Navigation Links
Toxin detection as close as an inkjet printer

If that office inkjet printer has become just another fixture, it's time to take a fresh look at it. Similar technology may soon be used to develop paper-based biosensors that can detect certain harmful toxins that can cause food poisoning or be used as bioterrorism agents.

In a paper published in the July issue of Analytical Chemistry, John Brennan and his research team at McMaster University, working with the Sentinel Bioactive Paper Network, describe a method for printing a toxin-detecting biosensor on paper using a FujiFilm Dimatix Materials Printer.

The researchers demonstrated the concept on the detection of acetylcholinesterase (AChE) inhibitors such as paraoxon and aflatoxin B1 on paper using a "lateral flow" sensing approach similar to that used in a home pregnancy test strip.

The process involves formulating an ink like the one found in computer printer cartridges but with special additives to make the ink biocompatible. An ink comprised of biocompatible silica nanoparticles is first deposited on paper, followed by a second ink containing the enzyme, and the resulting bio-ink forms a thin film of enzyme that is entrapped in the silica on paper. When the enzyme is exposed to a toxin, reporter molecules in the ink change colour in a manner that is dependent on the concentration of the toxin in the sample.

This simple and cost-effective method of adhering biochemical reagents to paper is expected to bring the concept of bioactive paper a significant step closer to commercialization. The goal for bioactive paper is to provide a rapid, portable, disposable and inexpensive way of detecting harmful substances, including toxins, pathogens and viruses, without the need for sophisticated instrumentation. The research showed that the printed enzyme retains full activity for at least two months when stored properly, suggesting that such sensor strips should have a good shelf life.

Portable bio-sensing papers are expected to be extremely useful in monitoring environmental and food-based toxins, as well as in remote settings in less industrialized countries where simple bioassays are essential for the first stages of detecting disease.

Applications for bioactive paper also include clinical applications in neuroscience, drug assessment, and pharmaceutical development.


Contact: Gene Nakonechny
905-525-9140 x26781
McMaster University

Related biology technology :

1. Spectral announces presentations at the 29TH International Symposium on Intensive Care and Emergency Medicine focusing on the role of endotoxin
2. PharmAthene Presents Data for SparVax(TM) and Valortim(R), a Novel Vaccine and Anti-Toxin for the Prevention and Treatment of Anthrax Infection at the 7th Annual ASM Biodefense Meeting
3. Medarex And PharmAthene Announce New Therapeutic Data for Anthrax Anti-Toxin, Valortim(R)
4. Spectral announces continuing support for the combination of EAA(TM) and anti-endotoxin therapeutics
5. Spectrals EAA(TM) to be used in Phase III study for a sepsis anti-endotoxin therapy
6. New Online Learning Tool Fills the Knowledge Gap on Botulinum Toxin Type B for Cervical Dystonia
7. New designer toxins kill Bt-resistant insect pests
8. Abbott HIV Test Demonstrates Earlier Disease Detection
9. febit First to Offer Newly Published Mouse Genome on a Chip for DNA/RNA Detection and Enrichment
10. EyeIC Receives FDA 510(k) Clearance for MatchedFlicker(TM) Retinal Aid Detection Technology
11. BD and Fujirebio Diagnostics Sign Worldwide Agreement to Develop Biomarker Assays to Improve Cancer Detection and Management
Post Your Comments:
Related Image:
Toxin detection as close as an inkjet printer
(Date:10/12/2015)... and BRUSSELS , Oct. 12, ... Brussels: UCB) today presented additional findings from an exploratory sub-study ... The findings were presented today in an oral plenary session ... 2015 Annual Meeting in Seattle . ... --> The small exploratory sub-study data showed that, ...
(Date:10/12/2015)... 12, 2015 cell surface marker detection ... 2022, according to a new report by Grand View Research, ... in incidence of oncology diseases and other cell-associated disorders. ... to reach USD 6.49 billion by 2022, according to a ... demand can be attributed to rise in incidence of oncology ...
(Date:10/12/2015)... -- offers user-friendly, multi ... experience --> offers ... enriched online experience --> ... print version for enriched online experience ... medical information products and services, announced today that it ...
(Date:10/11/2015)... ... October 11, 2015 , ... Intelligent Implant Systems, LLC ... and multiple surgeries have been completed with this new posterior thoracolumbar spinal fusion ... Spine Center of the Carolinas. The Revolution™ Spinal System pioneers a new ...
Breaking Biology Technology:
(Date:9/29/2015)... -- News facts: , ... , Minimized design shrinks PC footprint , ... embedded Fujitsu PalmSecure authentication enable enterprises to realize benefits ... that good things come in small packages, with the ... desktop and mobile portfolio. Featuring workplace design that favors ...
(Date:9/28/2015)... YORK , Sept. 28, 2015 /PRNewswire/ ... announced today that its expedited traveler service ... innovative platform transforms travel, bringing a frictionless ... its members. "CLEAR offers our ... enhances customer service," said Jim Smith ...
(Date:9/28/2015)... , September 28, 2015 ... expected to reach USD 12.03 billion by 2020, growing ... Technological advancements such as Backside Illumination (BSI) technique to ... over the forecast period.      (Logo: ... of the chip to reduce loss and, thus, reduce ...
Breaking Biology News(10 mins):