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Trubion Presents Preclinical Data on Its SCORPION(TM) Multispecific Therapeutics at the 2009 American Association of Cancer Research Annual Meeting
Date:4/22/2009

e same target, but can bind both targets simultaneously. Results showed the CD79BxDR SCORPION molecule elicited strong Antibody-Dependent Cellular Cytotoxicity (ADCC) as well as highly potent direct killing, confirming the ability of Trubion's SCORPION molecules to retain key effector functions that are known to be related to efficacy of monoclonal antibodies. In addition, the data also demonstrated in assays against the NHL-derived DoHH2 cell line, that Trubion's SCORPION multispecific therapeutic was 100 times more potent than both rituximab and the combination of the individual mono-specific SMIP molecules against the respective CD79B and HLA-DR targets. This enhanced potency was shown to be restricted to the depletion of B-cells when in the presence of T cells, as 48 hour incubation with primary human peripheral blood mononuclear cells showed selective depletion of B (CD19+) but not T (CD3+) cells.

A copy of this poster presentation is available on Trubion's website at http://investors.trubion.com/events.cfm.

Trubion's SCORPION(TM) Therapeutics

Like Trubion's SMIP(TM) therapeutics -- single-chain polypeptides comprising one binding domain, one hinge domain and one effector domain -- SCORPION therapeutics are also novel, single-chain polypeptides comprised of functional domains from naturally occurring proteins. However, SCORPION therapeutics are multispecific therapeutics that are capable of targeting two or more antigens simultaneously. Trubion's SCORPION format provides the basis for development of single therapies that simultaneously inhibit multiple ligand/receptor interactions or that manipulate cellular signaling pathways by cross-linking multiple cell surface receptors. SCORPION therapeutics have long in vivo half-lives, can have other intact effector f
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SOURCE Trubion Pharmaceuticals, Inc.
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