Navigation Links
Triangles guide the way for live neural circuits in a dish
Date:7/19/2012

Korean scientists have used tiny stars, squares and triangles as a toolkit to create live neural circuits in a dish.

They hope the shapes can be used to create a reproducible neural circuit model that could be used for learning and memory studies as well as drug screening applications; the shapes could also be integrated into the latest neural tissue scaffolds to aid the regeneration of neurons at injured sites in the body, such as the spinal cord.

Published today, 20 July, in IOP Publishing's Journal of Neural Engineering, the study, by researchers at the Korea Advanced Institute of Science and Technology (KAIST), found that triangles were the most effective shape for helping to facilitate the growth of axons and guide them onto specific paths to form a complete circuit.

Co-author of the study, Professor Yoonkey Nam, said: "Eventually, we want to know if we can design a neural tissue model that biologically mimics some neural circuits in our brain."

A neuron is an electrically excitable cell that processes and transmits information around the body. The neuron is composed of three main parts: a cell body, or soma, dendrites and an axon, which extends from the soma and links to other cells, creating a network.

When axons grow they are usually guided by proteins. Many researchers have been trying to re-create this key process in a dish by manipulating nerve cells from rat brains.

As nerve cells are usually just a few tens of micrometres in size, the challenge associated with creating a live neural network is firstly positioning cells in desired locations and, secondly, making connections between these cells by guiding the axons in designated directions.

The researchers investigated whether two star shapes, five regular shapes (square, circle, triangle, pentagon and hexagon) and three different sizes of isosceles triangles could guide axons in designated directions. Each shape was the size o
'/>"/>

Contact: Michael Bishop
michael.bishop@iop.org
44-117-930-1032
Institute of Physics
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Researchers love triangles
2. JBT Corporation and Swisslog Enter Into Partnership for Automated Guided Vehicles
3. The ABC Clinical Guide to Herbs Now Available Online
4. Neuralstem ALS Stem Cell Trial Featured on Fox Atlanta
5. Neuralstem President and CEO to Update Ongoing ALS and NSI-189/Major Depressive Disorder Trials at 2012 Biotech Showcase
6. Neuralstem President and CEO to Present at BIO CEO & Investor Conference 2012
7. Neuralstem Announces Closing of $5.2-Million Registered Direct Offering
8. Fourteenth Patient Dosed in Neuralstem ALS Stem Cell Trial
9. Neuralstem CEO to Present at the World Stem Cells and Regenerative Medicine Congress in London
10. UCLA researchers demonstrate fully printed carbon nanotube transistor circuits for displays
11. Researchers develop one of the worlds smallest electronic circuits
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/4/2015)... March 4, 2015 In an article published ... Center for Health Security review the clinical aspects of ... used as bioweapons. The article, "Clinical Management of Potential ... the website of the New England Journal of ... Eric Toner , and Tom Inglesby—review the clinical management ...
(Date:3/4/2015)... March 04, 2015 USDM Life ... the life sciences industry, hired David Blewitt ... Cloud Compliance Services and Solutions at USDM Life ... based applications while maintaining compliance with government regulations worldwide. ... been an accomplished life sciences regulatory and IS compliance ...
(Date:3/4/2015)... 2015 /CNW/ - Resverlogix Corp. (TSX:RVX) (the "Company") ... collaborative research program with Emerald Logic, a ... Evolution Technology (FACET), Emerald Logic analyzed Resverlogix,s ... from each of 798 patients who participated ... ASSERT, SUSTAIN and ASSURE. The objective of ...
(Date:3/4/2015)... REDWOOD CITY, Calif. , March 4, 2015 ... ACRX ), a specialty pharmaceutical company focused on ... the treatment of acute and breakthrough pain, today ... yearly 2014 financial results after market close on ... an investment-community conference call at 4:30 p.m. Eastern ...
Breaking Biology Technology:Latest Clinical Information On Bioterrorism Threats 2USDM Life Sciences Names David Blewitt VP of Cloud Compliance for Regulated Life Sciences 2USDM Life Sciences Names David Blewitt VP of Cloud Compliance for Regulated Life Sciences 3Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 2Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 3Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 4AcelRx Pharmaceuticals to Hold Annual 2014 Financial Results Conference Call and Webcast on Monday, March 9th, 2015 2AcelRx Pharmaceuticals to Hold Annual 2014 Financial Results Conference Call and Webcast on Monday, March 9th, 2015 3
... businesses to better meet the needs of customers and ... usability conference titled Are Your Web Based Solutions Accessible, ... by the Madison chapter of Media Communications ... standards to designing Web pages for ease of use ...
... University of Wisconsin Hospital has completed its hospital-wide ... the final system being implemented in the hospital's pediatric ... , is now operational in all 22 of the ... administration errors by 87 percent. This reduction is possible ...
... children growing up poor, money isn't the only solution ... a new study, the genes and warm support received ... of the cognitive and behavioral problems for which poverty ... the May issue of the journal Child Development. , ...
Cached Biology Technology:Special needs addressed at Web Usability Conference 2UW Hospital completes deployment of error-reducing technology 2UW Hospital completes deployment of error-reducing technology 3Study shows that genes can protect kids against poverty 2Study shows that genes can protect kids against poverty 3
(Date:2/5/2015)... TRIANGLE PARK, North Carolina , 5. ... sein 35. Jahr als spezialisiertes Logistikunternehmen und ... Position als einzige klinische Logistikfirma (Clinical Logistics ... Die Kernbotschaft der neuen Kampagne lautet ... und Lieferungen. Foto: http://photos.prnewswire.com/prnh/20150205/173753 ...
(Date:2/5/2015)... 26, 2015   Epic Sciences , a precision diagnostics ... that Murali Prahalad , Ph.D., president and CEO, is ... (PMWC) 2015: Silicon Valley, which is taking place at ... on January 26-28, 2015. Dr. ... as Biomarkers." Last year, Epic Sciences was a finalist in ...
(Date:2/5/2015)... , Jan. 27, 2015   ... of globally deployed, innovative test solutions for ... the delivery of its TS-323 GENASYS ... Systems Company (LMSSC). GENASYS is a high-performance ... of mission-critical applications that require performance functional ...
Breaking Biology News(10 mins):Marken startet Kampagne mit Patienten im Mittelpunkt 2Marken startet Kampagne mit Patienten im Mittelpunkt 3Epic Sciences to Present at Personalized Medicine World Conference 2015 on the Use of Circulating Tumor Cells as Cancer Biomarkers 2Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 2Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 3Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 4
... molecule embedded in the membrane of human liver cells that ... C virus, the first step in hepatitis C infection, according ... of Medicine. The cholesterol receptor offers a promising new ... already exist, say the researchers, whose findings were reported online ...
... 2012) - The many factors that contribute to how cells ... not fully understood, but researchers at Baylor College of ... intracellular membranes fuse, and in the process, created a new ... the current edition of the journal PLoS Biology . ...
... (NASDAQ: CYTX) announced today the publication of previously ... clinical trial evaluating adipose-derived stem and regenerative cells ... attack or AMI), as Research Correspondence in the ... . The APOLLO trial was a 14-patient, prospective, ...
Cached Biology News:Entry point for hepatitis C infection identified 2Membrane fusion a mystery no more 2Adipose stem cell heart attack trial data published in JACC 2
muscle actin (HUC1-1)...
... Cell Functional Identification Kit contains specially ... used for the short-term maintenance, differentiation, ... induction of NSCs into astrocyte, neuron ... consisting of mouse anti-human Nestin, mouse ...
FluoSpheres® biotin-labeled microspheres, 0.2 µm, yellow-green fluorescent (505/515) *1% solids*...
Rat Antibody to Kinase Suppressor Of Ras Recognises the kinase suppressor of Ras (KSR). Immunogen: Recombinant human KSR protein Specificity: human kinase supressor of Ras...
Biology Products: