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Transgenomic Announces Discovery of a Novel Technique Which Enhances Analytic Sensitivity of Standard Sanger Sequencing to 1%
Date:3/29/2011

Sequencing protocol, we have shown we can identify mutations in samples with a mutant to wild-type ratio of 1:100.  We have also shown that BLOCker-Sequencing can discriminate different viral strains which co-elute using DHPLC.  The studies we have performed to date prove that BLOCker-Sequencing is a pivotal methodology for enhancing the mutation detection capabilities of Sanger Sequencing to levels equal to or better than commercially available allele-specific, pyrosequencing and next generation sequencing methods."

Craig Tuttle, Chief Executive Officer and President of Transgenomic commented, "BLOCker-Sequencing is a very exciting discovery.   Our studies have shown that BLOCker-Sequencing will provide a key enhancement to standard Sanger Sequencing.  It extends the utility of using Sanger Sequencing to easily and sensitively measure somatic mutations in cancer similar to how it is used in other areas of diagnostic medicine to measure germ line mutations.  In addition, BLOCker-Sequencing can be combined with our COLD-PCR technologies to provide ultra-sensitive DNA mutation detection allowing us to look for DNA mutations in a patient's blood sample rather than requiring a tumor sample.  Offering a BLOCker-Sequencing and COLD-PCR kit will extend the ability of labs to employ our combined technology for ultra-sensitive mutation detection using equipment and techniques they already have and are widely accepted by regulatory agencies worldwide as the gold standard for mutation detection.  We believe BLOCker-Sequencing coupled with COLD-PCR could revolutionize mutation detection assay technology."

A provisional patent for this new discovery has been filed in the United States.

About Transgenomic, Inc.

Transgenomic, Inc. (www.transgenomic.com) is a global biotechnology company specializing in high sensitivity genetic variation and mutation analysis, pr
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SOURCE Transgenomic, Inc.
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