Navigation Links
UCSF researchers help crack parasite genome, identify drug leads
Date:7/15/2009

>

"That, combined with the extensive collections of compounds at the small-molecule center, has meant that we can now screen large compound collections at a much higher rate than with the more traditional approach of screening adult parasites, either in culture or in small animal models," Caffrey said.

For the genome research, Caffrey and two other UCSF and QB3 researchers, Susan T. Mashiyama, PhD, and Mohammed Sajid, PhD, were asked to contribute to the genome project based on the track record of the Sandler Center's research into the biology and therapeutic potential of parasite proteolytic enzymes.

Directed by James H. McKerrow, MD, PhD, a professor in the UCSF Department of Pathology, the Sandler Center has shown that proteases make excellent drug targets in many parasites and that small-molecule protease inhibitors can limit or cure experimental infections of Chagas' disease, Human African Trypanosomiasis and schistosomiasis. The detailed characterization of the S. mansoni degradome, therefore, may similarly lead to the identification and development of new protease-targeted chemotherapies for schistosomiasis.


'/>"/>

Contact: Kristen Bole
kbole@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Canadian researchers discover gene related to the appearance of aging
2. Researchers enlist DNA to bring carbon nanotubes promise closer to reality
3. Researchers unite to distribute quantum keys
4. Stanford researchers find a quicker, cheaper way to sort isotopes
5. Researchers putting a freeze on oscillator vibrations
6. Researchers solve bloodcurdling mystery
7. Secret of sandcastle construction could help revive ancient building technique, researchers say
8. New Cellular Bioenergetics Workshops Series Inaugurated by Seahorse Bioscience with Two of the Worlds Leading Bioenergetics Researchers
9. Sandia researchers construct carbon nanotube device that can detect colors of the rainbow
10. Researchers develop new way to see single RNA molecules inside living cells
11. Researchers peer into nanowires to measure dopant properties
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/1/2015)... and SOUTH SAN FRANCISCO, Calif. ... the venture arm of Baxter International Inc. (NYSE: ... LLC ("VPD") today announced the formation of Vitesse Biologics, ... by Baxter Ventures to focus on the development of ... hematology, and oncology. Following the spin-off of Baxter BioScience ...
(Date:6/1/2015)... /CNW/ - Resverlogix Corp. (TSX: RVX) (the "Company") today ... the ERA-EDTA Congress in London, England ... First-in-Class Epigenetic BET-Inhibitor, on Key Renal Parameters in Subjects ... (CKD); a Post-hoc Analysis of Patients from the ASSERT, ... Kam Kalantar-Zadeh , Professor and Chief, Division of Nephrology and Hypertension ...
(Date:6/1/2015)... , June 1, 2015   Epic Sciences, ... develops products and offerings to personalize and advance the ... has expanded the available credit under its existing credit ... amended agreement increases the available capacity of the facility ... the maturity by 27 months to April 1, 2019. ...
(Date:6/1/2015)... , May 29, 2015 Research ... the addition of the "2015 Strategies ... report to their offering. This ... European immunoprotein diagnostic market, including emerging tests, ... strategic profiles of leading suppliers. ...
Breaking Biology Technology:Baxter Ventures, Mayo Clinic And Velocity Pharmaceutical Development Announce The Formation Of Vitesse Biologics, LLC, A Company Structured To Accelerate Therapeutic Innovation 2Baxter Ventures, Mayo Clinic And Velocity Pharmaceutical Development Announce The Formation Of Vitesse Biologics, LLC, A Company Structured To Accelerate Therapeutic Innovation 3Baxter Ventures, Mayo Clinic And Velocity Pharmaceutical Development Announce The Formation Of Vitesse Biologics, LLC, A Company Structured To Accelerate Therapeutic Innovation 4Baxter Ventures, Mayo Clinic And Velocity Pharmaceutical Development Announce The Formation Of Vitesse Biologics, LLC, A Company Structured To Accelerate Therapeutic Innovation 5Resverlogix Presents New Data at 52nd Annual European Renal Association - European Dialysis & Transplant Association Congress (ERA-EDTA) 2Resverlogix Presents New Data at 52nd Annual European Renal Association - European Dialysis & Transplant Association Congress (ERA-EDTA) 3Resverlogix Presents New Data at 52nd Annual European Renal Association - European Dialysis & Transplant Association Congress (ERA-EDTA) 4Epic Sciences Expands Silicon Valley Bank Credit Facility 2Epic Sciences Expands Silicon Valley Bank Credit Facility 3
... Two-dimensional, "sheet-like" nanostructures are commonly employed in biological ... properties have inspired interest in materials such as ... largest two-dimensional polymer crystal self-assembled in water to ... complexity of biological systems with the durable architecture ...
... ... Footprint , ... -- LS9, Inc ., the Renewable Petroleum Company™, today announced that its UltraClean ... was officially registered by the United States Environment Protection Agency (EPA). As a ...
... new method for identifying genetic variation, including mutations, in ... an important research tool that will lead to the ... method, which is directly applicable to cell preparations and ... genetic variation in patient samples from a variety of ...
Cached Biology Technology:Berkeley Lab scientists create 'molecular paper' 2LS9's UltraClean Diesel™ Receives EPA Registration 2Mutations directly identifiable in active genes 2
(Date:4/20/2015)... 2015 Huntington Memorial Hospital is the first ... new miniaturized, wireless monitoring sensor to manage heart failure ... only FDA-approved heart failure monitoring device that has been ... physicians to manage heart failure. The CardioMEMS ... the pulmonary artery (PA) during a non-surgical procedure to ...
(Date:4/14/2015)... 14, 2015  HYPR Corp. today announced it ... ) Alliance tm , an industry consortium transforming ... to share technology and collaborate to deliver open ... more secure and private, and easier to use. ... that protects sensitive user information and eliminates the ...
(Date:4/13/2015)... , April 13, 2015  higi, a leading ... ways to more fully engage with their communities around ... industry-leading, privacy protected and secure API.  ... enables the most accessible, affordable, and convenient vehicle to ... The API will allow ...
Breaking Biology News(10 mins):Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3
... Michigan researchers have discovered how to measure the ... cancer cells, a breakthrough that will revolutionize scientists' ... environment. , A team led by U-M ... multi-walled carbon nanotubes---one of the most promising nanomaterials ...
... Biotechnology, scientists and doctors with the Physicians Committee for ... to grow live cells in the laboratory. At issue ... obtained by puncturing the heart of a fetal calf ... cells in a medium free of animal serum, enabling ...
... have discovered that our ears use the most efficient ... brooks to wailing babies. These results represent a significant ... for transmission to the brain, according to the authors, ... Views" editorial in the Feb. 23 issue of Nature. ...
Cached Biology News:Carbon nanotube absorption measured in worms, cancer cells 2Carnegie Mellon scientists show brain uses optimal code for sound 2Carnegie Mellon scientists show brain uses optimal code for sound 3
Buffer used for mitocapture assays....
... CyScribe GFX Purification Kit, 25 ... CyDye labeled cDNA probesProvides efficient removal ... from labeling reactions with superior yields ... for the purification of cDNA labeled ...
Propidium Iodide: {3,8-diamino-5-[3-(diethylmethylammonio)propyl]-6-phenylphenanthridinium diodide}. Antifade Solution: p-Phenylenediamine and glycerol in PBS solution. 2.5ug/mL Propidium Iodide (PI)...
Detects activated caspases in living cells. Simple/sensitive/straight-forward procedure takes only 30 minutes. Results can be analyzed by flow cytometry/fluorescence microscopy/fluorescence plate rea...
Biology Products: