Navigation Links
Transgenomic Announces Discovery of a Novel Technique Which Enhances Analytic Sensitivity of Standard Sanger Sequencing to 1%
Date:3/29/2011

Sequencing protocol, we have shown we can identify mutations in samples with a mutant to wild-type ratio of 1:100.  We have also shown that BLOCker-Sequencing can discriminate different viral strains which co-elute using DHPLC.  The studies we have performed to date prove that BLOCker-Sequencing is a pivotal methodology for enhancing the mutation detection capabilities of Sanger Sequencing to levels equal to or better than commercially available allele-specific, pyrosequencing and next generation sequencing methods."

Craig Tuttle, Chief Executive Officer and President of Transgenomic commented, "BLOCker-Sequencing is a very exciting discovery.   Our studies have shown that BLOCker-Sequencing will provide a key enhancement to standard Sanger Sequencing.  It extends the utility of using Sanger Sequencing to easily and sensitively measure somatic mutations in cancer similar to how it is used in other areas of diagnostic medicine to measure germ line mutations.  In addition, BLOCker-Sequencing can be combined with our COLD-PCR technologies to provide ultra-sensitive DNA mutation detection allowing us to look for DNA mutations in a patient's blood sample rather than requiring a tumor sample.  Offering a BLOCker-Sequencing and COLD-PCR kit will extend the ability of labs to employ our combined technology for ultra-sensitive mutation detection using equipment and techniques they already have and are widely accepted by regulatory agencies worldwide as the gold standard for mutation detection.  We believe BLOCker-Sequencing coupled with COLD-PCR could revolutionize mutation detection assay technology."

A provisional patent for this new discovery has been filed in the United States.

About Transgenomic, Inc.

Transgenomic, Inc. (www.transgenomic.com) is a global biotechnology company specializing in high sensitivity genetic variation and mutation analysis, pr
'/>"/>

SOURCE Transgenomic, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Transgenomic Announces Partnership With Key Genomics for Ovarian Cancer Assay to Guide Therapeutic Options
2. Webcast Alert: Transgenomic Inc. Announces Third Quarter 2008 Earnings Release Conference Call Webcast
3. Transgenomic, Inc. Reports Third Quarter 2008 Results
4. Transgenomic to Present at Rodman & Renshaw 10th Annual Healthcare Conference
5. Transgenomic Awarded SBIR Grant to Support Development of SURVEYOR(R) Endonuclease Adaptor-ligated Libraries (SEAL) for Determining Whole Genome Sequence Variation
6. Transgenomic Signs Letter of Intent for an Agreement to Exclusive License With Option to Acquire Power3 Medical Products Neurodegenerative Diagnostics
7. Transgenomic Receives Accreditation From College of American Pathologists
8. Webcast Alert: Transgenomic Inc. Announces Fourth Quarter 2008 Earnings Release Conference Call Webcast
9. Webcast Alert Cancellation: Transgenomic Inc. Cancels Fourth Quarter 2008 Earnings Release Conference Call Webcast
10. Transgenomic Awarded Clinical Laboratory Certification in California
11. Reminder - Webcast Alert: Transgenomic Inc. Announces Fourth Quarter 2008 Earnings Release Conference Call Webcast
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2014)... (PRWEB) November 22, 2014 Respiratory ... simulate the proper management of life-like respiratory ailments ... lung devices . Grand Rapids-based, Michigan Instruments Inc. ... donate two of the respiratory simulation units to ... each. Grand Valley and Muskegon Community College are ...
(Date:11/21/2014)... The science of light and how ... more than 200 primary students in a traveling program ... of Otago Physics Department and funded by an ... of the university’s OSA/SPIE Student Chapter visited six primary ... children from small, rural schools hands-on lessons in optics ...
(Date:11/21/2014)... The November 2014 issue of BioTechniques ... access journal featuring the following articles:, , ... photoresponsiveness in the retina , DNA from ... using chromogenic substrates in zebrafish , Re-use ... electrophoresis , Nuclear LC3-positive puncta in stressed ...
(Date:11/21/2014)... Nov. 20, 2014 Polaris Group announced ... in its Phase 1 trial of ADI-PEG 20 ... treatment of malignant pleural mesothelioma (MPM) and non-squamous ... clinical trials on ADI-PEG 20, both as monotherapy ... treatment of several other indications, including breast cancer, ...
Breaking Biology Technology:Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 3Optics and photonics outreach programs share science, spark fascination with light 2Optics and photonics outreach programs share science, spark fascination with light 3BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3Polaris Group Announces Treatment of First Patient in Phase 1 Study of ADI-PEG 20 plus Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma And Non-Squamous Non-Small Cell Lung Carcinoma 2
... LOUIS, Dec. 8 A new initiative announced,today aims ... States,largest river system, the Mississippi River. Monsanto is partnering ... farmers to,help reduce runoff from the Mississippi River into ... The Nature Conservancy, the Iowa Soybean Association ...
... Iceland, Dec. 8 deCODE genetics,(Nasdaq: ... international consortium of,scientists from deCODE and major European ... in the human genome (SNP) that is associated ... 2 diabetes (T2D). deCODE,will employ its CLIA-registered genotyping ...
... 8 LifeNet Health, a leading allograft bio-implant company, ... Tendon, both offering new options for ligament reconstruction. ... new bio-medical implants offer sports medicine physicians another alternative ... Tendon can be used in the reconstruction of either ...
Cached Biology Technology:New Initiative Focuses on Water Quality Improvement in the Mississippi River Basin and Gulf of Mexico 2New Initiative Focuses on Water Quality Improvement in the Mississippi River Basin and Gulf of Mexico 3New Initiative Focuses on Water Quality Improvement in the Mississippi River Basin and Gulf of Mexico 4New Initiative Focuses on Water Quality Improvement in the Mississippi River Basin and Gulf of Mexico 5New Initiative Focuses on Water Quality Improvement in the Mississippi River Basin and Gulf of Mexico 6New Initiative Focuses on Water Quality Improvement in the Mississippi River Basin and Gulf of Mexico 7deCODE to Integrate New Genetic Risk Factor for Type 2 Diabetes Into Its deCODEme(TM) Personal Genome Scan Service 2deCODE to Integrate New Genetic Risk Factor for Type 2 Diabetes Into Its deCODEme(TM) Personal Genome Scan Service 3deCODE to Integrate New Genetic Risk Factor for Type 2 Diabetes Into Its deCODEme(TM) Personal Genome Scan Service 4LifeNet Health Introduces New Sports Medicine Bio-Implants 2
(Date:11/6/2014)... occur because of metastasis, yet progress in preventing ... , "It,s been particularly challenging to design drugs ... fellow in systems biology at Harvard Medical School. ... after they,ve already metastasized." , Gujral and colleagues ... help researchers better understand how metastasis begins. Their ...
(Date:11/6/2014)... Insilico Medicine, Inc, a Baltimore-based bioinformatics company focused ... announced a research collaboration with the international leader ... (OTC: CSBR). , "There are many companies utilizing ... Oncology,s TumorGraft technology is unique in a way ... generating vast amounts of valuable data. Our bioinformatic ...
(Date:11/5/2014)... – Kelly Redmond has dedicated his career to ... to a general audience. , As deputy director ... Center at Nevada,s Desert Research Institute, Redmond has ... management, application and dissemination of climate data to ... Fall Meeting in San Francisco on December 15-19, ...
Breaking Biology News(10 mins):Migration negation 2Migration negation 3Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2Nevada climatologist to be honored at AGU Fall Meeting for lifetime of public outreach 2
... The University of Manchester have made a surprising finding ... have big implications for research into human healing and ... salamanders have remarkable regenerative capacities, in contrast to mammals, ... tail a new one will regenerate within a week. ...
... Fujian and Shenzhen, China- An international research consortium, led ... completed the first genome sequence of the diamondback moth ... crops. This work provides wider insights into insect adaptation ... sustainable pest management. The latest study was published online ...
... release is available in French and German ... Royal Veterinary College London. Scientists have been able to ... the backbone of early tetrapods, the earliest four-legged animals. High-energy ... to reconstruct the backbones of the 360 million year old ...
Cached Biology News:The secrets of a tadpole's tail and the implications for human healing 2The secrets of a tadpole's tail and the implications for human healing 3The genome of diamondback moth provides new clues for sustainable pest management 2The genome of diamondback moth provides new clues for sustainable pest management 3Scientists reassemble the backbone of life with a particle acceleratorynchrotron X-rays 2Scientists reassemble the backbone of life with a particle acceleratorynchrotron X-rays 3
JAB1 Immunogen: Synthetic peptide, conjugated to KLH, corresponding to residues S(201) E Y Q T I P L N K I E D F G V(216) of human JAB1. The sequence is identical in mouse and rat. Storage: -...
Blank Calibration Particles, 3.0-3.4 mu m 5 ml...
Alexa Fluor 647 anti-mouse IL-12 (Interleukin-12) / IL-23 (Interleukin-23) p40 25 ug...
MAb to Transferrin Dry Ice: No Preservative: NaN3 Availability When Not in Inventory: 14-21 Business Days...
Biology Products: