Navigation Links
Two Pivotal Vectibix® Phase 3 Studies in First and Second-Line Treatment of Metastatic Colorectal Cancer Published in the Journal of Clinical Oncology
Date:10/4/2010

ts whose tumors harbor a mutated KRAS gene, the KRAS protein is always turned "on," regardless of whether the EGFR has been activated or therapeutically inhibited. KRAS mutations occur in approximately 40 – 50 percent of mCRC patients.

About Colorectal CancerColorectal cancer is the fourth most common cancer in men and the third most common cancer in women worldwide. Approximately 1.2 million cases of colorectal cancer are expected to occur globally. With more than 630,000 deaths worldwide per year, it is the third leading cause of cancer-related death in the Western world. The highest incidence rates are found in Japan, North America, parts of Europe, New Zealand, and Australia, and rates are low in Africa and Southeast Asia. Rates are substantially higher in men than in women.

About VectibixVectibix is the first fully human anti-EGFR antibody approved by the United States (U.S.) Food and Drug Administration (FDA) for the treatment of mCRC. Vectibix was approved in the U.S. in September 2006 as a monotherapy for the treatment of patients with EGFR-expressing mCRC after disease progression on or following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens.

The effectiveness of Vectibix as a single agent for the treatment of EGFR-expressing mCRC is based on progression-free survival. Currently no data are available that demonstrate an improvement in disease-related symptoms or increased survival with Vectibix.

Retrospective subset analyses of mCRC trials have not shown a treatment benefit for Vectibix in patients whose tumors had KRAS mutations in codon 12 or 13. Use of Vectibix is not recommended for the treatment of colorectal cancer with these mutations.

In December 2007, the European Medicine Agency (EMA) granted a conditional marketing authorization for Vectibix as a monotherapy for the treatment of patients with EGFR-expressing mCRC with non-mutated (wild-ty
'/>"/>

SOURCE Amgen
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11

Related biology technology :

1. NovaRx Initiates Pivotal Phase III Clinical Trial in Lung Cancer Patients
2. Positive SPA Reply From the FDA for TopoTargets Pivotal Trial With Belinostat in PTCL
3. Fifth DuraHeart(TM) U.S. Implant Marks Important Milestone in U.S. Pivotal Trial
4. Oncolytics Biotech Inc. Announces Decision to Pursue Phase II/III Pivotal Clinical Trial
5. Genmab A/S: Ofatumumab Pivotal CLL Data to be Presented at ASH
6. Enrollment in Delcaths Pivotal Phase III Metastatic Melanoma Clinical Trial Reaches Halfway Point
7. BioSyntech to conclude enrolment for pivotal BST-CarGel(R) trial in February 2009
8. BioSyntech Achieves Enrolment Goal for Pivotal Trial of BST-CarGel(R), its Cartilage Repair Device
9. ExonHit Therapeutics Invested Strongly in 2008 for Pivotal 2009 Results
10. PROVENGE Significantly Prolongs Survival in Men With Advanced Prostate Cancer in Pivotal Phase 3 IMPACT Study
11. BioMS Medicals pivotal international multiple sclerosis trial receives positive review from Data Safety Monitoring Board
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... 2014 This is a professional ... China Isopropanol (IPA) industry. The report provides a ... and industry chain structure. Global market analysis and ... focus on history, developments, trends and competitive landscape ... and Chinese situation is also offered. , The ...
(Date:9/23/2014)... 23, 2014 Equashield ( ...     Devices  (CSTD) for hazardous drugs, ... Medical Technology Corporation.  Equashield,s leading CSTD has been ... , China and ... to expand globally, and throughout the ...
(Date:9/23/2014)... Dr. Williams says, “Find The Black Box ( ... three phase process that can lead to the creation ... go far beyond anything previously imagined. First everyone must ... , “Every effort to improve the quality of healthcare ... throughout that system because all of the experts have ...
(Date:9/23/2014)... , September 23, 2014 ... with funding from Imperial Innovations, Cambridge Innovation Capital and ... a clinical cancer genomics company focused on harnessing ... to improve cancer testing and treatment, today announced ... led by Imperial Innovations and including Cambridge Innovation ...
Breaking Biology Technology:(IPA) Isopropanol Industry International & China Development Trend Analysis Now Available at DeepResearchReports.com 2(IPA) Isopropanol Industry International & China Development Trend Analysis Now Available at DeepResearchReports.com 3Equashield Enters Taiwan Following Expansion to Australia, Japan, China 2Dr. Ira Williams Offers the Healthcare Solution Necessary for Patient Safety Improvement 2Inivata Raises £4m to Realise the Potential of ctDNA Analysis to Improve Cancer Treatment Through Simple Blood Tests 2Inivata Raises £4m to Realise the Potential of ctDNA Analysis to Improve Cancer Treatment Through Simple Blood Tests 3Inivata Raises £4m to Realise the Potential of ctDNA Analysis to Improve Cancer Treatment Through Simple Blood Tests 4
... Austria, May 27 The atherosclerosis vaccine,development program ... the,EU,s EUROTRANS-BIO call. The respective project is being ... GmbH. The aim of,atherosclerosis vaccination is to increase ... in the blood and thus reduce the occurrence ...
... Efficiency and Manage Quality at New LIFE Nutrition Factory ... (NYSE: HON ) today announced that it ... manufacturer of healthcare products, to provide process control solutions ... and infusion therapy solutions. The Leading Infusion Factory Europe ...
... SEATTLE, May 27 /PRNewswire-FirstCall/ - Oncothyreon Inc. (Nasdaq: ... previously announced sale of 3,878,993 shares of its common stock ... for gross proceeds of approximately $11.1 million on May 26, ... unit (each unit consisting of one share and a warrant ...
Cached Biology Technology:AFFiRiS AG: Atherosclerosis Vaccine Development Receives EU Support 2AFFiRiS AG: Atherosclerosis Vaccine Development Receives EU Support 3Honeywell to Help B. Braun Healthcare Company Double Manufacturing Capacity of Life-Critical Products 2Honeywell to Help B. Braun Healthcare Company Double Manufacturing Capacity of Life-Critical Products 3Honeywell to Help B. Braun Healthcare Company Double Manufacturing Capacity of Life-Critical Products 4Oncothyreon announces closing of $11.1 million registered direct financing 2
(Date:9/23/2014)... consumption could be as good for your mental as ... conducted by the University of Warwick,s Medical School using ... by BMJ Open focused on mental wellbeing ... consistently associated with an individual,s fruit and vegetable consumption. ... five or more portions of fruit and vegetables a ...
(Date:9/23/2014)... including humans, have parasitic DNA fragments called "jumping genes" ... in the process. And that phenomenon can result in ... University of Rochester now report that the "jumping genes" ... a multi-function protein stops keeping them in check in ... a study published today in Nature Communications , ...
(Date:9/22/2014)... STATION The smell of cut grass in recent ... signalling distress, but new research says the aroma also ... is need for protection, the plant signals the environment ... recognized as a feeding queue for parasitic wasps to ... lay eggs in the pest insect," said Dr. Michael ...
Breaking Biology News(10 mins):Eating five a day may keep the blues away 2A multi-function protein is key to stopping genomic parasites from 'jumping' 2Mown grass smell sends SOS for help in resisting insect attacks, researchers say 2Mown grass smell sends SOS for help in resisting insect attacks, researchers say 3
... This release is available in Spanish . ... Medical Research (CIMA) of the University of Navarra has identified ... enzyme is involved in the accumulation of fibrous tissues in ... of heart functions. The research project, published in the ...
... April 21 More than 3,200 items of ... be displayed during the 2009 Force Protection Equipment ... VA, and Marine Corps Base, Quantico, VA, during ... of Defense, personnel with physical security responsibilities in ...
... losses and the environmental impact caused by invasive species ... alone. An example of this is the zebra mussel, ... to a New York Sea Grant report. In ... species, the armored catfish, or plecostomus, in the Infiernillo ...
Cached Biology News:Researchers identify a molecule that increases the risk of cardiac insufficiency 2Combating Terrorism with Commercial Technology: 2009 Force Protection Equipment Demonstration 2North America works to halt invasive species 2
Edited by D.M. Gersten (1996) Provides comprehensive descriptions of the techniques available for analytical gel electrophoresis of proteins and offers clear step-by-step protocols for all of the m...
...
All serum is collected from U.S.D.A. fryers and broilers. Pricing: $15/unit for 1 - 10 units; $12/unit for 11 - 50 units...
RAT ANTI MOUSE TCR V BETA 7:RPE Immunogen: T-cell lymphoma TK1...
Biology Products: