Navigation Links
Two-faced miniatures
Date:11/15/2007

This release is available in German.

Many scientists are working feverishly to develop reliable but simple methods for the production of tiny particles with defined size and shape that are covered with special regular patterns in two or three dimensions and at both the nano- and the microscale. These miniature objects have countless applications in modern technology, from diagnostic systems to the generation of artificial tissues to improved data storage. A team headed by Edwin L. Thomas and Patrick S. Doyle at MIT in Cambridge, Massachusetts (USA) has now developed a new method for the large-scale synthesis of three-dimensionally patterned polymer particles with morphological characteristics in the submicrometer range. As described in the journal Angewandte Chemie, with the use of stop-flow interference lithography, the team has even been able to produce Janus particles, microparticles with two chemically different hemispheres.

Our new method is a combination of phase mask interference lithography and mirofluidic flow lithography, unifying the strengths of these two methods, explain the researchers. Liquid precursors of a polymer whose formation is induced by light are introduced into a microfluidic system (a system of channels that are just a few micrometers wide). The bottom portion of the device is a phase mask with a periodic surface structure. This arrangement is irradiated through a transparency mask that defines the shape of the resulting particles. In a test sample these were triangles with sides of 60 m. Once the parallel light rays pass through the strictly periodic surface structure of the phase mask, the result is a complex three-dimensional distribution of light intensity within the liquid (interference). In regions of high intensity, the polymer precursors are cross-linked to form three-dimensional structures in a solid hydrogel. In this way, the researchers were able to give the triangular particles a knobby, lattice-like structure.

Because this method works continuously, it can attain a very high throughput: Liquid flows in and polymerizes to form particles that are immediately rinsed away when the next portion of liquid followsall in less than a second. In contrast to other techniques, the liquid does not need to be deposited in an even layer on a support and developed stepwise.

In addition, within a microchannel, it is possible to allow two different liquids to flow side by side without mixing. If the transparency mask is adjusted so that the light irradiates a region around the boundary between the two liquids, the process results in Janus particles with two chemically different hemispheres.


'/>"/>

Contact: Edwin L. Thomas
elt@mit.edu
617-253-6901
Wiley-Blackwell
Source:Eurekalert

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/30/2016)... /PRNewswire/ -  Equicare Health Inc ., the leading supplier ... one of the top 100 companies in the 2016 ... distinguishes the top digital health companies across the globe. ... this year continually upgrading our product with the ongoing ... team," says Len Grenier , CEO of Equicare ...
(Date:11/30/2016)... , 30. November 2016   Merck ... heute die Unterzeichnung einer Reihe von Vereinbarungen ... wird Evotec AG Screeningleistungen für Mercks Palette ... Der Zugriff auf diese Bibliotheken in Kombination ... einen schnelleren Weg zur Ermittlung und Erforschung ...
(Date:11/30/2016)... ... November 30, 2016 , ... SSCI, the established leader ... the implications of the latest FDA guidance on pharmaceutical cocrystals as drug substance ... Cambridge, MA. , The event follows the successful November 15th event that ...
(Date:11/30/2016)... ... November 30, 2016 , ... On 28 November 2016, ... for four elements: nihonium (Nh), moscovium (Mc), tennessine (Ts), and oganesson (Og), respectively ... review, the names earlier proposed by the discoverers have been approved by the IUPAC ...
Breaking Biology Technology:
(Date:11/24/2016)... Cercacor today introduced Ember TM Sport ... non-invasively measure hemoglobin, Oxygen Content, Oxygen Saturation, Perfusion ... in approximately 30 seconds. Smaller than a smartphone, using ... to key data about their bodies to help monitor ... Hemoglobin carries oxygen to muscles. When hemoglobin ...
(Date:11/19/2016)... 18, 2016 Securus Technologies, a leading provider ... safety, investigation, corrections and monitoring, announced today that it ... to have an independent technology judge determine who has ... high tech/sophisticated telephone calling platform, and the best customer ... do most of what we do – which clearly ...
(Date:11/15/2016)... , Nov. 15, 2016  Synthetic Biologics, ... developing therapeutics focused on the gut microbiome, today ... of 25,000,000 shares of its common stock and ... stock at a price to the public of ... to Synthetic Biologics from the offering, excluding the ...
Breaking Biology News(10 mins):