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Transave Issued Key Composition of Matter Patent for ARIKACE™
Date:5/24/2010

at enable penetration of the biofilm.  ARIKACE is administered once daily using a customized Investigational eFlow® Nebulizer System (PARI Pharma GmbH), a novel, highly efficient and portable aerosol delivery system enabling more effective distribution in the lungs.  

Positive results were announced in October 2009 from pooled results of two Phase 2 clinical trials in the treatment of CF patients with Pseudomonas lung infections.  The company also previously announced positive Phase 2 results in September 2009 in the treatment of non-CF bronchiectasis patients who have Pseudomonas lung infections.  

ARIKACE has been granted orphan drug status in the United States by the FDA, and has received an orphan drug designation in Europe by the European Medicines Agency for the treatment of Pseudomonas infections in patients with CF.  ARIKACE has also been granted orphan drug status by the FDA for the treatment of bronchiectasis in patients with Pseudomonas or other susceptible pathogens.  

About the Investigational eFlow® Nebulizer System and PARI Pharma

ARIKACE is delivered by an Investigational eFlow® Nebulizer System developed by PARI Pharma and optimized specifically for ARIKACE. The Investigational eFlow Nebulizer System uses eFlow Technology to enable highly efficient aerosolization of medication including liposomal formulations via a vibrating, perforated membrane that includes thousands of laser drilled holes. Compared to other nebulization technologies, eFlow Technology produces aerosols with a very high density of active drug, a precisely defined droplet size, and a high proportion of respirable droplets deli
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SOURCE Transave, Inc.
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