Navigation Links
U Alberta finds weakness in armor of killer hospital bacteria
Date:6/8/2012

There's new hope for development of an antibiotic that can put down a lethal bacteria or superbug linked to the deaths of hundreds of hospital patients around the world.

Researchers from the University of Alberta-based Alberta Glycomics Centre found a chink in the molecular armour of the pathogen Acinetobacter baumannii. The bacteria first appeared in the 1970's and in the last decade it developed a resistance to most antibiotics.

U of A microbiologist Mario Feldman identified a mechanism that allows Acinetobacter baumannii to cover its surface with molecules knows as glycoproteins.

Feldman and his team then discovered that if the superbug cannot produce glycoproteins they become less virulent and less capable of forming biofilms, which protect the bacteria from antibiotics.

Feldman says more work is required to understand how the bacteria produces glycoproteins. The researchers say that will enable future development of drugs to interrupt the production of glycoproteins, reducing the bacteria's ability to shield it from antibiotics.

Acinetobacter baumannii is a particularly insidious and contagious pathogenic bacteria that has plagued hospitals around the world. It spreads from one person to another by physical contact. The bacteria can live on hard surfaces for several days and can cling to hospital equipment like catheter tubes and inhalers. Acinetobacter baumannii is also spread by coughing and sneezing.

Hospital patients whose immune systems are already worn down are the most susceptible to Acinetobacter baumannii. It infects wounds and can spread to the lungs, blood and brain.

Feldman is a principal investigator for the Alberta Glycomics Centre at the U of A. He was assisted by U of A graduate students Jeremy Iwashkiw and Brent Weber along with research colleagues in Ottawa, Austria and Australia. Their work was published June 7 in the journal PLoS Pathoge
'/>"/>

Contact: Brian Murphy
brian.murphy@ualberta.ca
780-492-6041
University of Alberta
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Study finds chronic abnormal brain blood flow in Gulf War veterans
2. New Competitive Arena Emerges for Pharmaceutical Companies in Healthcares Changing Payment Landscape, Finds PwC Health Research Institute Study
3. Study In Prenatal Diagnosis Finds Sequenom CMMs MaterniT21™ PLUS Lab-developed Test Accurately Detects Fetal Trisomies In Pregnant Women Carrying Twins Or Triplets
4. Armored caterpillar could inspire new body armor
5. NTU scientists invent superbug killers
6. BBVA Foundation Unites the Efforts of Massachusetts General Hospital and Barcelonas Vall dHebron Hospital in Biomarker Research for Personalized Cancer Therapies
7. Antelope Valley Hospital Converts to Masimo rainbow SET for State-of-the-Art Noninvasive Patient Monitoring Capabilities
8. What Hospitals Must Do to Thrive -- Not Just Survive -- on Medicare Margins
9. Meaningful Use Stage Two: The Advisory Board Company Helps Hospitals Set Strategy
10. Biotech Firm Spun Off from Childrens Hospital Raises $7 Million to Advance Magnetic-Based Vascular Treatment
11. Narayana Hrudayalaya Hospitals Teams With Ascension Health Alliance to Build Health City at Grand Cayman
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... -- According to a new market research ... Electrophoresis, Agarose & Polyacrylamide Gel, Capillary Electrophoresis, Isoelectric Focusing, ... by End User - Global Forecast to 2020", published ... around $1.98 Billion by 2020 with a CAGR of ... Browse 226 ma rket data T ...
(Date:5/21/2015)... 2015 /PRNewswire/ - SQI Diagnostics Inc. ("SQI" or the ... develops and commercializes proprietary technologies and products for advanced ... for the second fiscal quarter ended March 31, 2015. ... to advance business with our existing customers and to ... and CEO of SQI. "The delivery of a fully ...
(Date:5/21/2015)... NEW YORK , May 21, 2015  Prima ... biotechnology company that is striving to become a leader ... of cancer, recently announced that the final CVac data ... has shown a clear trend for a clinically meaningful ... ("SOC") in second remission patients. In the ...
(Date:5/21/2015)... 21, 2015 W. R. Grace ... facility in Worms, Germany has received good manufacturing ... of the International Pharmaceutical Excipient Council (IPEC) Foundation. ... produce its SYLOID® FP brand of pharmaceutical grade ... following the Curtis Bay, Maryland (USA) and Sorocaba, ...
Breaking Biology Technology:Electrophoresis Market Worth $1.98 Billion by 2020 2Electrophoresis Market Worth $1.98 Billion by 2020 3Electrophoresis Market Worth $1.98 Billion by 2020 4SQI Diagnostics Reports Second Quarter Financial Results 2SQI Diagnostics Reports Second Quarter Financial Results 3SQI Diagnostics Reports Second Quarter Financial Results 4SQI Diagnostics Reports Second Quarter Financial Results 5SQI Diagnostics Reports Second Quarter Financial Results 6SQI Diagnostics Reports Second Quarter Financial Results 7SQI Diagnostics Reports Second Quarter Financial Results 8Correction Continues after Big Move - BrokerBank Securities, Inc. 2Grace European Facility Receives GMP Excipient Certification for SYLOID® FP Silica Gel 2
... have issued a warning that it is too early ... Published on Friday in the journal Science, signatories include ... Netherlands, India, Germany and the UK. The UK is ... East Anglia and Dr Richard Lampitt of Southampton Universitys ...
... BIRMINGHAM, Ala., Jan. 10 BioCryst,Pharmaceuticals, Inc. (Nasdaq: ... M.D.,has joined BioCryst as a consultant and interim ... years of expertise in global pharmaceutical,development to his ... ), "We are very pleased to have ...
... Ky., and Newport News, Va. Also ... ... excellence and remarkable achievements in its,community, Harborview Medical Center of Seattle is ... of the most esteemed,honors of excellence in community service in healthcare. As ...
Cached Biology Technology:BioCryst Strengthens Its Expertise in Clinical Development By Adding Thomas J. Simon, M.D. as Interim Chief Medical Officer To Meet Growing Product Development and Commercial Opportunities 2BioCryst Strengthens Its Expertise in Clinical Development By Adding Thomas J. Simon, M.D. as Interim Chief Medical Officer To Meet Growing Product Development and Commercial Opportunities 3BioCryst Strengthens Its Expertise in Clinical Development By Adding Thomas J. Simon, M.D. as Interim Chief Medical Officer To Meet Growing Product Development and Commercial Opportunities 4Harborview Medical Center in Seattle Receives Prestigious $100,000 Foster G. McGaw Prize for Excellence in Community Service 2Harborview Medical Center in Seattle Receives Prestigious $100,000 Foster G. McGaw Prize for Excellence in Community Service 3Harborview Medical Center in Seattle Receives Prestigious $100,000 Foster G. McGaw Prize for Excellence in Community Service 4Harborview Medical Center in Seattle Receives Prestigious $100,000 Foster G. McGaw Prize for Excellence in Community Service 5Harborview Medical Center in Seattle Receives Prestigious $100,000 Foster G. McGaw Prize for Excellence in Community Service 6
(Date:5/18/2015)... , May 18, 2015 Fingerprint Cards ... FPC1020, FPC1025, FPC1145, FPC1155 and FPC1035 from one if its ... until and including Q3 2015 and the sensors will be ... Communicated order values for 2015 hereby amount to 740 MSEK ... 2015 of 140 MSEK and a number of smaller orders ...
(Date:5/14/2015)... 14, 2015  Verificient Technologies, Inc., a ... online remote proctoring, announced a new alliance ... and creator of the Canvas Learning Management ... companies will benefit from the seamless integration ... As a fully integrated multifactor biometrics behavioral ...
(Date:5/11/2015)...  Through a well-rounded UAS delegation representing private industry, government, ... showing at AUVSI,s Unmanned 2015 conference last week in ... UAS industry met with over 200 hundred people ... the UAS ecosystem. "Our message is clear ... Aerospace Rich Knoll . "If you want to fly ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Verificient and Instructure Announce Alliance Partnership to Provide Online Proctoring for K-12 and Higher Education Institutions 2Ohio Flies High at Unmanned '15, Sets Stage for Ohio UAS Conference 2
... had sex in over 40 million years of existence ... new research published today. The study challenges the assumption ... provides scientists with new insight into why species evolve ... in PLoS Biology, focuses on the study of bdelloid ...
... Borstel, cancer is a metaphorical example of the perfect invasion ... landed on a deserted island in the Galapagos Archipelago, the ... many mutations through many generations to establish itself as an ... is there, like any newly stabilized species in different ecological ...
... cancer cells from being forced to devour themselves, removing ... growth, researchers at The University of Texas M. D. ... Molecular Cancer Research. , The protein tissue transglutaminase, known ... researchers at M. D. Anderson and elsewhere to be ...
Cached Biology News:No sex for 40 million years? No problem 2New bird, bat species revealed by extensive DNA barcode studies 2Protein found to shield pancreatic cancer cells from self-destruction 2
... The BioPrime Plus Array CGH Genomic Labeling ... enable reproducible labeling of genomic DNA samples ... in both indirect and direct labeling formats, ... Systems provide a flexible solution to your ...
The Cellject Elecroporator is suitable for all cell types including embryo, mammalian, plant, yeast and bacterial. Its has highly user-freindly programing and can be used remotely, for example in a l...
Maxi XL Hybridization Oven for Extra Large bottles. 6 bottle (70 mm) rotisserie + shaker tray available for simultaneous use. Includes linear and orbital shaker trays, 4 extra large bottles, pack o...
Shake 'n' Stack Oven - New Model (includes 10 bottle capacity rotisserie, adjustable feet, drip tray, manual PLUS Shaker Platform)...
Biology Products: