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Trubion Announces Acceptance of Three Presentations on Its TRU-016 Product Candidate at the 2009 ASCO Annual Meeting
Date:5/14/2009

and bendamustine resulted in greater efficacy compared to the efficacy attained with the individual drugs. These studies demonstrate that TRU-016 combined with rituximab, rapamycin, or bendamustine increases cell killing of NHL cells. Furthermore, the combination of TRU-016 and bendamustine displayed greater in vivo anti-tumor activity than either agent alone against a follicular lymphoma tumor model.

Abstract 3035 (May 30, 2009): Effect of CD37 Small Modular ImmunoPharmaceutical (SMIP) on direct apoptosis in chronic lymphocytic leukemia cells via transcriptional up-regulation of the BH3 family member BIM

Given the superior in vitro apoptosis observed with TRU-016 treatment and early clinical activity observed in highly refractory CLL patients, preclinical studies were performed on CLL cells to determine the mechanism(s) of direct TRU-016 mediated apoptosis. These studies demonstrate TRU-016-mediated apoptosis in CLL cells occurs via a distinct mechanism of apoptosis compared with many other therapeutic agents utilized for the treatment of CLL.

"The data to be presented at ASCO expands our pre-clinical experience and reinforces our belief that TRU-016 has the potential to improve treatment options for patients with B-cell malignancies like CLL and NHL," said Peter Thompson, M.D., FACP, president, CEO and chairman of Trubion. "Patients with relapsed or refractory disease often show steadily diminished response to current therapies. The preliminary data from the Phase 1 study are very encouraging as TRU-016 shows the potential to produce promising single-agent clinical activity in patients whose disease is recurring or patients who are no longer responding to prior treatments. The demonstrations that TRU-016 works through a novel and powerful mechanism of action, synergizes in vitro with a broad array of small molecule therapeutics, and shows significant in vivo efficacy in combination with bendamustine add to our ent
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SOURCE Trubion Pharmaceuticals, Inc.
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