Navigation Links
Tiny channel cleanses blood
Date:5/2/2012

Margination, the natural phenomenon where bacteria and leukocytes (white blood cells) move toward the sides of blood vessels, is the inspiration for a novel method for treating sepsis, a systemic and often dangerous inflammatory response to microbial infection in the blood. A team of researchers at the Massachusetts Institute of Technology and the National University of Singapore has designed a branchlike system of microfluidic channels, 20 micrometers (20 millionths of a meter, or about one-fifth the size of a grain of sand) high by 20 micrometers wide, that mimic the marginizing action of vessels on bacteria and inflammatory cellular components (leukocytes and platelets) to separate them from red blood cells.

The microchannel network is etched onto a polymer chip by the same techniques used for manufacturing integrated circuits. As infected whole blood flows through the first part of the microchannel, red cells migrate toward the center while the unwanted cell types flow toward the side walls. Like a biological railway junction, the second part of the microchannel is divided into three branches with red cells taking the middle path and the marginated microbes, leukocytes, and platelets moving into the two outer ones. A second three-branch junction further purifies the red cell fraction, which could then be returned to a patient in a real-life situation.

In their experiment with the prototype device, the researchers demonstrated highly efficient removal of the bacteria Escherichia coli (80 percent) and the yeast Saccharomyces cerevisiae (90 percent) as well as a greater than 80 percent depletion of inflammatory cellular components. The researchers also designed and tested a larger blood cleansing system consisting of six microfluidic channel networks in parallel.

Currently, they are conducting a small-scale animal test to validate the efficacy of the technique in vivo.


'/>"/>

Contact: Catherine Meyers
cmeyers@aip.org
301-209-3088
American Institute of Physics
Source:Eurekalert

Page: 1

Related biology technology :

1. Cellectricon Launches Dynaflow® Resolve System Enabling Novel Ion Channel Assays
2. Valkee and University of Oulu Publish the First Clinical Trial on Bright Light Therapy Channeled via ear Canals in Seasonal Depression
3. Nanowrinkles, nanofolds yield strange hidden channels
4. CalciMedica Initiates Phase I Clinical Trial of First CRAC Channel Inhibitor (CCI) for Psoriasis
5. Safe and Secure TV Channel Expanding Programming and Revenue Agreements for 2011 with Pentagons Military News Channel and other Security Industry Leaders
6. Scientists observe single ions moving through tiny carbon-nanotube channel
7. Case Western Reserve University-led team takes high resolution photo of a K+ channel
8. VizVOCUS's Digital Camera Used by Dr. Mehmet Oz on Discovery Channel Special
9. New Generation Disinfecting Products to be Launched in Direct Sales Channel
10. Science Channel Announces the Debut of Exclusive Look Into Dr. J. Craig Venters Creation of Synthetic Life
11. Gilson, Inc. Selects EDL Consulting's CloudCraze For Cross-Channel Webstore Expansion in Europe
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... October 12, 2017 , ... ... Market with the addition of its newest module, US Hemostats & Sealants. , ... thrombin hemostats, absorbable hemostats, fibrin sealants, synthetic sealants and biologic sealants used in ...
(Date:10/12/2017)... Diego, CA (PRWEB) , ... ... ... (https://www.onramp.bio/ ) has launched Rosalind™, the first-ever genomics analysis platform specifically ... all bioinformatics complexity. Named in honor of pioneering researcher Rosalind Franklin, who ...
(Date:10/11/2017)... ... October 11, 2017 , ... The CRISPR-Cas9 system ... experiments and avoiding the use of exogenous expression plasmids. The simplicity of programming ... systematic gain-of-function studies. , This complement to loss-of-function studies, such as with ...
(Date:10/11/2017)... ... 11, 2017 , ... ComplianceOnline’s Medical Device Summit is back for its 4th ... in San Francisco, CA. The Summit brings together current and former FDA office bearers, ... and government officials from around the world to address key issues in device compliance, ...
Breaking Biology Technology:
(Date:7/20/2017)... , July 20, 2017 Delta (NYSE: DAL ) ... any Delta aircraft at Reagan Washington National Airport (DCA). ... Delta launches biometrics to board ... Delta,s biometric boarding ... Club is now integrated into the boarding process to allow eligible ...
(Date:5/16/2017)... , May 16, 2017  Veratad Technologies, LLC ( ... online age and identity verification solutions, announced today they ... Conference 2017, May 15 thru May 17, 2017, in ... and International Trade Center. Identity impacts ... and in today,s quickly evolving digital world, defining identity ...
(Date:4/18/2017)... April 18, 2017  Socionext Inc., a global expert in SoC-based ... edge server, the M820, which features the company,s hybrid codec technology. ... by Tera Probe, Inc., will be showcased during the upcoming Medtec ... show at the Las Vegas Convention Center ... Click here ...
Breaking Biology News(10 mins):