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UCF team developing tool kit to help diagnose dementia
Date:9/29/2009

s.

Cho has previously developed a microfluidic mixer and a miniaturized electrochemical sensor for "lab on a chip" applications that would allow scientists to perform multiple analyses on one miniaturized chip. He said the ROS assessment tool will be developed on a similar platform.

What will make the ROS detector unique is the use of nanoparticles to help detect the high oxidative stress that has been identified as one of the earliest indicators of Alzheimer's and Parkinson's diseases.

Cho partnered with Sudipta Seal, director of UCF's NanoScience Technology and Advanced Materials Processing and Analysis centers, who has studied rare earth cerium oxide nanoparticles for years. Seal has found them to be effective at everything from treating glaucoma to cleansing fly ash from smokestacks.

Because the nanoparticles behave like an antioxidant, protecting cells from oxidative stress, they can effectively serve as an indicator of ROS, Seal said.

Together with Diego Diaz, a NanoScience Technology Center and Department of Chemistry faculty member, the researchers are collaborating with a group led by Lee Goldstein, an associate professor at the Boston University School of Medicine.

UCF's share of the NSF funding is $346,000.


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Contact: Zenaida Gonzalez Kotala
zkotala@mail.ucf.edu
407-823-6120
University of Central Florida
Source:Eurekalert  

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