Navigation Links
UCLA scientists discover new way to wake up the immune system using nano vaults to deliver drugs
Date:5/3/2011

UCLA scientists have discovered a way to wake up the immune system to fight cancer by delivering an immune system-stimulating protein in a nanoscale container called a vault directly into lung cancer tumors, harnessing the body's natural defenses to fight disease growth.

The vaults, barrel-shaped nanoscale capsules found in the cytoplasm of all mammalian cells, were engineered to slowly release a protein, the chemokine CCL21, into the tumor. Pre-clinical studies in mice with lung cancer showed that the protein stimulated the immune system to recognize and attack the cancer cells, potently inhibiting cancer growth, said Leonard Rome, a researcher at UCLA's Jonsson Comprehensive Cancer Center, associate director of the California NanoSystems Institutes and co-senior author of the study.

"Researchers have been working for many years to develop effective immune therapies to treat cancer, with limited success," said Rome, who has been studying vaults for decades. "In lung tumors, the immune system is down-regulated and what we wanted to do was wake it up, find a way to have the cancer say to the immune system, 'Hey, I'm a tumor and I'm over here. Come get me.' "

The study appears in the May 3, 2011 issue of PLoS One, a peer-reviewed journal of the Public Library of Science.

The new vault delivery system, which Rome characterized as "just a dream" three years ago, is based on a 10-year, on-going research effort focusing on using a patient's white blood cells to create dendritic cells, cells of the immune system that process antigen material and present it on the surface to other immune system cells. A Phase I study that is part of the effort, led by ULCA's Dr. Steven Dubinett, used a replication-deficient adenovirus to infect the dendritic cells and prompt them to over-secrete CCL21, the first time the chemokine has been administered to humans. The engineered cells 10 million at a time were then injected directly int
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles Health Sciences
Source:Eurekalert

Page: 1 2 3 4

Related biology technology :

1. March of Dimes Awards $250,000 Prize to Scientists Who Explained Human Sex Chromosomes
2. UMD scientists make magnetic new graphene discovery
3. NRL scientists demonstrate novel ionic liquid batteries
4. Scientists recreate brain cells from skin cells to study schizophrenia safely
5. Online Career Service for Postgraduate Life Scientists Expands Membership to Individuals
6. Brain scientists offer medical educators tips on the neurobiology of learning
7. Berkeley Lab scientists control light scattering in graphene
8. Now, the story can be told how scientists helped ID Amerithrax
9. Laboratory-grown urethras implanted in patients, scientists report
10. Cellular Dynamics International Scientists Report on Efficient Method to Produce Footprint-Free Induced Pluripotent Stem Cells (iPSCs) Under Feeder-Free Conditions
11. Scientists from Toronto and Helsinki discover genetic abnormalities after creation of stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2015)... ... 27, 2015 , ... The Kansas City Animal Health Investment ... health companies to hear from animal health companies with the newest technology. Companies ... agreements or distribution contracts. This meeting is one of the only investment ...
(Date:8/27/2015)... , Aug. 27, 2015 /PRNewswire/ - Portage ... Exchange: PBT.U), and Biohaven Pharmaceutical Holding Company Limited ... a Phase I study of BHV-0223, a glutamate ... (IND) regarding BHV-0223 and recently obtained clearance from ... proceed with human testing. Portage holds 54% equity ...
(Date:8/27/2015)... GUELPH, ON , Aug. 27, 2015 /PRNewswire/ - BIOREM Inc. ... the three and six-month periods ended June 30, 2015. Biorem,s complete ... ( www.sedar.com ). FINANCIAL HIGHLIGHTS: in ,000,s except earnings per ... , 2014 , 2015 , ... 9,398 , 4,433 Gross profit , 1,656 ...
(Date:8/27/2015)... Boston, MA (PRWEB) , ... August 27, 2015 , ... ... the United States, ranking iLab Solutions as number 1,361 in growth for the three ... part of the top 0.1% fastest-growing privately held organizations in the country. , ...
Breaking Biology Technology:VetStem Biopharma, Inc. Among Seventeen Companies Selected to Present at the KC Animal Health Investment Forum on September 1st 2015 2VetStem Biopharma, Inc. Among Seventeen Companies Selected to Present at the KC Animal Health Investment Forum on September 1st 2015 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 4BIOREM Reports $718,000 Net Earnings for the Second Quarter 2BIOREM Reports $718,000 Net Earnings for the Second Quarter 3iLab Solutions Named to 2015 Inc. 5000 List 2iLab Solutions Named to 2015 Inc. 5000 List 3
... Jennerex, Inc. (San Francisco, CA,and Ottawa, Canada) a ... Reviews Cancer, has published an article about,the company,s ... encouraging clinical and preclinical data. The article,published ... David H. Kirn, M.D.,president and chief executive officer ...
... Will Continue to Fuel Growth and Generate CashNEW YORK, Feb. ... President James C. Borel said today he expects DuPont business ... by at least 1 to 2 points in 2009 and ... Agriculture & Nutrition segment an average of at least 15 ...
... 10 , - Nerviano ... the CDC7,Inhibitor , Nerviano Medical ... to conduct for the first time clinical trials of ... that is responsible for,the uncontrolled proliferation of cancer cells. ...
Cached Biology Technology:Nature Reviews Publishes Article About Jennerex's Multi-Mechanistic Cancer Therapeutic 2Nature Reviews Publishes Article About Jennerex's Multi-Mechanistic Cancer Therapeutic 3DuPont Expects Increased Global Seed Corn Share, Continued Agriculture Earnings Growth 2DuPont Expects Increased Global Seed Corn Share, Continued Agriculture Earnings Growth 3DuPont Expects Increased Global Seed Corn Share, Continued Agriculture Earnings Growth 4DuPont Expects Increased Global Seed Corn Share, Continued Agriculture Earnings Growth 5FDA Approves Clinical Studies of a Novel Anti-Cancer Drug Developed by Italian Researchers 2
(Date:8/12/2015)... Aug. 12, 2015  New research unveiled at ... Android phones to steal users, fingerprints. Information released ... of fingerprint scanners on mobile devices, making the ... secure biometrics on mobile devices, HYPR Corp. recently ... convenient authentication systems with strong cryptographic security. More ...
(Date:8/10/2015)... LONDON , August 10, 2015 ... visiongain offers comprehensive analysis of the global border ... will generate revenues of $16.4bn in 2015. Now: ... This is an example of the business critical issue you ... to read visiongain ,s objective analysis of how this ...
(Date:8/5/2015)... 2015 According to a new ... Software, Services, Vertical (BFSI, Airport, IT & Telecom, Utilities, ... Forecast to 2020", published by MarketsandMarkets, defines and segments ... various segments. The global PIAM Market is estimated to ... by 2019, at a CAGR of 14.9 % from ...
Breaking Biology News(10 mins):HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 3Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 2Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 3Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 4Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 5Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 6Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 7Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 8Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 9Physical Identity and Access Management Market Worth $546.2 Million by 2019 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 4
... the Andes mountains of Ecuador have described a new plant ... itself a mini biodiversity hotspot. The new species, Piper ... insect species, most of which are entirely dependent on this ... larger project which focuses on the influence of plant-produced chemical ...
... factory built of gel does not sound very durable. But ... University do not have to last. They will actually ... medicine is required and they will gradually dissolve and ... The prospects are so enormous that Associate Professor of ...
... that generates the most scientific debate is the dating of ... the Spanish National Research Centre for Human Evolution, among others, ... , Journal of Archaeological Science , has clarified that the ... Homo antecessor were discovered in 1994, is 900,000 years ...
Cached Biology News:New plant species a microcosm of biodiversity 2Tiny soft medicine factories 2Dating is refined for the Atapuerca site where Homo antecessor appeared 2