Navigation Links
Treatment for overactive bladder and irritable bowel syndrome advanced through pioneering research

Researchers at the University of Surrey have discovered how the receptors responsible for contractions in the bladder, regulate the body's clock genes.

The new study, published today in The FASEB Journal, has found that this clock activity in turn regulates the cycle of all cells in the body. The team of researchers also discovered that the local biological clock and its control are weakened in ageing bladders, demonstrating the importance of the clock in bladder physiology and ageing.

While currently much is known about the central biological clock, little is known about the peripheral clocks in the body. This latest research challenges the long-held view that the central clock of the brain controls all the peripheral clocks in other parts of the body and that these in turn control the down-stream receptor molecules which generate specific cell activities, such as contraction, secretion and metabolism. However, researchers have found that receptors in the bladder, a muscular hollow organ in the body, exert control over the local clocks. The control of organ function via an interaction between the peripheral clocks and the receiving receptors is an important finding for understanding the pathology and development of new treatments for common diseases of the bladder, such as bladder overactivity and irritable bowel syndrome.

The team also believes the study will help advance understanding of how ageing affects organ function in the body as the normal control of daily rhythms by the clock is weakened in ageing tissue.

"Previously, people have believed that the brain 'master' clock controls the 'slave' peripheral clocks, but our study is the first to show that in a contractile organ, such as the bladder, its receptors also control these clocks," said lead author Dr Changhao Wu from the University of Surrey.

"By influencing the receptors in the bladder, we can also change our clock genes. These clocks are crucial in maintaining our physiological rhythm and preventing unwanted activities associated with an overactive bladder."


Contact: Peter La
University of Surrey

Related biology technology :

1. BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite
2. Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S.
3. Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify
4. Synthetic Biologics Academic Collaborator to Present Novel Monoclonal Antibody Combination for Treatment of Whooping Cough (Pertussis) at 54th ICAAC
5. HRTTreatments / Natural Health Research Announces New Intuitive Online Hormone Test, Allowing Clients to Evaluate Possible Hormone Imbalances Easily Online
6. RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars
7. Worcester Polytechnic Institute Receives NIH Grant to Study Components of a Potentially Potent and Cost-Effective Malaria Treatment
8. Blue Horizon Stem Cell Treatment Helps Paralyzed Patient Regain Periods of Mobility
9. Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy
10. Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion
11. RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders
Post Your Comments:
(Date:10/13/2015)... ... October 13, 2015 , ... ... assessment of organotypic 3D cell culture models, has launched a 14 Day ... their patent-pending 3D InSight™ Human Liver Microtissues. The service streamlines toxicity testing ...
(Date:10/13/2015)... 13, 2015 " Microbiology Culture Market ... - 2023 " , the global microbiology culture ... to reach US$7.59 bn by 2023, expanding at a CAGR of ... " Microbiology Culture Market - Global Industry Analysis, Size, ... , the global microbiology culture market was valued at US$4.51 ...
(Date:10/13/2015)... October 13, 2015      Q ... company, has entered into a strategic relationship with Wombat ... and Paris, France based strategic ... --> This collaborative arrangement gives Q BioMed ... advisory team as well as long established pharmaceutical industry ...
(Date:10/13/2015)... ... 13, 2015 , ... Exotic Automation & Supply , ... components, is opening its latest Parker Store retail location in Ann, Arbor, MI. ... major expansion in Metropolitan Detroit in less than a year. The Ann Arbor ...
Breaking Biology Technology:
(Date:10/8/2015)... , October 8, 2015 ... or the "Company"), a biometric authentication company focused ... of the Wocket® smart wallet announces that revenues ... were approximately $410,000 compared with $113,00 for the ... the 9 months ended September 30, 2015 were ...
(Date:10/5/2015)... 2015 ) ... Inc. (NASDAQ: NXTD ), a biometric authentication company ... ) releases the following market ... ), a biometric authentication company focused on the growing ... ( ) releases the following market ...
(Date:9/30/2015)... YORK , Sept. 30, 2015  The global glucose ... billion for 2015. So says a new report on the ... diabetes management segment dominate the market, followed by continuous glucose ... publisher. Kalorama reports on the market for these products in its ... ...
Breaking Biology News(10 mins):