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U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) as the First Medication for Add-On Treatment of Major Depressive Disorder (MDD)

cts, with a focus on pharmaceutical products for the treatment of diseases and consumer products for the maintenance of everyday health. Otsuka is committed to being a corporation that creates global value, adhering to the high ethical standards required of a company involved in human health and life, maintaining a dynamic corporate culture, and working in harmony with local communities and the natural environment. The Otsuka Pharmaceutical Group comprises 99 companies and employs approximately 31,000 people in 17 countries and regions worldwide. Otsuka and its consolidated subsidiaries earned U.S. $7.2 billion in annual revenues in fiscal 2006.

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* Inadequate response for prospective treatment was defined as less than

50 percent improvement on the 17-item version of the Hamilton Depression

Rating Scale (HAMD17), minimal HAMD17 score of 14, and a Clinical Global

Impressions Improvement rating of no better than minimal improvement.


(1) Rush AJ, Trivedi MH, Wisniewski SR, et al. Acute and Longer-Term

Outcomes in Depressed Outpatients Requiring One or Several Treatment

Steps: A STAR*D Report. Am J Psych. 2006;163:1905-1917.

(2) Kessler RC, Berglund P, Demler O, et al. The epidemiology of major

depressive disorder: results from the national comorbidity survey

replication (NCS-R). JAMA. June 18 2003;289(23):3095-3105.


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