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UCLA researchers' smartphone 'microscope' can detect a single virus, nanoparticles
Date:9/17/2013

Your smartphone now can see what the naked eye cannot: A single virus and bits of material less than one-thousandth of the width of a human hair.

Aydogan Ozcan, a professor of electrical engineering and bioengineering at the UCLA Henry Samueli School of Engineering and Applied Science, and his team have created a portable smartphone attachment that can be used to perform sophisticated field testing to detect viruses and bacteria without the need for bulky and expensive microscopes and lab equipment. The device weighs less than half a pound.

"This cellphone-based imaging platform could be used for specific and sensitive detection of sub-wavelength objects, including bacteria and viruses and therefore could enable the practice of nanotechnology and biomedical testing in field settings and even in remote and resource-limited environments," Ozcan said. "These results also constitute the first time that single nanoparticles and viruses have been detected using a cellphone-based, field-portable imaging system."

The new research, published on Sept. 9 in the American Chemical Society's journal ACS Nano, comes on the heels of Ozcan's other recent inventions, including a cellphone cameraenabled sensor for allergens in food products and a smart phone attachment that can conduct common kidney tests.

Capturing clear images of objects as tiny as a single virus or a nanoparticle is difficult because the optical signal strength and contrast are very low for objects that are smaller than the wavelength of light.

In the ACS Nano paper, Ozcan details a fluorescent microscope device fabricated by a 3-D printer that contains a color filter, an external lens and a laser diode. The diode illuminates fluid or solid samples at a steep angle of roughly 75 degrees. This oblique illumination avoids detection of scattered light that would otherwise interfere with the intended fluorescent image.

Using this device,
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Contact: Bill Kisliuk
bkisliuk@support.ucla.edu
310-206-0540
University of California - Los Angeles
Source:Eurekalert

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