Navigation Links
Tricking algae's biological clock boosts production of drugs, biofuels
Date:11/7/2013

ed that the clock consisted of three proteins: KaiA, KaiB and KaiC. Detailed knowledge of the clock's structure allowed them to determine how to switch the clock on and off.

In the current study, the researchers discovered that two components of the clock, KaiA and KaiC, act as switches that turn the cell's daytime and nighttime genes on and off. They have dubbed this "yin-yang" regulation. When KaiA is upregulated produced in larger amounts and KaiC is downregulated produced in smaller amounts then the 95 percent of cell's genes that are active during daylight are turned on, and the 5 percent of the cell's genes that operate during the night are turned off. However, when KaiC is upregulated and KaiA is downregulated then the day genes are turned off and the night genes are turned on.

"As a result, all we have to do to lock the biological clock into its daylight configuration is to genetically upregulate the expression of KaiA, which is a simple manipulation in the genetically malleable cyanobacteria," Johnson said.

To see what effects this capability has on the bacteria's ability to produce commercially important compounds, the researchers inserted a gene for human insulin in some of the cyanobacteria cells, a gene for a fluorescent protein (luciferase) in other cells and a gene for hydrogenase, an enzyme that produces hydrogen gas, in yet others. They found that the cells with the locked clocks produced 200 percent more hydrogenase, 500 percent more insulin and 700 percent more luciferase when grown in constant light than they did when the genes were inserted in cells with normally functioning clocks.


'/>"/>

Contact: David Salisbury
david.salisbury@vanderbilt.edu
615-343-6803
Vanderbilt University
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. Two Top Biological Imaging Centers Offer Powerful Free Online Tool to Researchers, Educators, and Public
2. Chemring Detection Systems Awarded $9M for Biological Detection Systems
3. Scientists develop tools to make more complex biological machines from yeast
4. Biodetection 2012 Conference Brings Together Leading Organizations from Around the World to Address Challenges & Technology Advances in Detection and Identification of Biological Threats in Washington, DC from June 28-29, 2012
5. "Biological Control Industry Overview: Companies & Products" Edition 2 is Here. Critical information for Understanding the Global Biopesticide/Biocontrol Market
6. PhoenixSongs Biologicals, Inc. Announces Enhanced Neural Lineage-specific Cell Culture Media Products Release
7. Society of Biological Psychiatry and Elsevier Renew Publishing Agreement
8. Three Hertz Foundation Fellows Receive Presidential Honors; Leaders in Applied Physical, Biological and Engineering Sciences
9. GenScript Announces Collaboration with AMDeC: Seeks to Decrease Biological Research Costs at NYC Area Institutions
10. Uncovering the Meaning in Your NGS Data: Tackling the Biological Analysis and Interpretation of Sequence Variation
11. Novus Biologicals Hires David Eansor to Lead New Corporate-Development Effort
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tricking algae's biological clock boosts production of drugs, biofuels
(Date:7/11/2014)... 2014 /CNW/ - Sunovion Pharmaceuticals Canada Inc. (Sunovion) today ... acetate) for use as a once-daily adjunctive therapy for ... who are not satisfactorily controlled with conventional therapy.  APTIOM ... under 18 years of age. Epilepsy ... according to Epilepsy Canada, it affects 0.6% of the ...
(Date:7/10/2014)... 2014 Product and process impurities ... abundance and are often “lost in the noise,” ... Join presenters Dr. Rowel Tobias, Senior Scientist, Protein ... Head of Quality at Nanotherapeutics, Inc., to lear ... speed detection and quantitation while achieving the required ...
(Date:7/10/2014)... 2014 Unraveling life’s mysteries can intrigue, ... Archer Family purchased a DNA test to ... up with a lifetime of memories, sharing, and closeness. ... members’ DNA genuinely brought the family closer together. ... into genetic history and prior to taking the ...
(Date:7/10/2014)... (PRWEB) July 10, 2014 Senior supply ... and professional associations, addressed the challenges of “Reducing Cost, ... Device Industries” through strategic sourcing. Describing the partnership of ... the Supply Chain Management Institute ( SCMI) of ... on June 24 at the Kroc Institute of Peace ...
Breaking Biology Technology:Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 2Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 3Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 4Novel Ms Techniques Speed Detection of Biopharmaceutical Product and Process Impurities, New Webinar Hosted by Xtalks 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4
... sunlight at a modest cost is a challenge with ... paper in a special energy issue of Optics ... a relatively new approach to solar cells: lacing them ... the article, this approach has the potential to greatly ...
... GREENBELT, Md. - Engineers at the University of Idaho ... in upcoming NASA missions that will study the Earth ... of a grant technical officer Pen-Shu Yeh, a senior ... the engineering team at the University of ...
... Md. - Engineers at the University of Idaho have ... upcoming NASA missions that will study the Earth and ... a grant technical officer Pen-Shu Yeh, a senior engineer ... engineering team at the University of Idaho,s ...
Cached Biology Technology:Enhancing solar cells with nanoparticles 2New one-of-a-kind technology will fly on 2 NASA missions 2New one-of-a-kind technology will fly on 2 NASA missions 3New one-of-a-kind technology will fly on two NASA missions 2New one-of-a-kind technology will fly on two NASA missions 3
(Date:7/11/2014)... Researchers from Salk Institute for Biological Studies, BGI, ... the safety and reliability of the existing targeted ... method, TALEN-HDAdV, which could significantly increased gene-correction efficiency ... study published online in Cell Stell Cell ... cell-based gene therapy. , The combination of stem ...
(Date:7/11/2014)... July 11, 2014 Researchers have pioneered a ... The new technology, called Virtual Finger, allows scientists ... like neurons and synapses using the flat surface ... makes 3D imaging studies orders of magnitude more ... unprecedented level across many areas of experimental biology. ...
(Date:7/11/2014)... is evidence that under the normal circumstances, ... development, maintain neuronal environment, and exhibit therapeutic ... neurodegenerative disease. Previous studies have found that ... after chemical induction have reduced viability, which ... Prof. Xiaodong Yuan, Kailuan General Hospital, Hebei ...
Breaking Biology News(10 mins):A new genome editing method brings the possibility of gene therapies closer to reality 2Virtual finger enables scientists to navigate and analyze complex 3D images 2
... varieties with higher yields and enhanced nutritional content, researchers ... with scientists at nine other institutions in an attempt ... endeavor, led by researchers at the U.K.-based Biotechnology and ... in the journal Nature . "This work ...
... release is available in Spanish . WASHINGTON, ... as part of an international team have completed a "shotgun sequencing" ... Nature reported today. The achievement is expected to increase ... wheat varieties with enhanced nutritional value. "By unlocking the ...
... code of one of the world,s most important crops. The ... genome, published today in Nature , is a major ... better able to cope with disease, drought and other stresses ... wheat genes, and insights into the links between them, lays ...
Cached Biology News:UC Davis researchers aid effort to sequence the complex wheat genome 2USDA scientists and cooperators sequence the wheat genome in breakthrough for global food security 2USDA scientists and cooperators sequence the wheat genome in breakthrough for global food security 3Major breakthrough in deciphering bread wheat's genetic code 2Major breakthrough in deciphering bread wheat's genetic code 3Major breakthrough in deciphering bread wheat's genetic code 4
... The VSOS-4 Orbital Shaker is designed to ... provide a uniform motion that is both mixing ... VSOS-4 Orbital Shaker provides a smooth, quiet, reproducible ... a wide range of laboratory applications such as ...
... Titer Kit is designed for determination of baculovirus ... days as in other methods. Classical determination of ... plaques, but the FastPlax Kit takes advantage of ... glycoprotein on the cell surface as early as ...
... state-of-the-art software for all your biopharmaceutical applications ... a single, scalable software package. The graphical ... the control of all Freedom instruments from ... 100 with one liquid handling arm up ...
... Kit is an advanced system for isolating DNA from ... be used directly for any downstream application. ... to use in 56 minutes Low melting point ... and TBE gels No specialised equipment required ...
Biology Products: