Navigation Links
Transplanted brain cells in monkeys light up personalized therapy
Date:3/14/2013

ny cell in the body. iPS cells, however, derive from adult cells rather than embryos.

In the lab, the iPS cells were converted into neural progenitor cells. These intermediate-stage cells can further specialize into the neurons that carry nerve signals, and the glial cells that perform many support and nutritional functions. This final stage of maturation occurred inside the monkey.

Zhang, who was the first in the world to derive neural cells from embryonic stem cells and then iPS cells, says one key to success was precise control over the development process. "We differentiate the stem cells only into neural cells. It would not work to transplant a cell population contaminated by non-neural cells."

Another positive sign was the absence of any signs of cancer, says Zhang a worrisome potential outcome of stem cell transplants. "Their appearance is normal, and we also used antibodies that mark cells that are dividing rapidly, as cancer cells are, and we do not see that. And when you look at what the cells have become, they become neurons with long axons [conducting fibers], as we'd expect. They also produce oligodendrocytes that are helping build insulating myelin sheaths for neurons, as they should. That means they have matured correctly, and are not cancerous."

The experiment was designed as a proof of principle, says Zhang, who leads a group pioneering the use of iPS cells at the Waisman Center on the UW-Madison campus. The researchers did not transplant enough neurons to replace the dopamine-making cells in the brain, and the animal's behavior did not improve.

Although promising, the transplant technique is a long way from the clinic, Zhang adds. "Unfortunately, this technique cannot be used to help patients until a number of questions are answered: Can this transplant improve the symptoms? Is it safe? Six months is not long enough And what are the side effects? You may improve some symptoms, but if that leads to som
'/>"/>

Contact: Su-Chun Zhang
szhang4@wisc.edu
608-265-2543
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Stem Cells Show Promise in Extending Transplanted Kidneys’ Survival Time
2. Magnet helps target transplanted iron-loaded cells to key areas of heart
3. NSBRI Funds Cerebrotech to Accelerate Development of Brain Monitoring Device
4. Study: Brain Imaging After Mild Head Injury/Concussion Can Show Lesions
5. Enhanced brain acetate metabolism may reward heavy drinkers
6. Ectopic eyes function without connection to brain
7. Blueprint for an artificial brain
8. Amarantus BioScience and Banyan Biomarkers to Present Poster of MANF Data at The 3rd Annual Traumatic Brain Injury Conference
9. Brain Research Foundation 2013 Scientific Innovations Awards To Dr. Jean Hebert and Dr. Brian Litt
10. Society for Brain Mapping and Therapeutics endorse President Obamas support for Human Brain Mapping research; nominating him for prestigious Pioneer in Healthcare Policy Award
11. Fighting disease deep inside the brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... Arizona (PRWEB) January 15, 2014 2013 ... for Scottsdale’s Brain State Technologies®. They saw continued independent ... Medical Center who were awarded a $1 million grant ... published in “Brain and Behavior” a peer reviewed journal, ...
(Date:1/14/2014)... 14, 2014 Carahsoft and CDS Federal ... 23, 2014 at 2pm EST (11am PST), “Natural Language ... focuses on how technology can turn raw, heterogeneous data ... government agencies. The online webinar will last approximately one ...
(Date:1/14/2014)... 2014 The largest international professional organization of ... therapeutic derivatives thereof has endorsed an educational program ... the challenges of adulterated herb and botanical products. ... The Society for Medicinal Plant and Natural ...
(Date:1/14/2014)... 14, 2014 Global Record Systems, ... information technology solutions for patients, physicians, the biopharmaceutical ... announced today the signing of a three-year Research ... Drug Administration (FDA). This initiative is designed ...
Breaking Biology Technology:Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2
... vision affects 3.3 million Americans age 40 and over, ... to reach 5.5 million by the year 2020, according ... of Ophthalmology . , ,Because of an aging population, ... diseases responsible for blindness such as age-related macular degeneration, ...
... in ePrairie reviewed the top 100 most wired hospitals in ... the top 100. While this is a sign of progress ... hospitals is U.S. News & World Report annual ... some very interesting results, and I have tried to cull ...
... seeking increased connectivity with their healthcare providers hope that ... and make services easier to access. Although the streamlining ... evolving piecemeal, a group of Wisconsin hospitals appears to ... ,The group, organized under Aurora Health Care , ...
Cached Biology Technology:Medical College given funds for eye research 2Midwest shines among best hospitals in U.S. 2Midwest shines among best hospitals in U.S. 3Midwest shines among best hospitals in U.S. 4Midwest shines among best hospitals in U.S. 5Midwest shines among best hospitals in U.S. 6Midwest shines among best hospitals in U.S. 7Midwest shines among best hospitals in U.S. 8Aurora ranks among most wired systems 2
(Date:4/24/2014)... A common plant puts out a welcome mat to bacteria ... mix. , The study published this week in the ... targets during the battle between microbe and host that researchers ... the humble and oft-studied plant Arabidopsis puts out ... It,s as if a hostile army were unknowingly passing by ...
(Date:4/23/2014)... German . Man ... difference between sexes depends on one single element of the genome: ... two sexual chromosomes are X and Y, whereas women have two ... morphological and physiological differences between males and females. , But this ... the X and Y were identical, until the Y started to ...
(Date:4/23/2014)... research shows that male black widow spiders prefer their ... example of mate preference by male spiders. ... and Maydianne Andrade, a professor in UTSC,s Department of ... the wild that males overwhelmingly chose to mate with ... can tell whether a potential mate is well-fed and ...
Breaking Biology News(10 mins):How a plant beckons the bacteria that will do it harm 2How a plant beckons the bacteria that will do it harm 3Male or female? 2Male or female? 3Picky male black widow spiders prefer well-fed virgins 2
... mutations in cancer patients to predict clinical outcome has ... decades, but now researchers at the Kimmel Cancer Center ... links cancer cell metabolism with poor clinical outcome. This ... of human cancer cell. The researchers demonstrate ...
... and demand for it is increasing all the time but ... more secure, thanks to research at The University of Nottingham,s ... the vanilla bean, the ,fruit, of the flowering vanilla orchid. ... ancient Central American civilisations such as the Aztecs and is ...
... is available in German . , Insects ... of odor molecules in the air are sufficient to be ... receptor proteins, expressed in these neurons recognize the odors. The ... electrical signals that are processed in the insect brain and ...
Cached Biology News:Jefferson researchers unlock key to personalized cancer medicine using tumor metabolism 2Jefferson researchers unlock key to personalized cancer medicine using tumor metabolism 3Preserving a world favorite flavour 2Molecular messages from the antennae 2
... SUPERaseIn RNase Inhibitor (patent pending) is a ... noncovalently binds and inhibits the most common ... C, 1 and T1. SUPERaseIn can be ... could be problematic. It is ideal for ...
... RNaseOUT Recombinant Ribonuclease Inhibitor ... of pancreatic-type ribonucleases such as ... inhibitors RNaseOUT Recombinant Ribonuclease Inhibitor ... a molecular weight ~52 kDa. ...
...
... Core Kit contains all the ... assays on a wide range ... to dNTPs, the Core Kit ... used BIOLASE DNA polymerase, which ...
Biology Products: