Navigation Links
Transposagen Creates a Rat Model of the Human Immune System
Date:8/6/2009

LEXINGTON, Ky., Aug. 6 /PRNewswire/ -- Transposagen Biopharmaceuticals, Inc. based in Lexington, KY announced today that its scientists and collaborators from the Medical College of Wisconsin have created and characterized the world's first rat model of severe combined immunodeficiency, or SCID. The Transposagen rat has a nearly complete lack of the major components of the immune system. Transposagen will be marketing SCID rats to pharmaceutical and biotechnology companies. "Transposagen is pleased to have characterized the world's first rat model of SCID. We now have intellectual property covering the SCID phenotype in rat and will be offering the SCID rat and other rat models of the immune system in the near future," said Dr. Eric Ostertag, CEO of Transposagen.

SCID can also affect humans, such as the "Bubble Boy," who had to live inside of a sterile environment to reduce the likelihood of contracting a fatal infection. The SCID mouse has been one of the most often used animal models in the history of drug discovery and development research. Transposagen's SCID rats are characterized by a deficiency of T-cells, B-cells and NK-cells, some of the white blood cells necessary to prevent invasive bacteria and viruses from causing serious disease. "This new immune deficiency rat model cannot reject transplanted tissues, even from other species, and will be especially important in cancer and transplantation research," said Dr. Ostertag.

Rat models are superior to mouse models for testing the pharmacodynamics and toxicity of potential therapeutic compounds. This is partially because the number and type of many of the rat's detoxifying enzymes are very similar to those in humans. Rats are also better models than mice for specific disease categ
'/>"/>

SOURCE Transposagen Biopharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Laser technology creates new forms of metal and enhances aircraft performance
2. ParagonRx Creates New Website Featuring REMS Help Center for Pharma
3. A Global View: NanoLogix Creates Science Advisory Board
4. GSK and Pfizer Innovative Agreement Creates Specialist HIV Company
5. Pathway for Biosimilars Act Protects Patients, Promotes Competition, Preserves Innovation and Creates Quality Jobs, Lilly Says
6. MRI Expands Energy Role: Launches Center for Integrated Algal Research and Creates Director of Energy Programs Position
7. New process creates 3-D nanostructures with magnetic materials
8. Monsantos Industry-Leading Seed Position Creates Accelerated Biotech Trait Opportunity in Latin America
9. Inclinix Expansion Creates New Position and Promotions
10. CryoPort Creates Personal Wall on Wallst.nets Financial Social Community, my.wallst.net
11. ADVENTRX Creates Executive Vice President Position and Announces New Chief Financial Officer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/14/2014)... Communications, a leading provider of strategic communications services to corporations and ... the United States and Europe ... JD, is returning to the firm,s Washington, D.C. ... more than two years of service as Associate Commissioner for the ...
(Date:1/14/2014)... The largest international professional organization of scientists ... derivatives thereof has endorsed an educational program that ... challenges of adulterated herb and botanical products. ... The Society for Medicinal Plant and Natural Product ...
(Date:1/14/2014)... January 14, 2014 In recent years, ... and methods in product development and promotion has led ... This mistrust, fueled by concerns about the insidious impact ... reports of spectacular fines to the world’s biggest pharmas ...
(Date:1/14/2014)... Ontario , Jan. 14, 2014   Kinaxis ®, provider ... SCM ) and sales and operations planning ( S&OP ) ... Biomanufacturing Summit , which will be held at the ... the conference, join Kinaxis customer Elisabeth Kaszas , Director ...
Breaking Biology Technology:Former FDA Associate Commissioner Returns To 3D Communications 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... , , FREMONT, Calif., Dec. 16 WaferGen Biosystems, ... state-of-the-art genetic analysis systems, today announced that it will ... service for gene-expression profiling using its SmartChip(TM) Real-Time PCR ... comprehensive human microRNA panel of 885 microRNAs on a ...
... ... , ... (Vocus) December 16, 2009 -- Scientists at the U.S. Department of Energy’s (DOE) Argonne ... microgears when suspended in a solution, providing insights for design of bio-inspired dynamically adaptive ...
... , INDIANAPOLIS, Dec. 16 /PRNewswire/ ... Indiana,s life sciences industry and an active venture capital market, ... Retirement Fund, Indiana University, Purdue University, the University of Notre ... the establishment of the INext Fund, a $58 million venture ...
Cached Biology Technology:WaferGen to Launch Human MicroRNA Panel for Gene-Expression Profiling of 885 MicroRNA for Its Service Using the SmartChip(TM) Real-Time PCR System 2WaferGen to Launch Human MicroRNA Panel for Gene-Expression Profiling of 885 MicroRNA for Its Service Using the SmartChip(TM) Real-Time PCR System 3WaferGen to Launch Human MicroRNA Panel for Gene-Expression Profiling of 885 MicroRNA for Its Service Using the SmartChip(TM) Real-Time PCR System 4Argonne Scientists Use Bacteria to Power Simple Machines 2Argonne Scientists Use Bacteria to Power Simple Machines 3Indiana Industry, University and Community Leaders Capitalize on Next Generation of State's Life Sciences Growth 2Indiana Industry, University and Community Leaders Capitalize on Next Generation of State's Life Sciences Growth 3Indiana Industry, University and Community Leaders Capitalize on Next Generation of State's Life Sciences Growth 4Indiana Industry, University and Community Leaders Capitalize on Next Generation of State's Life Sciences Growth 5
(Date:4/23/2014)... New University of Toronto Scarborough research shows that male ... well-fed virgins a rare example of mate preference ... by UTSC post-doc Emily MacLeod and Maydianne Andrade, a ... both controlled field studies and the wild that males ... also found male black widows can tell whether a ...
(Date:4/23/2014)... (4/23/14) -- Researchers have found evidence of an ... that increase aggressive behavior in children, especially in ... all children exposed to prenatal smoking will have ... not," said Brian Boutwell, Assistant Professor at Sam ... senior author on the study. "One possible ...
(Date:4/23/2014)... announced Sophie Martin of the University of Lausanne, Switzerland, ... The award acknowledges her work to understand the molecular ... cell. , Martin has been working for the past ... way in which the spatial organization of cells contributes ... 11 years, she has been using fission yeast, which ...
Breaking Biology News(10 mins):Picky male black widow spiders prefer well-fed virgins 2Genetics risk, prenatal smoking may predict behavioral problems 2EMBO Gold Medal 2014 awarded to Sophie Martin 2
... eating fatty and sugary foods causes chemical changes in the ... to going through drug withdrawal, according to a study published ... Faculty of Medicine and its affiliated CRCHUM Hospital Research Centre. ... comparable to our own, we discovered that the neurochemistry of ...
... DEC. 10, 2012 Joanna Lambert, professor in the UTSA ... the American Association for the Advancement of Science (AAAS) ... field of primate feeding biology at evolutionary and ecological ... selected for her scientifically or socially distinguished efforts to ...
... natural plant dye once prized throughout the Old World to make ... basis for a new "green" battery. Chemists from ... University and the U.S. Army Research Laboratory to develop a non-toxic ... the roots of the madder plant ( Rubia species). ...
Cached Biology News:Could ending your fatty food habit cause withdrawal symptoms and depression? 2UTSA anthropologist honored for contributions researching primates in Africa 2Ancient red dye powers new 'green' battery 2Ancient red dye powers new 'green' battery 3
... buffered anti-freeze environment for enzyme conjugated antibodies ... low viscosity solution at -20C , ... sampling is convenient , Contains preservatives ... Protect enzyme conjugates during storage without ...
Request Info...
... on a new flow-through technology, automates all of ... of tissues on microscope slide formats. ... expression, in situ hybridization (ISH) localizes transcripts in ... to validate and confirm results obtained by in ...
... The Microarray Gene Frame® has been ... These frames feature the same dual ... Gene Frame® range for easy removal ... uniformity and there are three sizes ...
Biology Products: