Navigation Links
Trudeau Institute announces a discovery in how FluMist elicits protection
Date:8/23/2011

Saranac Lake, N.Y. New research from the Trudeau Institute may help to explain why live attenuated influenza vaccine (LAIV), commonly known as FluMist, elicits protection. The research is published in this month's issue of Vaccine. The journal article is entitled "Live attenuated influenza vaccine (LAIV) impacts innate and adaptive immune responses" and was authored by Trudeau Institute scientist Dr. Laura Haynes and her colleagues.

"Our research specifically examines how the vaccine, which is commonly known as FluMist, elicits protection," said Dr. Laura Haynes. "Influenza infection normally induces a massive inflammatory response in the lungs that leads to significant illness and increases the susceptibility to secondary bacterial infections. The most efficient way to prevent influenza infection is through vaccination. To date, the mechanism of how FluMist induces protection has been unclear. Our study demonstrates that this vaccine works by inducing a very early non-specific immune response in the lungs in a mouse model of influenza infection."

The very early non-specific immune response sets the stage for the early influx of virus-specific immune cells, which are necessary for viral clearance. Importantly, this immune response is protective against both matching and non-matching influenza strains, therefore it could provide a level of protection in the case of a newly emergent influenza strain.

In addition, this very early immune response also serves to limit lung inflammation by significantly reducing the levels of inflammatory cytokines and chemokines produced following influenza infection. This novel finding provides insight into how this influenza vaccine functions and is important because inflammation is a major cause of damage in the lungs and this can set the stage for secondary bacterial infections, which are quite common following influenza infection.

The study goes on to show that the LAIV vaccine also induces a robust immune response in healthy adult volunteers. These translational experiments were carried out in collaboration with the Respiratory Diseases Research Department at the Naval Health Research Center (NHRC) in San Diego, CA and were the result of a joint Trudeau/Department of Defense contract.

Subjects were recruited by NHRC and were administered the commercially available FluMist vaccine. At specific time points following vaccination, the immune response to the vaccine was examined. Following LAIV vaccination, chemokines and cytokines involved in virus-specific lymphocyte recruitment were produced. This is indicative of a protective immune response and would lead to the early recruitment of immune cells to the lung should influenza infection occur. Importantly, early recruitment of immune cells to the lung is highly desirable since this then leads to accelerated viral clearance and reduced levels of inflammation.


'/>"/>

Contact: Karen Sharma
ksharma@trudeauinstitute.org
518-891-3080
Trudeau Institute
Source:Eurekalert

Related biology technology :

1. Trudeau Institute announces a discovery in the fight against sepsis
2. Repair Stem Cell Institute Announces Industrys First Standards of Excellence for Global Stem Cell Treatment Centers to Protect Patients from Less-than-Competent Therapeutics
3. BN ImmunoTherapeutics Announces Partnership With National Cancer Institute
4. Rosetta Genomics and the National Institute of Health (NIH) to Identify Potential MicroRNA Drug Targets for HIV
5. Cyntellect to Collaborate With the Burnham Institute for Medical Research
6. Memory Pharmaceuticals Closes Final Tranche of Equity Financing with The Stanley Medical Research Institute
7. The National Cancer Institute Joins the Global Community of Scientists Now Using BIOMARKERcenter From Thomson Reuters
8. Stem Cell Profits Five Years Away, Says Repair Stem Cell Institute Chairman to The Wall Street Transcript
9. Pressure BioSciences, Inc. Announces Research Agreement With the US Army Medical Research Institute of Infectious Diseases (USAMRIID)
10. Epeius Biotechnologies Lead Product, Rexin-G for Metastatic Cancer, Aptly Highlighted by National Cancer Institute Journal
11. Annual List of Best Doctors in Dallas Showcases Texas Institute for Surgery Physicians
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... 24, 2016  Regular discussions on a range of subjects ... the two entities said Poloz. Speaking at a ... , he pointed to the country,s inflation target, which ... "In certain areas ... have common economic goals, why not sit down and address ...
(Date:6/23/2016)... ... June 23, 2016 , ... Mosio, a ... eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced clinical research ... by providing practical tips, tools, and strategies for clinical researchers. , “The landscape ...
(Date:6/23/2016)... -- A person commits a crime, and the detective uses ... criminal down. An outbreak of foodborne illness makes ... uses DNA evidence to track down the bacteria that caused ... not. The FDA has increasingly used a complex, cutting-edge technology ... Put as simply as possible, whole genome sequencing is a ...
(Date:6/23/2016)... YORK , June, 23, 2016  The Biodesign ... to envision new ways to harness living systems and ... Modern Art (MoMA) in New York City ... than 130 participating students, showcased projects at MoMA,s Celeste ... Paola Antonelli , MoMA,s senior curator of architecture ...
Breaking Biology Technology:
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 ... subsidiary of Infosys (NYSE: INFY ), and Samsung ... global partnership that will provide end customers with a ... and payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ... for financial services, but it also plays a fundamental part ...
(Date:4/19/2016)... DUBAI , UAE, April 20, 2016 ... can be implemented as a compact web-based "all-in-one" system ... in the biometric fingerprint reader or the door interface ... requirements of modern access control systems. The minimal dimensions ... the ID readers into the building installations offer considerable ...
(Date:4/13/2016)... , April 13, 2016  IMPOWER physicians supporting ... are setting a new clinical standard in telehealth thanks ... By leveraging the higi platform, IMPOWER patients can routinely ... pulse and body mass index, and, when they opt ... and convenient visit to a local retail location at ...
Breaking Biology News(10 mins):