Navigation Links
Tiny channel cleanses blood
Date:5/2/2012

Margination, the natural phenomenon where bacteria and leukocytes (white blood cells) move toward the sides of blood vessels, is the inspiration for a novel method for treating sepsis, a systemic and often dangerous inflammatory response to microbial infection in the blood. A team of researchers at the Massachusetts Institute of Technology and the National University of Singapore has designed a branchlike system of microfluidic channels, 20 micrometers (20 millionths of a meter, or about one-fifth the size of a grain of sand) high by 20 micrometers wide, that mimic the marginizing action of vessels on bacteria and inflammatory cellular components (leukocytes and platelets) to separate them from red blood cells.

The microchannel network is etched onto a polymer chip by the same techniques used for manufacturing integrated circuits. As infected whole blood flows through the first part of the microchannel, red cells migrate toward the center while the unwanted cell types flow toward the side walls. Like a biological railway junction, the second part of the microchannel is divided into three branches with red cells taking the middle path and the marginated microbes, leukocytes, and platelets moving into the two outer ones. A second three-branch junction further purifies the red cell fraction, which could then be returned to a patient in a real-life situation.

In their experiment with the prototype device, the researchers demonstrated highly efficient removal of the bacteria Escherichia coli (80 percent) and the yeast Saccharomyces cerevisiae (90 percent) as well as a greater than 80 percent depletion of inflammatory cellular components. The researchers also designed and tested a larger blood cleansing system consisting of six microfluidic channel networks in parallel.

Currently, they are conducting a small-scale animal test to validate the efficacy of the technique in vivo.


'/>"/>

Contact: Catherine Meyers
cmeyers@aip.org
301-209-3088
American Institute of Physics
Source:Eurekalert

Page: 1

Related biology technology :

1. Cellectricon Launches Dynaflow® Resolve System Enabling Novel Ion Channel Assays
2. Valkee and University of Oulu Publish the First Clinical Trial on Bright Light Therapy Channeled via ear Canals in Seasonal Depression
3. Nanowrinkles, nanofolds yield strange hidden channels
4. CalciMedica Initiates Phase I Clinical Trial of First CRAC Channel Inhibitor (CCI) for Psoriasis
5. Safe and Secure TV Channel Expanding Programming and Revenue Agreements for 2011 with Pentagons Military News Channel and other Security Industry Leaders
6. Scientists observe single ions moving through tiny carbon-nanotube channel
7. Case Western Reserve University-led team takes high resolution photo of a K+ channel
8. VizVOCUS's Digital Camera Used by Dr. Mehmet Oz on Discovery Channel Special
9. New Generation Disinfecting Products to be Launched in Direct Sales Channel
10. Science Channel Announces the Debut of Exclusive Look Into Dr. J. Craig Venters Creation of Synthetic Life
11. Gilson, Inc. Selects EDL Consulting's CloudCraze For Cross-Channel Webstore Expansion in Europe
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2017)... PA (PRWEB) , ... June 22, 2017 , ... ... and superior results to clients throughout the biopharma and life sciences industries, continue ... the industry is seeing. Tunnell’s Kip Wolf will be speaking on “The State ...
(Date:6/20/2017)... ... 20, 2017 , ... CTNext , Connecticut’s go-to resource ... a Higher Education Entrepreneurship Advisory Committee to implement the recommendations of the master ... representatives from 35 higher education institutions across the state over the past six ...
(Date:6/20/2017)... (PRWEB) , ... June 20, 2017 , ... ... Linda Robbie, PhD, a well-versed leader with extensive assay development and biomarker expertise, ... Cambridge Biomedical is a Boston CRO specializing in bio-analytical assay development and sample ...
(Date:6/19/2017)... ... June 19, 2017 , ... EDETEK, ... reported today that it is launching two new additions of its award-winning cloud-based ... new capabilities at the DIA 2017 Annual Meeting in Chicago, IL, June 19-22, ...
Breaking Biology Technology:
(Date:4/11/2017)... Florida , April 11, 2017 ... a security technology company, announces the appointment of independent Directors ... Bendheim to its Board of Directors, furthering the company,s ... ... of NXT-ID, we look forward to their guidance and benefiting ...
(Date:4/5/2017)... April 5, 2017  The Allen Institute for Cell ... Explorer: a one-of-a-kind portal and dynamic digital window into ... data, the first application of deep learning to create ... cell lines and a growing suite of powerful tools. ... these and future publicly available resources created and shared ...
(Date:4/5/2017)... -- KEY FINDINGS The global market for ... of 25.76% during the forecast period of 2017-2025. The ... the growth of the stem cell market. ... INSIGHTS The global stem cell market is segmented on ... stem cell market of the product is segmented into ...
Breaking Biology News(10 mins):