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Trubion Reports Re-treatment Results Following Phase 1/2a and Phase 2b Studies Evaluating TRU-015 for Rheumatoid Arthritis
Date:10/27/2008

e-treated with 800 mg of TRU-015 were 70%, 40% and 23%, respectively. Re-treatment with TRU-015 was generally well-tolerated. The safety and PD effects after re-treatment were comparable to those seen after initial therapy.

"We are very pleased with the results from the first course of re-treatment under the Phase 2b study protocol," said Peter Thompson, M.D., FACP, president, CEO and chairman of Trubion. "These data demonstrate improvement in RA signs and symptoms and, combined with data from more than 130 re-treatment courses administered over two years under the Phase 1/2a study, continue to validate TRU-015 as a potential therapy for the treatment of RA."

About Trubion

Trubion is a biopharmaceutical company that is creating a pipeline of novel protein therapeutic product candidates to treat autoimmune and inflammatory diseases and cancer. The company's mission is to develop a variety of first-in-class and best-in-class product candidates, customized for optimal safety, efficacy and convenience that it believes may offer improved patient experiences. Trubion's current product candidates are novel single-chain protein, or SMIP(TM), therapeutics, and are designed using its custom drug assembly technology. Trubion's product pipeline includes CD20-directed SMIP therapeutics such as TRU-015 and SBI-087 for autoimmune and inflammatory diseases, developed under the company's collaboration with Wyeth Pharmaceuticals. Trubion's product pipeline also includes Trubion's proprietary product candidate, TRU-016, a novel CD37-targeted therapy for the treatment of B-cell malignancies that is currently in Phase 1/2 clinical evaluation. In addition to Trubion's current clinical stage product pipeline, the company is also developing additional product candidates that build on its product development experience. More information is available in the investors section of Trubion's website: http://www.trubion
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SOURCE Trubion Pharmaceuticals Inc.
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