Navigation Links
U Alberta finds weakness in armor of killer hospital bacteria
Date:6/8/2012

There's new hope for development of an antibiotic that can put down a lethal bacteria or superbug linked to the deaths of hundreds of hospital patients around the world.

Researchers from the University of Alberta-based Alberta Glycomics Centre found a chink in the molecular armour of the pathogen Acinetobacter baumannii. The bacteria first appeared in the 1970's and in the last decade it developed a resistance to most antibiotics.

U of A microbiologist Mario Feldman identified a mechanism that allows Acinetobacter baumannii to cover its surface with molecules knows as glycoproteins.

Feldman and his team then discovered that if the superbug cannot produce glycoproteins they become less virulent and less capable of forming biofilms, which protect the bacteria from antibiotics.

Feldman says more work is required to understand how the bacteria produces glycoproteins. The researchers say that will enable future development of drugs to interrupt the production of glycoproteins, reducing the bacteria's ability to shield it from antibiotics.

Acinetobacter baumannii is a particularly insidious and contagious pathogenic bacteria that has plagued hospitals around the world. It spreads from one person to another by physical contact. The bacteria can live on hard surfaces for several days and can cling to hospital equipment like catheter tubes and inhalers. Acinetobacter baumannii is also spread by coughing and sneezing.

Hospital patients whose immune systems are already worn down are the most susceptible to Acinetobacter baumannii. It infects wounds and can spread to the lungs, blood and brain.

Feldman is a principal investigator for the Alberta Glycomics Centre at the U of A. He was assisted by U of A graduate students Jeremy Iwashkiw and Brent Weber along with research colleagues in Ottawa, Austria and Australia. Their work was published June 7 in the journal PLoS Pathoge
'/>"/>

Contact: Brian Murphy
brian.murphy@ualberta.ca
780-492-6041
University of Alberta
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Study finds chronic abnormal brain blood flow in Gulf War veterans
2. New Competitive Arena Emerges for Pharmaceutical Companies in Healthcares Changing Payment Landscape, Finds PwC Health Research Institute Study
3. Study In Prenatal Diagnosis Finds Sequenom CMMs MaterniT21™ PLUS Lab-developed Test Accurately Detects Fetal Trisomies In Pregnant Women Carrying Twins Or Triplets
4. Armored caterpillar could inspire new body armor
5. NTU scientists invent superbug killers
6. BBVA Foundation Unites the Efforts of Massachusetts General Hospital and Barcelonas Vall dHebron Hospital in Biomarker Research for Personalized Cancer Therapies
7. Antelope Valley Hospital Converts to Masimo rainbow SET for State-of-the-Art Noninvasive Patient Monitoring Capabilities
8. What Hospitals Must Do to Thrive -- Not Just Survive -- on Medicare Margins
9. Meaningful Use Stage Two: The Advisory Board Company Helps Hospitals Set Strategy
10. Biotech Firm Spun Off from Childrens Hospital Raises $7 Million to Advance Magnetic-Based Vascular Treatment
11. Narayana Hrudayalaya Hospitals Teams With Ascension Health Alliance to Build Health City at Grand Cayman
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... Bioptigen announced today the availability ... the optical device metrology and pre-clinical ophthalmic research markets. ... for Contact Lens Metrology is designed for non-destructive, non-contact, ... lens, IOL structures, and donor tissues. The ... immersed in a hydration bath (saline), automated segmentation of ...
(Date:9/15/2014)... -- iVinci Health LLC, the company behind the healthcare industry,s ... as VisitPay®, has successfully closed $5 million in new ... new extension to VisitPay® – an online Payment and ... for patients to manage their medical bills and set-up ... families. The new round of funding, which ...
(Date:9/15/2014)... AUSTIN, Texas , Sept. 15, 2014 The ... changes in climate, says a new article published by the ... Ahmed , PhD, on climate change and its effects on ... part of an extensive study conducted by Dr. Ahmed in ... China and has implications for the future ...
(Date:9/15/2014)... 15. September 2014 Die zweite jährliche ... vom 12. bis 18. Oktober stattfinden. Die IPAW ... Therapeutics Association (PPTA) und ihrer Mitgliedsunternehmen ... Das globale Bewusstsein für die Gewinnung von Quellplasma ... beim Retten und Verbessern von Leben zu würdigen ...
Breaking Biology Technology:Bioptigen Introduces Deep Imaging OCT System for Contact Lens Metrology 2iVinci Health Raises $5M to Fuel National Expansion, Announces Launch of Personal Finance Portal for Healthcare 2iVinci Health Raises $5M to Fuel National Expansion, Announces Launch of Personal Finance Portal for Healthcare 3Tea Taste and Quality Affected by Climate Change 2Tea Taste and Quality Affected by Climate Change 3Tea Taste and Quality Affected by Climate Change 4International Plasma Awareness Week feiert Spender und rückt seltene Krankheiten in den Mittelpunkt 2International Plasma Awareness Week feiert Spender und rückt seltene Krankheiten in den Mittelpunkt 3
... for Nanotechnology (LCN) have discovered electronic stripes, called ,charge ... that make up a graphitic superconductor. This is the ... and the finding is likely to have profound implications ... scientists believe will play a key role in the ...
... Inc. (NYSE: WPI ) today announced that ... the United States Food and Drug Administration for its ... and 0.02 mg ethinyl estradiol), a generic version of ... in patent litigation with Bayer concerning this product.  ...
... HAYWARD, Calif., Nov. 29, 2011 Metabolex, Inc., ... development of proprietary new medicines for the treatment ... has been recognized in Windhover,s "Top 10 most ... a potential best-in-class treatment for gout that not ...
Cached Biology Technology:Graphene earns its stripes 2Watson's Generic Yaz(R) Receives FDA Approval 2Metabolex Gout Program Recognized in Windhover's Top 10 Most Interesting Projects to Watch 2Metabolex Gout Program Recognized in Windhover's Top 10 Most Interesting Projects to Watch 3
(Date:9/15/2014)... produced naturally across all kingdoms of life and constitute ... range of biological activities. The presence of halogen substituents ... their molecular properties. , One of the ... the late-stage, site-specific incorporation of a halogen atom into ... bond (one of the most inert chemical bonds known ...
(Date:9/15/2014)... new strategic vision document, released today by the ... the long-term goals, objectives, and strategies for the ... over the next five years (2015-2020). In ... activities, to be funded in 2015, will include ... fellowships. , The $500 million, 30-year program ...
(Date:9/15/2014)... that affect hearing and cognitive function may play roles ... and perceive rhythm, pitch, timbre, tone durations, and formal ... BioEssays article explain that extremes in musical aptitude ... the majority of individuals having moderate aptitude. , "This ... to several underlying genes, and it is influenced to ...
Breaking Biology News(10 mins):Pitt chemical biologist finds new halogenation enzyme 2NAS Gulf Research Program announces strategic vision, initial opportunities 2NAS Gulf Research Program announces strategic vision, initial opportunities 3NAS Gulf Research Program announces strategic vision, initial opportunities 4
... propose ever-larger conservation areas in the tropics, ones that ... banding together with their community leaders who ultimately determine ... parts of the world., "When people sacrifice to conserve, ... Christie, University of Washington associate professor of marine affairs ...
... Alexandria, Va. The American Association for Dental ... 2010 AADR Neal W. Chilton Fellowship in Clinical Research ... Meeting & Exhibition in Washington, DC, March 3, 2010. ... and associate director of the Delta Dental of Kentucky ...
... the first-ever data to show that the enzyme calcineurin is ... and that loss of the protein leads to heart problems ... in the Journal of Biological Chemistry as the ... research was led by scientists at Cincinnati Children,s Hospital Medical ...
Cached Biology News:Local social dynamics key to success of tropical marine conservation areas 2Scientists identify critical enzyme in healthy heart function 2