Navigation Links
Transplanted cells may hold the key to curing hemophilia A, Einstein scientists report
Date:2/14/2008

Scientists at the Albert Einstein College of Medicine of Yeshiva University have shown for the first time that transplanted cells can cure hemophilia A (the most common form of the disease) in an animal model. Their study appears online February 14 in the Journal of Clinical Investigation.

Hemophilia A affects one in 10,000 males and is characterized by recurrent, spontaneous bleeding that can cause disability or death. It has, most famously, affected British and Russian nobility, along with countless others. The Einstein team, led by Dr. Sanjeev Gupta, cured hemophilia A by transplanting healthy liver endothelial cells from donor mice into a mouse model of the disease. In curing these mice, the Einstein researchers also overturned conventional wisdom regarding which cells produce factor VIII, the crucial clotting protein that is lacking in people with type A hemophilia.

Weve known for three decades that factor VIII is produced in the liver, but precisely where has been controversial, says Dr. Gupta, a professor in the departments of medicine and pathology at Einstein. It was assumed that factor VIII was made by the hepatocytescells that perform many of the livers functions and comprise most of its bulk. But our research had suggested that the primary sources were special endothelial cells that line the sinusoids, the livers blood-filled spaces. We did this study to confirm the role of liver endothelial cells in producing factor VIII and to see if transplanting them from a healthy donor liver could correct hemophilia A in an animal model.

The donor mice used by Dr. Guptas team had been genetically engineered so that their endothelial cells expressed the gene for green fluorescent protein. This allowed the researchers to see whether the liver endothelial cellsisolated from donor livers and then injected into a vein leading into the liver of recipient hemophilia A micecould successfully engraft within the recipients livers. Before tran
'/>"/>

Contact: Karen Gardner
kgardner@aecom.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

Page: 1 2

Related biology technology :

1. ARIUS presents new findings showing therapeutic antibody inhibits human leukemic cancer stem cells
2. CORD:USE Cord Blood Bank Announces the Addition of Dr. John Wagner, a Pioneer in the Use of Umbilical Cord Blood Stem Cells, to Its Scientific Advisory Board
3. Historic Breakthrough in Fighting Childrens Batten Disease as China Stem Cells Give New Lease on Life to 6 Year Old California Boy
4. Stemagen First to Create Cloned Human Embryos From Adult Cells
5. Researchers use magnetism to target cells to animal arteries
6. Solar cells of the future
7. New use for stem cells found in war on terrorism
8. UW-Madison scientists guide human skin cells to embryonic state
9. Shinya Yamanaka reprograms human adult cells
10. Discovery Institute Bioethicist Lauds Breakthrough in Stem Cells Research that Eliminates Need for Human Cloning
11. STEM CELLS Journal Names Co-Editors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... Quebec , November 21, 2014 ... como responsable comercial   Mariano Rodríguez es ...   KLOX está en marcha para comenzar ... de cura de heridas de reciente aprobación en Europa   ... "la compañía") se complace al anunciar los siguientes nombramientos: ...
(Date:11/21/2014)... Author Matthew J. Pallamary’s second short story ... published as a tribute to his mentor Ray ... Story” category of the 2014 USA Best Book ... USA Book News, said this year’s contest yielded over ... & Schuster, Penguin, John Wiley & Sons, Houghton Mifflin ...
(Date:11/21/2014)... 2014 BlueInGreen, LLC ( BlueInGreen® ... (Pinnacle), and PCI, Inc., leading suppliers of ozone ... been selected to provide a new state-of-the-art ozone ... R. Noland Wastewater Treatment. The new ozone ... gas dissolution technology, Pinnacle Ozone’s industry leading ...
(Date:11/21/2014)... Nov. 20, 2014 Polaris Group announced ... in its Phase 1 trial of ADI-PEG 20 ... treatment of malignant pleural mesothelioma (MPM) and non-squamous ... clinical trials on ADI-PEG 20, both as monotherapy ... treatment of several other indications, including breast cancer, ...
Breaking Biology Technology:KLOX Technologies anuncia sus nombramientos ejecutivos 2KLOX Technologies anuncia sus nombramientos ejecutivos 3KLOX Technologies anuncia sus nombramientos ejecutivos 4KLOX Technologies anuncia sus nombramientos ejecutivos 5Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 2Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 4City of Fayetteville Leads Nation with Innovative Ozone Technology 2City of Fayetteville Leads Nation with Innovative Ozone Technology 3City of Fayetteville Leads Nation with Innovative Ozone Technology 4Polaris Group Announces Treatment of First Patient in Phase 1 Study of ADI-PEG 20 plus Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma And Non-Squamous Non-Small Cell Lung Carcinoma 2
... Regenicin™, Inc. (OTC Bulletin Board: ... that John J. Weber, the former highest ranking American ... USA"), has agreed to join the company as a ... Financial Officer.  Weber brings over 20 years of medical-related ...
... biomedical company advancing DNA-Guided Medicine, has been awarded ... Predicting Clinical Outcomes of Treatment in Patients ... Andreas Windemuth, Ph.D., Chief Technology Officer and ... has been successfully applied to several psychiatric and ...
... , Inc. (Nasdaq: GHDX ) today announced that ... conferences in September: Dean Schorno , ... Nicolaus Healthcare Conference 2010 on Friday, September 17 at 11:30 ... Genomic Health,s Chief Operating Officer and Chief Financial Officer, will ...
Cached Biology Technology:Former Fujifilm Medical Systems USA Executive John J. Weber Agrees to Join Regenicin™ as a Member of Its Board of Directors and Interim CFO 2Genomas Awarded US Patent for its PhyzioGenomics Platform Technology to Predict Treatment Responses 2Genomic Health to Present at Two Upcoming Investor Conferences 2
(Date:11/18/2014)... NEW YORK , Nov. 18, 2014 /PRNewswire/ ... iris-based identity authentication solutions, and MorphoTrust USA ... solutions and services, today announced a strategic partnership ... across enterprise, motor vehicle administration (MVA), airport screening ... leader in identity-related solutions, MorphoTrust serves consumers through ...
(Date:11/11/2014)... 2014  Forensicon, Inc., a Chicago ... announce the promotion of Yaniv Schiff from ... In Schiff,s new role as Director, he will lead ... forensics examiners and provide leadership within the company,s digital ... http://photos.prnewswire.com/prnh/20141110/157719 Schiff joined Forensicon in ...
(Date:11/7/2014)... Nov. 7, 2014  In conjunction with the ... Departments, The Community Foundation of the Verdugos has announced the ... JUSTICE PROJECT," a $250,000 initiative to keep the Verdugo Regional ... its first six months of existence, the Lab has processed ... for local law enforcement. "Because our number one ...
Breaking Biology News(10 mins):EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2
... --- How do the French get away with a clean ... fats? Scientists have long suspected that the answer to the ... of a new study bring them closer to understanding why. ... Public Library of Science (PLoS) ONE, researchers from industry and ...
... York next week to discuss new approaches to one ... weather. Five years ago, Professor Peter Bernath, of ... the Atmospheric Chemistry Experiment (ACE) satellite mission. To ... University at the King,s Manor in York will review ...
... release is available in German . ... cormorants in order to reconcile nature conservation and fishing ... work at the European level, researchers from the Helmholtz ... journal Environmental Conservation. Furthermore, they suggest a five-step action ...
Cached Biology News:Substance in red wine found to keep hearts young 2Substance in red wine found to keep hearts young 3York symposium puts focus on chemical 'weather' 2The cormorant -- the 'black plague' or an example of successful species conservation? 2The cormorant -- the 'black plague' or an example of successful species conservation? 3The cormorant -- the 'black plague' or an example of successful species conservation? 4The cormorant -- the 'black plague' or an example of successful species conservation? 5
... cell and PowerPac basic power supply are used ... in agarose gels. The mini format cell includes ... and leveling bubble. The PowerPac basic power supply, ... V, 4-400 mA, and 75 W. Power cord ...
... The Sequi-Gen GT and PowerPac 3000 system, ... using a 38 x 30 cm vertical slab ... GT electrophoresis cell, which is capable of separating ... an integral plate chamber (IPC) assembly (IPC and ...
... Paragon CZE 2000 Capillary Electrophoresis System ... serum protein electrophoresis (SPE), urine protein ... fast and accurate analysis. The system ... sample preparation and no staining to ...
The filter 640DF35 for the Molecular Imager FX is a band pass filter for Texas Red dye....
Biology Products: