commercial market. With $5.1 million in federal ... System of Maryland research institutions and the U.S. Army ...
Cached Biology News:Personalized diets for elderly after hospitalization decreases mortality rates 2$5.1 million Army-Md. alliance speeds university research to market 2$5.1 million Army-Md. alliance speeds university research to market 3$5.1 million Army-Md. alliance speeds university research to market 4$5.1 million Army-Md. alliance speeds university research to market 5
Non-Receptor Tyrosine Kinase Sampler Kit 10 mu g each...
Mouse monoclonal [N7519] to NR0B2 ( Abpromise for all tested applications). Antigen: E.coli expressed recombinant full length protein (Human) NR0B2 Entrez Gene ID: 8431 Swiss Protein ID: ...
DNA Repair Sampler Kit 10g each...
Zonula Adherens Sampler Kit 10 mu g each...
Biology Products: