Navigation Links
UCLA scientists discover new way to wake up the immune system using nano vaults to deliver drugs
Date:5/3/2011

y a gene that caused the cells to secrete CCL21 and then injected into the patient's tumor using guided imaging.

"We thought if we could replace the dendritic cells with a nano-vehicle to deliver the CCL21, we would have an easier and less expensive treatment that also could be used at institutions that don't have GMP," Dubinett said.

If successful, the vault delivery method would add a desperately needed weapon to the arsenal in the fight against lung cancer, which accounts for nearly one-third of all cancer deaths in the United States and kills one million people worldwide every year.

"It's crucial that we find new and more effective therapies to fight this deadly disease," Dubinett said. "Right now we don't have adequate options for therapies for advanced lung cancer."

The vault nanoparticles containing the CCL21 have been engineered to slowly release the protein into the tumor over time, producing an enduring immune response. Although the vaults protect the packed CCL21, they act like a time-release capsule, Rome said.

Rome, Dubinett and Sharma plan to test the vault delivery method in human studies within the next three years and hope the promising results found in the pre-clinical animal tumor models will be replicated. If such a study is approved, it would be the first time a vault nanoparticle is used in humans for a cancer immunotherapy.

The vault nanoparticle would require only a single injection into the tumor because of the slow-release design, and it eventually could be designed to be patient specific by adding the individual's tumor antigens into the vault, Dubinett said. The vaults may also be targeted by adding antibodies to their surface that recognize receptors on the tumor. The injection could then be delivered into the blood stream and the vault would navigate to the tumor, a less invasive process that would be easier on the patients. The vault could also seek out and target tumors and
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles Health Sciences
Source:Eurekalert

Page: 1 2 3 4

Related biology technology :

1. March of Dimes Awards $250,000 Prize to Scientists Who Explained Human Sex Chromosomes
2. UMD scientists make magnetic new graphene discovery
3. NRL scientists demonstrate novel ionic liquid batteries
4. Scientists recreate brain cells from skin cells to study schizophrenia safely
5. Online Career Service for Postgraduate Life Scientists Expands Membership to Individuals
6. Brain scientists offer medical educators tips on the neurobiology of learning
7. Berkeley Lab scientists control light scattering in graphene
8. Now, the story can be told how scientists helped ID Amerithrax
9. Laboratory-grown urethras implanted in patients, scientists report
10. Cellular Dynamics International Scientists Report on Efficient Method to Produce Footprint-Free Induced Pluripotent Stem Cells (iPSCs) Under Feeder-Free Conditions
11. Scientists from Toronto and Helsinki discover genetic abnormalities after creation of stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2015)... , May 20, 2015 Research and Markets ... of the "Top Technologies in HW_Technical Insights" ... of this report evaluated technology trends in the Health ... that are likely to have an impact in the ... analysis of the top 10 health and wellness technologies ...
(Date:5/20/2015)... May 20, 2015  Select Medical Corporation ("Select") ... Trade Commission granted early termination of the waiting ... of 1976, as amended, applicable to the acquisition ... a joint venture that Select has created with ... As previously announced, MJ Acquisition Corporation has signed ...
(Date:5/20/2015)... Agricultural firm H.J. Baker & Bro., Inc. ... Tiger-Sul. Since the purchase of Tiger Industries and ... 2005, H.J. Baker has leveraged the innovation of the ... portfolio of product offerings and solutions expertise. The deal ... innovation of Tiger-Sul, transforming the company into a leading ...
(Date:5/20/2015)... 2015  Cypher Genomics, Inc., a leading genome ... Corporation to apply Cypher,s Coral TM technology ... patient response to innovative medicines. The information generated ... patient access to the right medicine at the ... development and potentially inform new companion diagnostics.  ...
Breaking Biology Technology:Top Technologies in the Health and Wellness Industry 2015 2Select Medical Corporation's Proposed Acquisition of Concentra Inc. through Joint Venture with Welsh Carson Receives Antitrust Clearance 2Agricultural Firm H.J. Baker & Bro., Inc., Celebrates 10 Years Since Acquisition Of Tiger-Sul 2Agricultural Firm H.J. Baker & Bro., Inc., Celebrates 10 Years Since Acquisition Of Tiger-Sul 3Cypher Genomics Collaborates with Celgene Corporation to Identify Novel Genomic Biomarkers 2
... LONDON, November 18 , - New ... - An Estimated Two Billion Work Hours Lost Each Week , ... time that,people between the ages of 40 to 65 are emerging as the ... the,report uncovers a new, younger majority of COPD patients(1) who are in the,prime ...
... ... at the 9th DIA Conference for Contemporary Pharmacovigilance and Risk Management Strategies, which takes place ... of the Integrated Summary of Safety. , ... Emeryville, CA (PRWEB) November 18, 2009 -- BioSoteria, Inc., a drug safety service ...
... Then it was the cylindrically shaped nanotubes. Now, the ... a remarkably flat molecule made of carbon atoms ... Not only is this the thinnest material ... steel and it conducts electricity better than any other ...
Cached Biology Technology:Mainstay of the Global Workforce - 40-65 Year Olds - Hit Hardest by Chronic Obstructive Pulmonary Disease (COPD) 2Mainstay of the Global Workforce - 40-65 Year Olds - Hit Hardest by Chronic Obstructive Pulmonary Disease (COPD) 3Mainstay of the Global Workforce - 40-65 Year Olds - Hit Hardest by Chronic Obstructive Pulmonary Disease (COPD) 4BioSoteria CEO to Present at Drug Safety Conference 2New study confirms exotic electric properties of graphene 2New study confirms exotic electric properties of graphene 3
(Date:5/11/2015)... SAN JOSE, Calif. , May 11, 2015 ... leading developer of human interface solutions, today announced ... Senior Vice President and Chief Financial Officer, reporting ... Mr. Ali replaces Synaptics, current Chief Financial Officer, ... in December 2014. Mr. Ali ...
(Date:5/8/2015)... Calif. , May 8, 2015 Synaptics Inc. ... solutions, today announced that members of the executive management team ... Morgan 43rd Annual Technology, Media and Telecom Conference Date: ... Hotel in Boston, MA ... 27, 2015 Time: 2:45pm ET Location: The New York Palace ...
(Date:4/27/2015)... April 27, 2015  For more than four decades, ... has been the premier worldwide event for the unmanned ... a must-attend event for any local, national, or trade ... emerging commercial markets and current applications of unmanned technologies. ... this projected $48 billion industry, and how it will ...
Breaking Biology News(10 mins):Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2Synaptics to Present at Upcoming Investor Conferences 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5
... out to be just as important as what they eat, according ... The study, led by Dr. Nav Persaud, a family physician, found ... three to five and their levels of non-HDL or "bad" ... life. The paper appeared online in the Canadian Medical ...
... Vitamin D supplementation may help delay early onset of puberty ... presented Monday at The Endocrine Society,s 95th Annual Meeting in ... ages of 10 and 14. Boys undergo these changes later, ... is diagnosed in girls when sexual development begins before the ...
... declining worldwide and a major cause is a deadly fungus ... shows they can also die from this pathogen, contrary to ... spreads the disease. When researchers raised the frogs from ... strain of this pathogen, Batrachochytrium dendrobatidis , also called ...
Cached Biology News:Poor eating behaviors may put preschoolers at risk for later health problems 2Vitamin D supplementation may delay precocious puberty in girls 2Bullfrogs may help spread deadly amphibian fungus, but also die from it 2
... separations of DNA larger than 2, ... megabase pairs. This agarose has the highest gel strength of any electrophoresis agarose ... preparation ... ...
... System is a high-sensitivity peroxidase and ... kit is intended for use in ... two different antigens within the same ... diluted rabbit and mouse primary antibodies. ...
Liquid. PBS containing 10 mM NaN 3 . AVOID FREEZE/THAW CYCLES. Recognizes α1, 2, 3, 5, 6 and 7 subunits of 20S proteasome. ...
AVOID FREEZE/THAW CYCLES. Recognizes the UCP-2 protein....
Biology Products: