Navigation Links
Trudeau Institute announces a discovery in the fight against sepsis
Date:7/11/2011

Saranac Lake, N.Y. New research from the Trudeau Institute may help to explain why anticoagulant therapies have largely failed to extend the lives of patients with sepsis. The study was led by Deyan Luo, a postdoctoral fellow in Stephen Smiley's laboratory. It shows that fibrin, a key product of the blood clotting process, is critical for host defense against Yersinia enterocolitica, a gram-negative bacterium that causes sepsis in humans and experimental mice. The new data will be published in the August 15 issue of The Journal of Immunology and is available now online ahead of print.

"After inoculating a variety of genetically engineered mice with this bacterium, the lab observed that mice lacking fibrin showed dramatically decreased survival and harbored greatly increased numbers of bacteria in their blood and tissues," said Dr. Smiley. "These findings add to a growing body of evidence that fibrin helps to protect our bodies during infection."

Infectious disease remains a leading cause of death worldwide. Many of these deaths actually result, in large part, from our bodies' own excessive responses to certain types of infections. Whether the infectious agents first gain access to our bodies via a wound, intravenous line, or catheter, and whether they first establish infections in our skin, lung or intestine, all too often they evade our natural immune defense mechanisms and then spread, causing a generalized infection throughout much of the body.

Unless effective antibiotics are administered promptly, these generalized infections can lead to sepsis, a syndrome in which the immune system unleashes so much infection-fighting inflammation that it causes more damage than good, leading to organ failure, shock and death. With the ever-growing presence of multiple drug resistant bacteria like MRSA, the incidence of sepsis is increasing, even in state-of-the-art hospitals. Typically doctors simply tell family members that these deaths are caused by infection, but in many cases the true cause of death is sepsis.

One reason sepsis is difficult to treat is that the excessive inflammatory response prompts changes in another powerful system of our bodies, the blood clotting system. Blood is supposed to clot in response to trauma, as a means to prevent bleeding. However, the excessive inflammation that accompanies sepsis causes blood to clot within our blood vessels, even in the absence of trauma, thereby blocking blood flow and starving tissues of life-giving oxygen. It seems logical to treat sepsis patients with drugs that stop blood clotting (i.e. anticoagulants). However, anticoagulant therapies have largely failed to extend the lives of patients with sepsis. The Trudeau study provides a dramatic demonstration of the importance of the blood clotting process during sepsis, thus helping to explain why anticoagulants typically fail to help sepsis patients.

Additionally, the Trudeau study identified a number of molecular players key to regulating the levels of fibrin produced by the protective blood clotting pathway. The Smiley lab hypothesizes that drugs for sepsis will need to maintain these protective pathways, while preventing the excessive, oxygen-depriving, blood clotting that causes organ failure. Importantly, they identified at least one drug target that may allow them to selectively prevent the damaging blood clots while maintaining the protective fibrin. Specifically, they showed that the "extrinsic" blood clotting pathway is critical for protective clotting during sepsis whereas the "intrinsic" pathway appears to be dispensable. Ongoing studies aim to assess whether anticoagulant drugs that selectively block this intrinsic pathway will help to prevent deaths from infections that cause sepsis.


'/>"/>

Contact: Karen Sharma
518-891-3080
Trudeau Institute
Source:Eurekalert

Related biology technology :

1. Sorrento Therapeutics Innovative Approach to Developing Vaccines and Therapeutics for MRSA Receives Continued Support From the National Institute of Allergy and Infectious Diseases
2. Austen BioInnovation Institute in Akron Begins Work on Roadmap for First U.S. Accountable Care Community
3. Colorado Institute for Drug, Device and Diagnostic Development Awards Funding to Fort Collins-based VetDC
4. Karlsruhe Institute of Technology: Self-assembling electronic nano-components
5. Max Institute of Minimal Access, Metabolic & Bariatric Surgery Accredited as an International Centre of Excellence for Minimal Invasive Surgery
6. David H. Murdock Research Institute Assumes Control of the Immune Tolerance Institute and Establishes a State of the Art Human Immune Monitoring Laboratory for Biomarker Discovery and Development
7. Arteriocyte and the U.S. Army Institute of Surgical Research (USAISR) Sign a CRADA to Speed Development of Cellular Therapies for Orthopaedic Trauma
8. Ontario Institute for Cancer Research Announces Spin Off Companies Developing Promising Anticancer Technologies
9. Ludwig Institute for Cancer Research and Polaris Group Form Collaboration to Expand Development of Polaris Novel Cancer Drug, ADI-PEG 20
10. Northwest Biotherapeutics and the Fraunhofer Institute for Cell Therapy and Immunology are Partnering for Clinical Trials and Compassionate Use Cases in Europe
11. Larta Institute Receives Award for National Institutes of Health Commercialization Assistance Program at 2011 Acquisition, Grants, and Small Business Symposium
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... ... February 10, 2016 , ... PatientCrossroads ... on the secure online PatientCrossroads platform, has exceeded both its one-year and overall ... the PROMPT study, which seeks to advance understanding of the hereditary risks for ...
(Date:2/10/2016)... ... ... Cenna Bioscience Inc., an emerging biopharmaceutical company focused on the discovery and ... been selected to present at the Cavendish Global Health Impact Forum taking place February ... of the Forum is to help family offices and foundations develop and implement their ...
(Date:2/9/2016)... N.J. , Feb. 9, 2016  Regenicin, ... biotechnology company specializing in the development and commercialization ... of damaged tissues and organs, recently reported the ... the first quarter of 2016. Lonza ... the new 2015 fiscal year in the process ...
(Date:2/9/2016)... ... February 09, 2016 , ... Clinovo , the ... validated Electronic Data Capture (EDC) system ClinCaptureand its new Contract Research Organization (CRO) ... 2016 Conference in San Mateo, California on February 10th and 11th. Watch ...
Breaking Biology Technology:
(Date:1/27/2016)... WEST CHESTER, Ohio , Jan. 27, 2016 /PRNewswire/ ... services supplier based in West Chester, Ohio ... and their award winning service staff, based in ... Track,s technical capacity and ability to provide modifications, installations ... John Dovalina , CEO of PLUS, commented, "PLUS ...
(Date:1/22/2016)... , Jan. 22, 2016 ... the addition of the "Global Biometrics ... to their offering. --> ... the "Global Biometrics Market in Retail ... --> Research and Markets ...
(Date:1/20/2016)... Calif. , Jan. 20, 2016  Synaptics ... of human interface solutions, today announced sampling of ... solution for wearables and small screen applications including ... as printers. Supporting round and rectangular shapes, as ... offers excellent performance with moisture on screen, while ...
Breaking Biology News(10 mins):