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Tolerx Initiates Phase 1 Clinical Trial of TRX518, a First-in-Class anti-GITR Antibody for the Treatment of Cancer
Date:12/14/2010

or the treatment of other cancers, building on the broad potential of GITR as a fundamental mechanism involved in cancer as well as preclinical proof of concept studies of TRX518 in multiple models of established and metastatic cancer.

"Starting this first-in-human study with TRX518 in an oncology indication is an important milestone for Tolerx. TRX518 has a novel mechanism of action and has the potential to enhance an anti-tumor immune response, regardless of tumor type, and this has tremendous potential for a broad variety of malignancies," said Louis Vaickus, MD, Chief Medical Officer at Tolerx.  "TRX518 works through GITR (glucocorticoid-induced tumor necrosis factor receptor), a molecule that has been recognized by the National Cancer Institute and other experts as one of the most promising targets in cancer immunotherapy."

About TRX518

TRX518 is a targeted T cell immunotherapy that activates GITR (glucocorticoid-induced tumor necrosis factor receptor) found on multiple types of T cells and other immune cells. Activated GITR plays a role in directing the anti-tumor immune response via activating tumor-antigen-specific T effector cells, as well as abrogating the suppression induced by inappropriately activated T regulatory cells.  In preclinical studies, TRX518 achieved its targeted effect without compromising normal immune function, and preclinical models suggest TRX518 may have a reduced risk of causing serious inflammatory side effects that can result from cytokine release.  TRX518 is designed to have activating and sustaining effects on T cells for enhancing the immune system's responses against cancer cells, including responses that may occur with TRX518 alone, as well as complementary responses in combination with other cancer therapies including vaccines.  

About Tolerx

Tolerx, Inc., a world leader in the understanding of T cell function, is developing novel therapies intended to treat
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SOURCE Tolerx, Inc.
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