Navigation Links
Transplanted brain cells in monkeys light up personalized therapy
Date:3/14/2013

ny cell in the body. iPS cells, however, derive from adult cells rather than embryos.

In the lab, the iPS cells were converted into neural progenitor cells. These intermediate-stage cells can further specialize into the neurons that carry nerve signals, and the glial cells that perform many support and nutritional functions. This final stage of maturation occurred inside the monkey.

Zhang, who was the first in the world to derive neural cells from embryonic stem cells and then iPS cells, says one key to success was precise control over the development process. "We differentiate the stem cells only into neural cells. It would not work to transplant a cell population contaminated by non-neural cells."

Another positive sign was the absence of any signs of cancer, says Zhang a worrisome potential outcome of stem cell transplants. "Their appearance is normal, and we also used antibodies that mark cells that are dividing rapidly, as cancer cells are, and we do not see that. And when you look at what the cells have become, they become neurons with long axons [conducting fibers], as we'd expect. They also produce oligodendrocytes that are helping build insulating myelin sheaths for neurons, as they should. That means they have matured correctly, and are not cancerous."

The experiment was designed as a proof of principle, says Zhang, who leads a group pioneering the use of iPS cells at the Waisman Center on the UW-Madison campus. The researchers did not transplant enough neurons to replace the dopamine-making cells in the brain, and the animal's behavior did not improve.

Although promising, the transplant technique is a long way from the clinic, Zhang adds. "Unfortunately, this technique cannot be used to help patients until a number of questions are answered: Can this transplant improve the symptoms? Is it safe? Six months is not long enough And what are the side effects? You may improve some symptoms, but if that leads to som
'/>"/>

Contact: Su-Chun Zhang
szhang4@wisc.edu
608-265-2543
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Stem Cells Show Promise in Extending Transplanted Kidneys’ Survival Time
2. Magnet helps target transplanted iron-loaded cells to key areas of heart
3. NSBRI Funds Cerebrotech to Accelerate Development of Brain Monitoring Device
4. Study: Brain Imaging After Mild Head Injury/Concussion Can Show Lesions
5. Enhanced brain acetate metabolism may reward heavy drinkers
6. Ectopic eyes function without connection to brain
7. Blueprint for an artificial brain
8. Amarantus BioScience and Banyan Biomarkers to Present Poster of MANF Data at The 3rd Annual Traumatic Brain Injury Conference
9. Brain Research Foundation 2013 Scientific Innovations Awards To Dr. Jean Hebert and Dr. Brian Litt
10. Society for Brain Mapping and Therapeutics endorse President Obamas support for Human Brain Mapping research; nominating him for prestigious Pioneer in Healthcare Policy Award
11. Fighting disease deep inside the brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... ... September 01, 2015 , ... Knowledgent , the data and analytics ... advanced analytics utilizing data lakes in the healthcare industry. , As the Internet of ... of data over the last few years as more entities become technology enabled through ...
(Date:9/1/2015)... ... 2015 , ... Industry leader iLab Solutions recently announced Gerard ... position, Gibbs will lead iLab’s business operations in the region, with an emphasis ... not only introducing iLab to potential partners but support and management of accounts ...
(Date:9/1/2015)... CA (PRWEB) , ... September 01, 2015 , ... ... and colleagues from University of California Los Angeles, Boston University School of Medicine, ... Prevention appears in PLOS One, the world’s first multidisciplinary Open Access journal. ...
(Date:9/1/2015)... Shire plc (LSE: SHP, NASDAQ: SHPG ) announces ... of Directors as a Non-Executive Director. Sara will also be ... the Shire Board. Both appointments will be effective as of ... President and Chief Executive Officer of Dun & Bradstreet, Inc. ... D&B, she helped drive the transformation of the company from ...
Breaking Biology Technology:New White Paper Explores Data Lake Opportunities in the Healthcare Industry 2iLab Solutions Hires Gerard Gibbs, Director of Business Development, Asia Pacific 2iLab Solutions Hires Gerard Gibbs, Director of Business Development, Asia Pacific 3Synedgen’s Director for Pharmaceutical Manufacturing Publishes New Research 2Synedgen’s Director for Pharmaceutical Manufacturing Publishes New Research 3Shire Appoints Sara Mathew to Board of Directors 2
... , PLYMOUTH MEETING, Pa., Oct. 30 /PRNewswire-Asia-FirstCall/ -- ... announced,it will participate in the following conferences: , , ... 2009 at the Waldorf=Astoria hotel in New ... at 3:20 pm ET on Tuesday, November 3, and meet with, ...
... drug, LX211 (LUVENIQ; oral voclosporin), may become the first ... uveitis, a group of serious eye conditions inevitably associated ... steroid use. Results of international Phase 2/3 clinical trials ... two podium presentations at the American Association of Ophthalmology ...
... 2009 Very tiny wires, called nanowires, made from such ... role as electrical or mechanical switches in the development ... require a deep understanding of how these and other ... their resultant strengths and weaknesses. How mechanical properties ...
Cached Biology Technology:BMP Sunstone Announces November Investor Conference Participation 2LX211 highlighted as potential disease modifying therapy for noninfectious uveitis 2LX211 highlighted as potential disease modifying therapy for noninfectious uveitis 3LANL Roadrunner simulates nanoscale material failure 2
(Date:8/19/2015)... HAUPPAUGE, N.Y. , Aug. 19, 2015 /PRNewswire/ ... announced that it has entered into a Definitive ... intellectual property, of iris authentication market leader EyeLock ... transaction, VOXX will have a controlling interest in ... is subject to completion of due diligence.  Expanding ...
(Date:8/12/2015)... Minn. , Aug. 12, 2015   MedNet ... supports the entire spectrum of clinical research, is proud ... , the company,s comprehensive SaaS-based eClinical technology platform, has ... during the first two quarters of 2015.   Q2 ... second largest quarters measured by contract value sold in ...
(Date:8/11/2015)... , August 11, 2015 Today, ZUK ... Already received as well as expected revenues in 2015 that relate ... FPC,s communicated revenue guidance of approximately 2,200 MSEK for 2015. ... is a prominent smartphone manufacturer in ... ZUK selected FPC1 155 for ...
Breaking Biology News(10 mins):VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 2VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 3VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 4VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 5MedNet Solutions Experiences Explosive Corporate Growth 2FPC's Touch Fingerprint Sensor FPC1155 in ZUK's Smartphone Z1 2
... More than 2,000 years after Archimedes found a way to ... mass in two different fluids, MIT scientists have used the ... to measure the density of a single cell. "Density ... Grover, a research associate in MIT,s Department of Biological Engineering. ...
... 21, 2011) -- The U.S. Department of Defense (DOD) ... of Engineering researchers for high-tech, specialized measuring equipment that ... engineering applications. The University of Arizona captured five of ... Engineering awardees are Armin Sorooshian of the Department of ...
... Richmond, Va. (June 20, 2011) Researchers at ... mechanisms in mitochondria that have implications for cancer as ... disease, heart disease and hypertension. This discovery has pioneered ... research ripe with possibilities of developing future gene therapies ...
Cached Biology News:How dense is a cell? 2How dense is a cell? 3UA engineering college lands national support for equipment used in unique research 2Discoveries in mitochondria open new field of cancer research 2
... sets a new standard for high performance ... new design in instrumentation, this easy-to-use benchtop ... The BD FACSAria instrument is the first ... flow cell. This new flow cell ...
Mouse monoclonal antibody raised against a partial recombinant COG2. NCBI Entrez Gene ID = COG2...
Mouse polyclonal antibody raised against a partial recombinant IFNA13. NCBI Entrez Gene ID = 3447...
Mouse monoclonal antibody raised against a full length recombinant LDB3. NCBI Entrez Gene ID = LDB3...
Biology Products: