Navigation Links
Transgenomic Develops New Assays to Detect EGFR Mutations Using COLD-PCR
Date:11/8/2010

OMAHA, Neb., Nov. 8, 2010 /PRNewswire-FirstCall/ -- Transgenomic, Inc. (OTC Bulletin Board: TBIO) today announced completion of a development study of several new assays to detect genetic mutations using the Company's proprietary Co-amplification at Lower Denaturing Temperature PCR (COLD-PCR) technology in the Epidermal Growth Factor Receptor (EGFR) gene. EGFR mutations are found in a number of cancers, including lung and colorectal cancers.  Several new targeted cancer therapeutics called tyrosine kinase inhibitors (TKIs) have been approved or are in clinical trials to be used as front line or secondary therapies against these cancers. The presence of mutations in certain regions of the EGFR gene are key criteria to determine whether or not a patient should receive TKI inhibitor therapy.

In its study, Transgenomic looked at the ability of COLD-PCR to detect EGFR mutations in exons 19-21.  Study results indicate that the COLD-PCR assays detect all exon 19 deletions, the T790M mutation in exon 20 and all mutations in exon 21 in the specific regions amplified, including L858R and L861Q point mutations.  The sensitivity of detection when confirmed using Sanger sequencing is 0.05% to 0.2% using plasmid and cell line DNA dilutions.  Preliminary experiments on DNA isolated from plasma samples are currently underway, and early results are mimicking the plasmid and cell line DNA studies.  Transgenomic's assays were developed in collaboration with the Dana-Farber Cancer Institute and a major oncology pharmaceutical partner.

Craig Tuttle, Transgenomic CEO, commented, "One of our key corporate strategic initiatives is to develop ultra-high sensitivity assays for the detection of low-level DNA mutations in body fluids.  We believe COLD-PCR provides us with the analytical sensitivity and accuracy to achieve this goal.  We have always belie
'/>"/>

SOURCE Transgenomic, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Transgenomic Announces Partnership With Key Genomics for Ovarian Cancer Assay to Guide Therapeutic Options
2. Webcast Alert: Transgenomic Inc. Announces Third Quarter 2008 Earnings Release Conference Call Webcast
3. Transgenomic, Inc. Reports Third Quarter 2008 Results
4. Transgenomic to Present at Rodman & Renshaw 10th Annual Healthcare Conference
5. Transgenomic Awarded SBIR Grant to Support Development of SURVEYOR(R) Endonuclease Adaptor-ligated Libraries (SEAL) for Determining Whole Genome Sequence Variation
6. Transgenomic Signs Letter of Intent for an Agreement to Exclusive License With Option to Acquire Power3 Medical Products Neurodegenerative Diagnostics
7. Transgenomic Receives Accreditation From College of American Pathologists
8. Webcast Alert: Transgenomic Inc. Announces Fourth Quarter 2008 Earnings Release Conference Call Webcast
9. Webcast Alert Cancellation: Transgenomic Inc. Cancels Fourth Quarter 2008 Earnings Release Conference Call Webcast
10. Transgenomic Awarded Clinical Laboratory Certification in California
11. Reminder - Webcast Alert: Transgenomic Inc. Announces Fourth Quarter 2008 Earnings Release Conference Call Webcast
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... California (PRWEB) August 27, 2014 ... (LLNL), through Lawrence Livermore National Security LLC ... to develop and deliver a state-of-the-art laser system ... facility (ELI Beamlines), under construction in the Czech ... performance, the laser system, called the " High ...
(Date:8/27/2014)... is how plants survive impact by the huge ... while using this energy for photosynthesis. The hypothesis ... blades quickly dissipate the energy throughout the entire ... DTU Physics have now managed to successfully ,film, ... contain light-absorbing proteins which play a role in ...
(Date:8/27/2014)... , Aug. 27, 2014 ... the "Global Lactic Acid  (Biodegradable Polymer, Food ... Trends & Forecasts to 2019" report to ... simplest hydroxyl-carboxylic acid with an asymmetrical carbon atom. ... the biodegradable polymer, food and beverage, personal care ...
(Date:8/27/2014)... “We are honored to be named ... Thangaraj, CEO of Radiant Sage. “We are offering truly ... imaging corelab market to a different level. We ... to efficiently and effectively manage the massive amounts of ... analyzed and read by trained physicians. Being recognized by ...
Breaking Biology Technology:LLNL Synchs up with ELI Beamlines on Timing System 2LLNL Synchs up with ELI Beamlines on Timing System 3DTU researchers film protein quake for the first time 2Global Lactic Acid (Biodegradable Polymer, Food & Beverage, Personal Care & Pharmaceutical) Market - Trends & Forecasts to 2019 2Radiant Sage Named to CIOReview List of 100 Most Promising Technology Companies 2
... A small, external bioreactor holding human cells pumped out ... complications in a rat with acute inflammation caused by ... a report from researchers at the University of Pittsburgh ... Medicine. The findings were published today in the inaugural ...
... pool table with an unseen groove or bump that sends ... the same goes at the nano-scale, where the "billiard balls" ... semiconductor gallium arsenide. These tiny billiard tables are of ... research paper titled "The Impact of Small-Angle Scattering on Ballistic ...
... ROCHESTER, N.Y., May 14, 2012  More than one billion people ... natural decrease in the ability of the lens in the ... We,ve all seen others struggle with trying to read menus ... To combat this change in vision, which often begins ...
Cached Biology Technology:Bio-hybrid device acts as 'thermostat' to control systemic inflammation in sepsis 2You can't play nano-billiards on a bumpy table 2New Daily Disposable Multifocal Contact Lenses from CooperVision Offer Comfort, Performance, Health, and Convenience to Fit Your Life 2New Daily Disposable Multifocal Contact Lenses from CooperVision Offer Comfort, Performance, Health, and Convenience to Fit Your Life 3
(Date:8/27/2014)... piglets can be weaned later with no negative effects ... study at the University,s Roseworthy campus, published in the ... finding for pig producers. It allows improvements in piglet ... don,t usually start their oestrous cycles again during lactation, ... weaned," says Ms Alice Weaver, PhD candidate with the ...
(Date:8/27/2014)... Warwick research finds , Gamblers show the same ... research has shown. , Researchers, led by Dr Elliot ... conducted tests that found that both human gamblers and ... than low-value rewards. , Published in Biology Letters ... the important role that memories of previous biggest wins ...
(Date:8/26/2014)... over a colony of harmful bacteria, biofilms make ... protected in a biofilm pose a significant health ... to treatment, and biofilm-protected bacteria account for some ... and are 50 to 1,000 times more resistant ... essence, we may have stumbled onto a magic ...
Breaking Biology News(10 mins):Piglet weaning age no bar to litter frequency 2Gamblers are greedy bird-brains, University of Warwick research finds 2Breakthrough antibacterial approach could resolve serious skin infections 2Breakthrough antibacterial approach could resolve serious skin infections 3
... A total of 697.3 million board feet of softwood logs ... data released by the U.S. Forest Service,s Pacific Northwest Research ... total of 344.2 million board feet of softwood lumber. ... percent from the 2008 volume of 776.3 million board feet, ...
... ... ... ... , ...
... to detect nuclear explosions and enforce the world,s nuclear ... volcanoes in the Northern Mariana Islands near Guam. The ... for forward deployment of U.S. military forces in the ... U.S. Geological Survey and Southern Methodist University in Dallas ...
Cached Biology News:Log exports down, lumber exports up in Washington and Oregon in 2009 2Aware, Inc. Joins HIMSS10 Interoperability Showcase to Demonstrate Standards-Based Medical Image Sharing 2Aware, Inc. Joins HIMSS10 Interoperability Showcase to Demonstrate Standards-Based Medical Image Sharing 3Aware, Inc. Joins HIMSS10 Interoperability Showcase to Demonstrate Standards-Based Medical Image Sharing 4Aware, Inc. Joins HIMSS10 Interoperability Showcase to Demonstrate Standards-Based Medical Image Sharing 5Aware, Inc. Joins HIMSS10 Interoperability Showcase to Demonstrate Standards-Based Medical Image Sharing 6Volcano monitoring will target hazard threat to Marianas, US military and commercial jets 2Volcano monitoring will target hazard threat to Marianas, US military and commercial jets 3Volcano monitoring will target hazard threat to Marianas, US military and commercial jets 4
The DNA DipStick Kit is ideal for estimating nucleic acid concentrations and approximate yields. Works with ss- and ds-DNA, RNA, and oligonucleotides at concentrations as low as 0.1 ng/l....
Tris-Hepes kit of BG-163 & BG-165 (order number BG-166)...
... Immunogen: Synthetic peptide derived from ... WNT1 protein. Specificity: Reacts with ... Reactivity: Human Mouse (positive controls: ... cell lysates and mouse Mouse-1 cell ...
... The new StrepMAB-Immo coated microplates can ... immobilization of SerAla-Strep-tag II fusion proteins for ... Also small amounts of such proteins are ... (see graphic on the left) and will ...
Biology Products: