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Transposagen Expands Field of Use for piggyBac Technology
Date:10/15/2009

LEXINGTON, Ky., Oct. 15 /PRNewswire/ -- Transposagen Biopharmaceuticals, Inc. based in Lexington, KY announced today that it has come to an agreement to expand its license for piggyBac technology to cover nearly all commercial applications. The intellectual property, owned jointly by the University of Notre Dame, the University of Florida and the United States Department of Agriculture, enables facile genetic manipulation of most species. It is the core technology used by Transposagen to create TKO(TM) Knockout Rat Models, laboratory rats with a single gene disruption that mimic human disease.

The laboratory of Dr. Malcolm J. Fraser, Jr. at the University of Notre Dame has been responsible for the early characterization and development of the piggyBac DNA transposon. PiggyBac is a highly versatile technology that is used for genetic engineering in almost any animal, allowing for both mutagenesis (changing or disrupting genes) and transgenesis (adding genes). PiggyBac is now enabling genetic manipulation for a wide range of important species including research animals and agriculturally important animals for which genetic manipulation was previously impossible or cost-prohibitive.

"Transposagen was already in the process of using piggyBac to generate tens of thousands of knockout rat lines in a very short period of time. We will now be able to use piggyBac to modify the genomes of other important organisms," said Dr. Eric Ostertag, CEO of Transposagen Biopharmaceuticals, Inc. "PiggyBac is also finding uses in human therapeutics as it can be used to
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SOURCE Transposagen Biopharmaceuticals, Inc.
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