Navigation Links
Trudeau Institute Awarded Grant to Investigate a New Approach to Treating Illnesses Caused by Weaponized and Antibiotic-Resistant Bacteria
Date:12/20/2012

Saranac Lake, New York (PRWEB) December 20, 2012

Trudeau Institute faculty member Stephen T. Smiley, Ph.D., has been awarded a grant to evaluate new strategies for improving patient survival after a bacterial infection. If successful, his strategy would work against many types of serious infections that spread throughout the body, including those caused by deadly weaponized or antibiotic-resistant bacteria. The research will be funded by a grant from the National Institute of Allergy and Infectious Diseases (NIAID), via the Northeast Biodefense Center. The studies will advance NIAID goals by defining basic principles of immunity while advancing a new, broadly applicable paradigm for the treatment of life-threatening bacterial infections.

The Research Project
Supplying immune defense therapeutically, by injecting patients with protective antibodies, can be an effective treatment for life-threatening infections. This ‘immunotherapy’ may be the best treatment option for infections caused by antibiotic-resistant bacteria. However, it can be difficult, and costly, to deliver sufficiently high quantities of antibodies to human patients. Moreover, antibodies often fail to stop bacterial infections immediately. Rather, they typically slow bacterial growth, thus providing time for the patient’s immune system to ramp up and clear the infection.

Given the relatively slow clearance of bacterial infections by immunotherapy, co-treatments that suppress damage caused by infections should synergize with immunotherapy to improve overall survival. Much of the damage caused by bacterial infections is caused by sepsis, an infection-induced syndrome characterized by excessive inflammation and dysregulated coagulation. Despite its potential to cause damage, Dr. Smiley’s prior studies establish that coagulation also can be essential for immune defense against bacteria. This observation suggests that sepsis therapeutics should strive to control, but not completely prevent, coagulation.

This new funding from the Northeast Biodefense Center will help Dr. Smiley test the hypothesis that treatments that reduce coagulation will synergize with low-dose immunotherapy to improve survival during bacterial infection.

About the Northeast Biodefense Center
Founded in 2003 and headquartered at Columbia University in the City of New York, the Northeast Biodefense Center (NBC) is a consortium of academic and governmental biomedical research institutions from New York State, New Jersey, Connecticut, and strategic partners in other states. NBC is one of eight U.S. Department of Health and Human Services-designated regional biodefense centers.

About the Trudeau Institute
The Trudeau Institute is a nonprofit biomedical research center founded in 1884 by Dr. E.L. Trudeau. The Institute's fundamental research on immunity fosters the development of vaccines, treatments and cures for many life-threatening diseases, including cancer, tuberculosis and influenza. The Institute is supported by federal and state grants and contributions from individuals, private foundations and corporations. For further information about the Trudeau Institute, go to http://www.trudeauinstitute.org.

###

Press Contact
Kim Godreau
Trudeau Institute
kgodreau(at)trudeauinstitute(dot)org
(518) 891-3080, ext. 561

Read the full story at http://www.prweb.com/releases/2012/12/prweb10258569.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related biology technology :

1. The Veterinary Bioscience Institute's 2012 Year in Review
2. Veterinary Bioscience Institute (VBI) and a-tune software, Inc. Partnership
3. Harvards Wyss Institute team creates versatile 3d nanostructures using DNA bricks
4. Craft Beverage Institute of the Southeast Formed at A-B Tech
5. Diabetes Research Institute Foundation’s (DRIF) CEO Joins Healthcare Holdings Group, Inc. Board of Directors
6. First Effective Treatment For Traumatic Brain Injury Reported by Institute of Neurological Recovery, Even Years After Injury
7. Harvards Wyss Institute models a human disease in an organ-on-a-chip
8. Van Andel Institute Research Symposium Showcases Latest Developments In Parkinsons Research
9. Genetics Policy Institute (GPI) Collaborates on Second Midwest Conference on Stem Cell Biology and Therapy, Oct. 5-7 at Oakland University
10. California Healthcare Institute Issues Statement on Supreme Court Ruling on the Affordable Care Act
11. Scripps Research Institute scientists find easier way to make new drug compounds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... 24, 2017 Sinovac Biotech Ltd. ("Sinovac" or the "Company") ... China , today announced that its board of directors has ... the plan from March 27, 2017 to March 27, 2018. The amendment ... About Sinovac Biotech Ltd. ... Sinovac Biotech Ltd. is a China ...
(Date:3/23/2017)... ... 23, 2017 , ... Lajollacooks4u is proud to announce it has become the premiere team-building cooking ... for companies around the world, such as Illumina, HP and Qualcomm, and is ranked #1 ... increasing popularity is due to its new team building format, a way for teams to ...
(Date:3/23/2017)... -- BioPharmX Corporation (NYSE MKT: BPMX), a specialty pharmaceutical ... reported financial results for the quarter and year ... update on the company,s clinical development efforts and ... pleased to report that last year was a ... Krammer. "We achieved key clinical milestones and attracted ...
(Date:3/23/2017)...  Agriculture technology company Cool Planet has closed on ... to commercialize its Cool Terra and Cool Fauna Engineered ... that are simultaneously profitable as well as sustainable and ... months. This latest round of funding was led by ... The company,s primary product, Cool Terra, can improve ...
Breaking Biology Technology:
(Date:3/9/2017)... , March 9, 2017 4Dx has publicly ... Lung Imaging Workshop at the University of Pennsylvania. Founder ... to deliver the latest data to world leaders in ... brings together leaders at the forefront of the industry ... imaging. "The quality of the imaging ...
(Date:3/6/2017)... SAN MATEO, Calif. , March 6, 2017 ... predictive marketing and sales technology, today announced Predictive ... (AI) solution for infusing actionable sales intelligence into ... customers to automatically enable their sales organizations with ... contextual messages that allow for intelligent engagement. Predictive ...
(Date:3/2/2017)... , March 2, 2017 Australian stem ... (ASX: CYP), has signed an agreement with the ... the Monash Biomedicine Discovery Institute and Department of Pharmacology ... conduct a further preclinical study to support the use ... of asthma.  Asthma is a chronic, ...
Breaking Biology News(10 mins):