Two Metabolex Projects Recognized in Windhover's Top 10 Lists for Partnering Opp... (opportunities the industryhas to offer ...)

Two Metabolex Projects Recognized in Windhover's Top 10 Lists for Partnering Opportunities

Date:11/3/2008

opportunities the industry has to offer," said Roger Longman, Managing Director of Windhover Information. "Winners have met rigorous criteria including: unmet medical need, market potential, diversity of indications, strong science, multi-level partnering opportunities (biotech and pharma), potential for new opportunities beyond initial indications and corporate stability."

Metabolex plans to present information on MBX-2982 and MBX-8025 on November 4, 2008 at Windhover's Therapeutic Area Partnerships conference in Philadelphia, PA.

MBX-2982

MBX-2982 is an agonist of GPR119, a G protein-coupled receptor that is expressed in pancreatic islets and the gastrointestinal tract. Pre-clinical studies conducted by Metabolex and others show that GPR119 agonists can stimulate glucose-dependent insulin secretion and release of incretin hormones such as GLP-1, and thus may preserve beta cell health. This novel dual mechanism may provide a unique therapeutic benefit in the treatment of type 2 diabetes. Additionally, the stimulation of GLP-1 release may mimic the benefits of incretin analogues such as exenatide (a GLP-1 analogue marketed as Byetta(R)). Unlike exenatide, however, MBX-2982 can be delivered orally.

MBX-8025

MBX-8025 is a potent, selective PPAR-delta agonist that helps to regulate fatty acid degradation, lipid storage/transport and insulin sensitivity. MBX- 8025 is being developed to treat a range of dyslipidemias, and early research suggests it may have a broader effect on a number of lipid and metabolic parameters, including triglycerides, LDL and HDL cholesterol, insulin sensitivity and inflammation.

About Windhover

Windhover Information Inc., an Elsevier company, has provided analysis of the healthcare industry to decision-makers at all levels since the founding of its flagship publication, IN VIVO, The Business & Medicine Report, in 1983. Windhover provides its information and analysis in many formats, including pr
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Two Metabolex Projects Recognized in Windhover's Top 10 Lists for Partnering Opp...(opportunities the industryhas to offer ...)