Navigation Links
Tips from the Journals of the American Society for Microbiology
Date:9/22/2007

For the first time researchers have developed an animal model for oral poliovirus infection. They report their findings in the August 2007 issue of the Journal of Virology.

Poliovirus causes acute disease in the central nervous system in humans often resulting in paralysis. Due to its reemerging presence in developing countries researchers are reexamining the viruses ability to spread among humans through oral ingestion and develop new preventative therapies accordingly.

Due to the human digestive tracts low sensitivity to the poliovirus, no previous rodent model tracking oral infection has been developed. In the study mice carrying the human poliovirus receptor gene and lacking the interferon receptor gene (IFNAR) were sensitive to an oral challenge of the poliovirus. Nine days following the challenge the mice had died and the virus was detected in their small intestines and digestive tracts. Mice expressing the interferon receptor gene were found to be much less sensitive to virus.

These results suggest that IFNAR plays an important role in determining permissivity in the alimentary tract as well as the generation of virus-specific immune responses to poliovirus via the oral route, say the researchers. Thus, hPVR-Tg/IfnarKO are considered to be the first oral infection model for poliovirus.

(S. Ohka, H. Igarashi, N. Nagata, M. Sakai, S. Koike, T. Nochi, H. Kiyono, A. Nomoto. 2007. Establishment of a poliovirus oral infection system in human poliovirus receptor-expressing transgenic mice that are deficient in alpha/beta interferon receptor. Journal of Virology, 81. 15: 7902-7912).


'/>"/>

Contact: Carrie Patterson
cpatterson@asmusa.org
American Society for Microbiology
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. A disgusting video: U.S. companies sell out Americans
2. Northwestern Mutual, American Family make Computerworlds best IT workplaces
3. Brazilian bio-industry should impress American investors
4. CIO Leadership Series: Byrne Chapman, American Family Insurance
5. Metavante fires 180 North American workers
6. 300 millionth American no cause for eco-alarm
7. American Idol spurs music software
8. Healthcare software addresses "90 million" misclassified Americans
9. Technology and the "American" dream
10. Peters: Innovation the only edge that remains for American business
11. We are American No sex, please
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... January 15, 2014 A study has been ... the Formula 1 track could help to tackle the problem ... (MAT), Stowhealth (a GP surgery based in Stowmarket) and academics ... Simplyhealth. Telemetry technology, which is inspired by equipment ...
(Date:1/15/2014)... Rochester, NY (PRWEB) January 15, 2014 The ... cause a major disease. One of these latent viruses is ... is rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic ... the theory, a study found that RA patients have high ...
(Date:1/15/2014)... Freeslate, Inc ., the leading ... Lupin Limited, one of India’s top five pharmaceutical companies, ... System for high throughput solid form screening. ... a wide range of quality, affordable generic and branded ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Date: Friday, April ... Location: Warrington Country Club, 1360 Almshouse Road, Warrington, Pa. ... nonprofit organization solely dedicated to finding a cure for hepatitis ... worldwide, will host its annual Crystal Ball on Friday, April ...
Breaking Biology Technology:Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2
... and OSAKA, Japan, May 18, 2011 Cellectis ... genome customization specialist, has appointed Wako Pure Chemical ... Company,s broad portfolio of research products and services, ... Chemical Industries is a leading distributor of research ...
... SAN JOSE, Calif., May 18, 2011 Oclaro, Inc. ... optical communications and laser solutions, today announced that its ... by Pantec Biosolutions, the leading provider of epidermal medical ... Laser Epidermal System) platform. This cutting-edge new laser platform ...
... May 17, 2011 New data presented today ... moderate to severe chronic prostatitis/chronic pelvic pain syndrome ... meeting of the American Urological Association, RAPAFLO(R) also ... of life. Chronic prostatitis/chronic pelvic pain ...
Cached Biology Technology:Cellectis bioresearch Appoints Wako as Exclusive Distributor of its Genome Customization Solutions in Japan 2Pantec Biosolutions Selects Oclaro Laser Diode Bars for Transdermal Drug Delivery and Tissue Ablation Systems 2Pantec Biosolutions Selects Oclaro Laser Diode Bars for Transdermal Drug Delivery and Tissue Ablation Systems 3Pantec Biosolutions Selects Oclaro Laser Diode Bars for Transdermal Drug Delivery and Tissue Ablation Systems 4Watson Pharmaceuticals Announces New Research Showing RAPAFLO(R) (silodosin) Improves Outcomes for Chronic Prostatitis/Chronic Pelvic Pain Syndrome 2Watson Pharmaceuticals Announces New Research Showing RAPAFLO(R) (silodosin) Improves Outcomes for Chronic Prostatitis/Chronic Pelvic Pain Syndrome 3Watson Pharmaceuticals Announces New Research Showing RAPAFLO(R) (silodosin) Improves Outcomes for Chronic Prostatitis/Chronic Pelvic Pain Syndrome 4Watson Pharmaceuticals Announces New Research Showing RAPAFLO(R) (silodosin) Improves Outcomes for Chronic Prostatitis/Chronic Pelvic Pain Syndrome 5Watson Pharmaceuticals Announces New Research Showing RAPAFLO(R) (silodosin) Improves Outcomes for Chronic Prostatitis/Chronic Pelvic Pain Syndrome 6
(Date:4/17/2014)... ALBUQUERQUE, N.M. A credit-card-sized anthrax detection cartridge developed ... small business makes testing safer, easier, faster and cheaper. ... causes anthrax, is commonly found in soils all over ... illness in both humans and animals. The bacteria can ... to B. anthracis may occur through skin ...
(Date:4/17/2014)... A Kansas State University engineer has developed a ... detects improvised explosive devices. The same technique could ... the Steven M. and Kay L. Theede chair ... nuclear engineering, and his research team have created ... or in car trunks. The distance detection method ...
(Date:4/17/2014)... Clemson professor Rajendra Singh Thursday as a "Champion ... expand solar deployment in the residential, commercial and ... Professor of Electrical and Computer Engineering and director ... a local hero leading the charge across the ... solar power and driving policy changes at the ...
Breaking Biology News(10 mins):Pocket-sized anthrax detector aids global agriculture 2Pocket-sized anthrax detector aids global agriculture 3Patented research remotely detects nitrogen-rich explosives 2White House honors Clemson professor as 'Champion of Change' for solar deployment 2
... at the recent United Nations meeting emphasized nutrition as ... of State Hillary Clinton said a key focus is ... of Missouri nutrition experts say getting back to basics ... families and communities in many ways. As ...
... to be met is a significant increase in the use ... to grow in the future, because biomass is used in ... and various types of materials. The planning of biomass usage ... gap between what is included in countries, and regions, current ...
... Clemson University researchers recently reported finding a new class ... how cells repair damaged DNA. The finding from Cao,s ... with computational chemist Brian Dominy appeared in the Sept. ... "A new family of deamination repair enzymes in ...
Cached Biology News:Eating balanced meals, farm-fresh produce benefits families, communities, nutrition researchers say 2Better planning required if EU is to meet energy targets 2Clemson University biochemists identify new genetic code repair tool 2
Component of HyperMu™ Insertion Kit...
Request Info...
... x 2 , Maintenance ... /each , Immunizations/Boost injections x5 ... ml) x1 /each , Production bleed ... Final Bleed ~ 100 ml blood (~50 ml ...
... 500 g protein in ... mouse whole cell lysate; Abelson transformed macrophage ... as Western blotting positive control, ... and thawing should be minimized, ...
Biology Products: