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Tute Genomics appoints Dr. Mingfu Zhu as Director of Bioinformatics
Date:12/3/2013

SALT LAKE CITY, Dec. 3, 2013 /PRNewswire-iReach/ -- Dr. Mingfu Zhu, previously of the Duke Center for Human Genome Variation, has announced his new position with Tute Genomics as Director of Bioinformatics.  Dr. Zhu's extensive work with structural variation analysis of next-generation sequencing (NGS) data from whole genomes places Tute ahead of other analytic engines in applying structural variant knowledge for both research and clinical use.

(Photo: http://photos.prnewswire.com/prnh/20131203/MN27034)

This sub-specialty of NGS analysis carries significant value for identifying many conditions where structural variants, such as copy number variations (CNVs), are important yet go unnoticed because most software tools are not able to recognize them.  CNVs are the variation of the number of copies of a particular segment in a given genome.  They vary between genomes and are influential in susceptibility to certain diseases. 

One such disease category where copy number variations are critical for identification is neurodevelopmental disorders such as Autism.  Tute co-founder Dr. Kai Wang previously published CNV studies on various human diseases including autism spectrum disorders, schizophrenia, bipolar disorder, extreme obesity, Tourette syndrome, major depression, anorexia nervosa and others.  Both Dr. Wang and Tute CEO Dr. Reid Robison have also done collaborative work where they identified rare recurrent CNVs affecting glutamatergic neurotransmission genes that were overrepresented in certain childhood-onset neuropsychiatric conditions, such as Attention-Deficit Hyperactivity Disorder (ADHD). Additionally, Dr. Wang is the creator of PennCNV, one of the most widely used tools (with over 600 citations) for the
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