Navigation Links
Transgene's Therapeutic Vaccine TG4010 Shows Promising Preliminary Phase IIb Data in Advanced Non-Small Cell Lung Cancer
Date:1/10/2008

STRASBOURG, France, January 10 /PRNewswire-FirstCall/ -- Transgene (Euronext Paris: FR0005175080) announces promising preliminary data from the Phase IIb trial evaluating its therapeutic vaccine TG4010 (MVA-MUC1-IL2) as an adjunct to first line chemotherapy in patients with advanced non-small cell lung cancer (NSCLC).

This on-going trial is a randomized, open label and controlled study designed to assess the efficacy of TG4010 in combination with cisplatin and gemcitabine compared to the chemotherapy regimen alone. The trial completed the enrolment of 148 patients at the end of May 2007 and was conducted in 27 centres located in France, Poland, Germany, and Hungary. The patients had NSCLC expressing MUC1, either stage IIIB with effusion or stage IV, and had not received prior systemic treatment for their advanced disease. Half of the patients received the combination regimen (TG 4010 vaccine plus chemotherapy) and the other half of the patients received chemotherapy alone.

The trial confirmed the favourable safety profile of TG4010 when associated to chemotherapy: most adverse events observed so far were considered related to chemotherapy as well as to the underlying disease. Hematological toxicity was equivalent in both treatment groups. Most frequent adverse events related to TG4010 were injection site reactions and asthenia, which are classical vaccine associated reactions.

Based on the local evaluations performed at investigation centres, results so far are showing a positive trend in favour of the combination of TG4010 with the chemotherapy. These results nevertheless remain subject to a centralised review process that is presently on-going.

"We report today encouraging trends on the preliminary results of our Phase IIb trial with TG4010 in non-small cell lung cancer" said Philippe Archinard, Chief Executive Officer of Transgene. "We expect to present data during the second quarter of this year and final data by the fourth qua
'/>"/>

SOURCE Transgene S.A.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. MedImmune Broadens Focus of Venture Capital Fund to Include New Therapeutic Areas
2. Mersana Therapeutics Appoints C. Boyd Clarke Chairman of the Board of Directors
3. Nektar Therapeutics President and CEO Howard W. Robin to Present At JPMorgan 26th Annual Healthcare Conference
4. Cell Therapeutics, Inc. (CTI) Hosts Conference Call to Discuss Update on Zevalin(R) Acquisition, CMS Reimbursement, and PIX301 Timeline
5. MultiCell Technologies To Increase Focus on Therapeutic Candidates
6. Sirnaomics Received Multiple Government Fundings For Its Multi-Targeted siRNA Therapeutics Programs
7. Co-Inventor of Amgens Aranesp(R) Technology Directs Worldwide Patent Strategy for Diffusion Pharmaceuticals First-in-Class Oxygen Enhancing Therapeutics
8. Pearl Therapeutics, Inc. Expands Its Senior Management Team With Top Talent in Clinical Development and Regulatory Affairs
9. Human Genome Sciences and Aegera Therapeutics Announce Licensing and Collaboration Agreement on Novel Anti-Cancer Drugs
10. House and Senate Pass Medicare Legislation to Freeze 2008 Reimbursement for Therapeutic Radiopharmaceuticals at 2007 Levels
11. Lonza Withdraws Majority of Claims in Patent Lawsuit Against Northwest Biotherapeutics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... ... June 30, 2015 , ... ... take part in the first half of “Integrative Biotechnology,” an applied biotechnology course ... in summer 2014, this course combines students from both universities and is taught ...
(Date:6/30/2015)... , June 30, 2015  Today, Americord Registry, one of ... Andrew Horne , a partner at Kirkland & Ellis ... Logo - http://photos.prnewswire.com/prnh/20150630/226958LOGO   "We ... Advisory Board," says Martin Smithmyer , CEO of Americord. ... legal career that will assist Americord,s growth and vision." ...
(Date:6/30/2015)... ... 2015 , ... Matrix Marketing Group, LLC , a leading provider of ... head up its account management department as vice president of client services. Amanda ... account management and delivery expertise to the growing Matrix Marketing Group team in Denver, ...
(Date:6/30/2015)... ... June 30, 2015 , ... Southern Illinois ... the position of vice president of instruction at Chippewa Valley Technical College (CVTC) ... appreciated the opportunity to lead SIUE during the past three years,” Furst-Bowe said. ...
Breaking Biology Technology:Rivier University and Beijing City University Academic and Cultural Exchanges Begin 2Americord Registry Announces Andrew Horne as Advisory Board Member 2Matrix Marketing Group Expands Client Services Team 2SIUE’s Furst-Bowe Accepts VP of Instruction at CVTC 2SIUE’s Furst-Bowe Accepts VP of Instruction at CVTC 3
... BETHESDA, Md., Nov. 10 Spherix Incorporated,(Nasdaq: SPEX ... its,application to transfer the listing of its common stock ... The common stock is expected to,commence trading on the ... Nasdaq Capital Market is one of three market tier ...
... Conference Call Today at 4:30 p.m. Eastern Time -, ... MDVN ) today reported on its corporate progress and ... "The third quarter represented another quarter of significant,achievement and ... partnering,agreement with Pfizer for Dimebon. This collaboration not only ...
... Rise, Net Loss Narrows Compared to Prior Year; Operating Loss ... ... Inc.,(Nasdaq: ENDO ), an innovative medical device company focused on the,development ... tumor ablation, today reported,higher revenue, a 26 percent decline in operating loss, ...
Cached Biology Technology:Spherix Transfers Stock Listing to Nasdaq Capital Market 2Medivation Reports Third Quarter 2008 Financial Results and Provides Corporate Update 2Medivation Reports Third Quarter 2008 Financial Results and Provides Corporate Update 3Medivation Reports Third Quarter 2008 Financial Results and Provides Corporate Update 4Medivation Reports Third Quarter 2008 Financial Results and Provides Corporate Update 5Medivation Reports Third Quarter 2008 Financial Results and Provides Corporate Update 6Medivation Reports Third Quarter 2008 Financial Results and Provides Corporate Update 7Medivation Reports Third Quarter 2008 Financial Results and Provides Corporate Update 8Endocare Reports Financial Results for Third Quarter 2008 2Endocare Reports Financial Results for Third Quarter 2008 3Endocare Reports Financial Results for Third Quarter 2008 4Endocare Reports Financial Results for Third Quarter 2008 5Endocare Reports Financial Results for Third Quarter 2008 6Endocare Reports Financial Results for Third Quarter 2008 7Endocare Reports Financial Results for Third Quarter 2008 8Endocare Reports Financial Results for Third Quarter 2008 9Endocare Reports Financial Results for Third Quarter 2008 10Endocare Reports Financial Results for Third Quarter 2008 11
(Date:6/17/2015)... , June 17, 2015  Crossmatch™, a ... announced that its U.are.U ® 4500 fingerprint ... Eateries, Inc., a San ... chain, to increase security, improve accountability and reduce ... enable instant, non-repudiable identity confirmation for employee sign ...
(Date:6/16/2015)... , June 16, 2015 Fingerprint ... previously communicated that it will amount to at least 340 ... Due to the rapid increase in market growth and orders ... previously communicated guidance that revenue for 2015 will exceed 1,500 ... amount to approximately 2,200 MSEK. Due to receipt ...
(Date:6/12/2015)... 2015  Securus Technologies, a leading provider of ... safety, investigation, corrections and monitoring, announced the United ... capture, analyze and identify participants of a video ... This system can: , Identify ... subsequent sign-on process is actually the person participating ...
Breaking Biology News(10 mins):Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 2Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 3Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 2Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 3Securus Announces Patent Issued for Authorized Presence Verification During Video Visitation 2
... New studies released today underscore the potential impact ... of aging, and learning. The research focused on the ... presented at Neuroscience 2013, the annual meeting of the ... emerging news about brain science and health. The ...
... believed that microorganisms that produce methane swim toward the hydrogen ... too hard to prove in the lab. Montana State ... verify it for the first time, said Matthew Fields, an ... a new paper describing the find. In the process, ...
... tyrosine kinases are a large family of cell-surface ... signals, including insulin, growth factors such as epidermal ... and molecules involved in neuronal guidance. Ligand binding ... leading to recruitment of enzymes and adapter proteins ...
Cached Biology News:Research reveals roles for exercise and diet in aging, depression 2Montana State team overcomes challenges, proves that microbes swim to hydrogen gas 2
... is a new product number, ... product number. If showing no ... the old Sigma-Aldrich number (C7671) ... assistance. Mfr Desig: Corning ...
ABgene® supplies a 94kDa ultra-pure recombinant thermostable DNA polymerase obtained by high level expression of the Taq DNA polymerase gene in E. coli....
Rabbit Anti-Mouse Ym1 Polyclonal Antibody,...
ABgene® supplies a 94kDa ultra-pure recombinant thermostable DNA polymerase obtained by high level expression of the Taq DNA polymerase gene in E. coli....
Biology Products: