Navigation Links
Topokine Announces Dosing of First Subject in a Phase I Clinical Trial of XAF5 Gel for Local Reduction of Subcutaneous Fat
Date:12/5/2012

Newton, MA (PRWEB) December 05, 2012

Topokine Therapeutics has announced that the first subject has been dosed in a repeat-dose, healthy volunteer study of XAF5 Gel, a skin cream for local reduction of excess subcutaneous fat (lipohypertrophy). The study is assessing the safety and tolerability of repeat doses of XAF5 Gel at three concentrations. The study is also quantifying the effects of XAF5 on subcutaneous adipose tissue.

“We are excited to enter clinical development with the first non-invasive, local drug therapy to reduce lipohypertrophy,” said Topokine’s Chief Scientific Officer, Michael Singer, MD, PhD. “We hope to provide a convenient and effective alternative to surgery and injections.”

XAF5 is an adipomodulatory compound that inhibits adipocytes by engaging a cell-surface receptor, resulting in down-regulation of key adipocyte transcription factors. XAF5 reduces adipose tissue in vivo without inflammation or necrosis.

“Topokine’s preclinical data are promising,” said Jeffrey S. Dover, MD, FRCPC, a nationally recognized dermatologist and member of the Company’s Scientific Board of Advisors. “A skin cream that reduces subcutaneous fat would be an attractive proposition for patients and physicians alike.”

The company expects to report top-line results in the first half of 2013.

About Topokine and XAF5 Gel
Topokine Therapeutics is a clinical-stage biotechnology company developing therapies for dermatology and medical aesthetics. The company's lead program, XAF5 Gel, is a skin cream being developed for local reduction of excess subcutaneous fat. XAF5 is an adipomodulatory compound that inhibits adipocytes by engaging a cell-surface receptor, resulting in down-regulation of key adipocyte transcription factors. XAF5 reduces adipose tissue in vivo without inflammation or necrosis.

Forward-Looking Statements
This press release contains forward-looking statements regarding the development of XAF5. These statements are based on Topokine’s current beliefs and expectations, but actual results may differ.

Read the full story at http://www.prweb.com/releases/2012/12/prweb10203404.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related biology technology :

1. Biocartis Announces Commercial Launch of a New Biomarker Analysis Platform
2. Chemical Publishing Company Announces its Niche Catalog in the Water Technology and Water Treatment Space
3. Japan Bioinformatics Announces Study on Leading Mapping Tools for DNA Mutation Discovery
4. The Scientist Proudly Announces the Top 10 Innovations of 2012
5. Bayer CropScience Announces LibertyLink LinkUp Offer Increased for 2013 Season
6. IntelliCell BioSciences Announces Research Agreement with the New Jersey Center for Biomaterials at Rutgers-The State University of New Jersey
7. Genomic Health Announces Presentation of Six Studies at the 2012 CTRC-AACR San Antonio Breast Cancer Symposium
8. Smith & Nephew Announces Agreement To Acquire Assets Of Healthpoint Biotherapeutics
9. Ampio Pharmaceuticals, Inc. (AMPE) announces appointment of Josh Disbrow as Chief Operating Officer effective December 15, 2012
10. Amarantus BioSciences Announces Positive Data for MANF in Delivery Diffusion Animal Model of Parkinsons Disease
11. BioRestorative Therapies Announces Launch of New Website
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2017)... WI (PRWEB) , ... June 26, 2017 , ... Third ... in role of Sales Director, focused on leading new business development and ensuring quality ... years of experience in the food ingredient industry in technical, marketing and sales roles. ...
(Date:6/23/2017)... , ... June 23, 2017 , ... Biova, LLC., the ... has joined Biova’s Board of Directors. Dr. Henig will bring a wealth of scientific ... has served as the Chief Technical and Scientific Officer of four major global companies ...
(Date:6/23/2017)... ... June 23, 2017 , ... ... a redesigned, easier-to-navigate website for all six of their healthcare job boards. ... dentists, pharmacists, physical and occupational therapists, and biotechnicians, DocCafe.com and the MedJobCafe.com ...
(Date:6/22/2017)... ... June 21, 2017 , ... RMC ... Carolina, and engages Timothy Reinhardt to manage the new site. , Tim has ... Inc, with his most recent role as the Director of Manufacturing and Supplier ...
Breaking Biology Technology:
(Date:4/24/2017)... , April 24, 2017 ... and partner with  Identity Strategy Partners, LLP (IdSP) ... "With or without President Trump,s March 6, 2017 ... Terrorist Entry , refugee vetting can be instilled with ... resettlement. (Right now, all refugee applications are suspended ...
(Date:4/13/2017)... 2017 UBM,s Advanced Design and Manufacturing event ... emerging and evolving technology through its 3D Printing and ... alongside the expo portion of the event and feature ... focused on trending topics within 3D printing and smart ... event will take place June 13-15, 2017 at the Jacob ...
(Date:4/11/2017)... , April 11, 2017 No ... but researchers at the New York University Tandon ... of Engineering have found that partial similarities between ... systems used in mobile phones and other electronic ... The vulnerability lies in the fact ...
Breaking Biology News(10 mins):